Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Carlos E. Vaca"'
Publikováno v:
Risk Analysis. 19:309-320
Publikováno v:
Risk Analysis. 19:309-320
A mechanistic model and associated procedures are proposed for cancer risk assessment of genotoxic chemicals. As previously shown for ionizing radiation, a linear multiplicative model was found to be compatible with published experimental data for et
Publikováno v:
Carcinogenesis. 17:1035-1040
The effects of dietary fatty acid composition on the endogenous formation of DNA adducts of malonaldehyde (MA), the major product of lipid peroxidation, were investigated in humans. A group of 59 healthy individuals of both sexes and different ages w
Autor:
Ronald Simon, Gary M. Pepper, Anita Soni, Carlos E. Vaca, Harry Gruenspan, Piotr M. Wyrwinski, Teodulo Pina, Nelky E. Ramirez
Publikováno v:
The American Journal of Medicine. 98:266-271
Purpose In patients with septic shock, to (1) determine the incidence of adrenal insufficiency (AI), (2) observe the effects of glucocorticoid therapy on outcome in those with impaired adrenal function, and (3) investigate a possible correlation betw
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 313:269-276
32 P-Postlabelling was applied to study the distribution of adducts in white blood cells of foundry workers exposed to polycylic aromatic hydrocarbons. The distribution of the adducts among 63 workers followed an apparently trimodal pattern, which co
Publikováno v:
Carcinogenesis. 14:705-708
The stability of the adducts of malonaldehyde (MA) to N-terminal valine in hemoglobin (Hb) and to guanine at N1,N2 in liver DNA was determined in vivo. Mice were injected with radiolabeled or unlabeled MA and the decay of the levels of Hb and DNA add
Publikováno v:
Carcinogenesis. 12:1097-1102
Hemoglobin (Hb) adduct determination by the N-alkyl Edman method was used for in vivo dosimetry of endogenously formed malonaldehyde (MA) and ethene in mice fed diets with different fatty acid composition and induced for lipid peroxidation with carbo
Publikováno v:
Chemico-biological interactions. 108(3)
Acetaldehyde (AA) and methylglyoxal (MG) are reactive, ubiquitous aldehydes, present in the environment and endogenously formed in animals and humans. They have both been shown to readily form DNA adducts under simulated physiological conditions. We
Autor:
Jia Long Fang, Carlos E. Vaca
Publikováno v:
Carcinogenesis. 18(4)
The effect of alcohol drinking on the formation of DNA adducts of acetaldehyde, the primary oxidative metabolite of ethanol, was investigated in humans. DNA was isolated from granulocytes and lymphocytes from 24 alcoholic patients and 12 control subj
Autor:
Jia-Long Fang, Carlos E. Vaca
Publikováno v:
Carcinogenesis. 16(9)
A 32P-postlabelling assay was developed for the analysis of adducts arising from the reaction of 2'-deoxyguanosine-3'-monophosphate with acetaldehyde, the primary oxidative metabolite of ethanol. The 32P-postlabelling reaction was optimized by testin