Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Carlos E. Milla"'
Autor:
Minyoung Kevin Kim, Qingquan Chen, Arne Echterhof, Nina Pennetzdorfer, Robert C. McBride, Niaz Banaei, Elizabeth B. Burgener, Carlos E. Milla, Paul L. Bollyky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Bacteriophage (phage) therapy is a promising therapeutic modality for multidrug-resistant bacterial infections, but its application is mainly limited to personalized therapy due to the narrow host range of individual phages. While phage cock
Externí odkaz:
https://doaj.org/article/1a0e592dc25140378c37bdb18745f44a
Autor:
Medeea C. Popescu, Naomi L. Haddock, Elizabeth B. Burgener, Laura S. Rojas-Hernandez, Gernot Kaber, Aviv Hargil, Paul L. Bollyky, Carlos E. Milla
Publikováno v:
Viruses, Vol 16, Iss 1, p 165 (2024)
Background: The inovirus Pf4 is a lysogenic bacteriophage of Pseudomonas aeruginosa (Pa). People with Cystic Fibrosis (pwCF) experience chronic airway infection with Pa and a significant proportion have high numbers of Pf4 in their airway secretions.
Externí odkaz:
https://doaj.org/article/9fe7d46604d04d53acc440207a002477
Autor:
Nam Soo Joo, Hyung-Ju Cho, Meagan Shinbashi, Jae Young Choi, Carlos E. Milla, John F. Engelhardt, Jeffrey J. Wine
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Mucus clearance, a primary innate defense mechanism of airways, is defective in patients with cystic fibrosis (CF) and CF animals. In previous work, the combination of a low dose of the cholinergic agonist, carbachol with forskolin or a β a
Externí odkaz:
https://doaj.org/article/91154804265f4012ae9f1330a2cf12f1
Autor:
Michael J. Kratochvil, Gernot Kaber, Sally Demirdjian, Pamela C. Cai, Elizabeth B. Burgener, Nadine Nagy, Graham L. Barlow, Medeea Popescu, Mark R. Nicolls, Michael G. Ozawa, Donald P. Regula, Ana E. Pacheco-Navarro, Samuel Yang, Vinicio A. de Jesus Perez, Harry Karmouty-Quintana, Andrew M. Peters, Bihong Zhao, Maximilian L. Buja, Pamela Y. Johnson, Robert B. Vernon, Thomas N. Wight, Stanford COVID-19 Biobank Study Group, Carlos E. Milla, Angela J. Rogers, Andrew J. Spakowitz, Sarah C. Heilshorn, Paul L. Bollyky
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to
Externí odkaz:
https://doaj.org/article/5333021197714d0f86602625ced4f91f
Autor:
Joelle I. Rosser, Nadine Nagy, Riya Goel, Gernot Kaber, Sally Demirdjian, Jamie Saxena, Jennifer B. Bollyky, Adam R. Frymoyer, Ana E. Pacheco-Navarro, Elizabeth B. Burgener, Jayakumar Rajadas, Zhe Wang, Olga Arbach, Colleen E. Dunn, Anissa Kalinowski, Carlos E. Milla, Paul L. Bollyky
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
BACKGROUND Hyaluronan (HA), an extracellular matrix glycosaminoglycan, has been implicated in the pathophysiology of COVID-19 infection, pulmonary hypertension, pulmonary fibrosis, and other diseases, but is not targeted by any approved drugs. We ask
Externí odkaz:
https://doaj.org/article/f748f673d08f429f9f1becca4580831e
Autor:
Patrick R. Secor, Elizabeth B. Burgener, M. Kinnersley, Laura K. Jennings, Valery Roman-Cruz, Medeea Popescu, Jonas D. Van Belleghem, Naomi Haddock, Conner Copeland, Lia A. Michaels, Christiaan R. de Vries, Qingquan Chen, Julie Pourtois, Travis J. Wheeler, Carlos E. Milla, Paul L. Bollyky
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa, a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and other temperate phages have evolved complex, mutualistic relationships
Externí odkaz:
https://doaj.org/article/0fbbcd58934c4e5bade6db1d83a8f046
Autor:
Eszter K. Vladar, Koshi Kunimoto, Laura S. Rojas-Hernandez, Jacquelyn M. Spano, Zachary M. Sellers, Nam Soo Joo, Riley A. Cooney, Jeffrey D. Axelrod, Carlos E. Milla
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L771-L782
Our findings show that low-dose, short-term topical or systemic γ-secretase inhibitor treatment may lead to restoration of multiciliated cells without toxicity and potentially improve epithelial function in a wide range of chronic lung diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e22e0a5a956ef85cf164f502bf26d711
https://doi.org/10.1152/ajplung.00382.2022
https://doi.org/10.1152/ajplung.00382.2022
Laterality Defects in Primary Ciliary Dyskinesia: Relationship to Ultrastructural Defect or Genotype
Autor:
Andrew T. Barber, Adam J. Shapiro, Stephanie D. Davis, Thomas W. Ferkol, Jeffrey J. Atkinson, Scott D. Sagel, Sharon D. Dell, Kenneth N. Olivier, Carlos E. Milla, Margaret Rosenfeld, Lang Li, Feng-Chang Lin, Kelli M. Sullivan, Nicole A. Capps, Maimoona A. Zariwala, Michael R. Knowles, Margaret W. Leigh
Publikováno v:
Annals of the American Thoracic Society. 20:397-405
The association between organ laterality abnormalities and ciliary ultrastructural defect or genotype in primary ciliary dyskinesia is poorly understood.To determine if there is an association between presence/type of laterality abnormality and cilia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98b324634872e405094b9acc2bedfe0
https://doi.org/10.1513/annalsats.202206-487oc
https://doi.org/10.1513/annalsats.202206-487oc
Autor:
Medeea C Popescu, Naomi L Haddock, Elizabeth B Burgener, Laura S Rojas-Hernandez, Gernot Kaber, Aviv Hargil, Paul L Bollyky, Carlos E Milla
Basal airway epithelial cells are a multipotent stem cell population which gives rise to several airway cell types. Basal cells are known to be critical to airway epithelium homeostasis and repair, and altered basal cell phenotypes have been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a40d62a3c05d829cd8ddf50168125c6
https://doi.org/10.1101/2022.09.27.509771
https://doi.org/10.1101/2022.09.27.509771
Autor:
Michael J. Kratochvil, Gernot Kaber, Sally Demirdjian, Pamela C. Cai, Elizabeth B. Burgener, Nadine Nagy, Graham L. Barlow, Medeea Popescu, Mark R. Nicolls, Michael G. Ozawa, Donald P. Regula, Ana E. Pacheco-Navarro, Samuel Yang, Vinicio A. de Jesus Perez, Harry Karmouty-Quintana, Andrew M. Peters, Bihong Zhao, Maximilian L. Buja, Pamela Y. Johnson, Robert B. Vernon, Thomas N. Wight, Carlos E. Milla, Angela J. Rogers, Andrew J. Spakowitz, Sarah C. Heilshorn, Paul L. Bollyky
Publikováno v:
JCI Insight
Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e6ccb5ccb8e900bf17f1f8ac5cc42b
https://pubmed.ncbi.nlm.nih.gov/35411348
https://pubmed.ncbi.nlm.nih.gov/35411348