Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Carlos E. Crespo‐Hernández"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102171- (2024)
Nucleoside-modified messenger RNA (mRNA) technologies necessarily incorporate N1-methylpseudouridine into the mRNA molecules to prevent the over-stimulation of cytoplasmic RNA sensors. Despite this modification, mRNA concentrations remain mostly dete
Externí odkaz:
https://doaj.org/article/3631b7beeaa441aeabaab1ee68433e4b
Autor:
Luis A. Ortiz-Rodríguez, Christian Reichardt, Sean J. Hoehn, Steffen Jockusch, Carlos E. Crespo-Hernández
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The mechanisms of formation of the (6-4) photoproducts in DNA damage by sunlight is still debated. Here the authors show, by optical spectroscopies and computations, the details of the formation of a (6-4) photoadduct via the thietane intermediate in
Externí odkaz:
https://doaj.org/article/343811f9b7a74c7babd79d0230667245
Publikováno v:
Molecules, Vol 27, Iss 4, p 1184 (2022)
Cyanuric acid is a triazine derivative that has been identified from reactions performed under prebiotic conditions and has been proposed as a prospective precursor of ancestral RNA. For cyanuric acid to have played a key role during the prebiotic er
Externí odkaz:
https://doaj.org/article/fa1480d52f6d44f0b4dad2bd46508ad9
Autor:
Sebastian Mai, Marvin Pollum, Lara Martínez-Fernández, Nicholas Dunn, Philipp Marquetand, Inés Corral, Carlos E. Crespo-Hernández, Leticia González
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Sulfur-substituted nucleobases are promising photo- and chemotherapeutic drugs. Here, the authors unravel the electronic and structural aspects that lead to the ultrafast population of triplet states in these molecules, providing an explanation for t
Externí odkaz:
https://doaj.org/article/c339189a8d4e464ca93ecdb74b57c3f1
Publikováno v:
Molecules, Vol 25, Iss 3, p 584 (2020)
Sulfur-substituted DNA and RNA nucleobase derivatives (a.k.a., thiobases) are an important family of biomolecules. They are used as prodrugs and as chemotherapeutic agents in medical settings, and as photocrosslinker molecules in structural-biology a
Externí odkaz:
https://doaj.org/article/fe8fb0c3764a4456956d2d5732fed6df
Autor:
Carlos E. Crespo-Hernández
Publikováno v:
Molecules, Vol 22, Iss 12, p 2203 (2017)
Understanding the fundamental interaction between electromagnetic radiation and matter is essential for a large number of phenomena, with significance to civilization.[...]
Externí odkaz:
https://doaj.org/article/cdfcbf65ada34c78b153a0600d881ebe
Publikováno v:
Molecules, Vol 22, Iss 3, p 379 (2017)
6-Thioguanine, an immunosuppressant and anticancer prodrug, has been shown to induce DNA damage and cell death following exposure to UVA radiation. Its metabolite, 6-thioguanosine, plays a major role in the prodrug’s overall photoreactivity. Howeve
Externí odkaz:
https://doaj.org/article/8f4d7f7973cf47b6b2ca9937cb8d0bf4
Autor:
Sarah E. Krul, Gustavo J. Costa, Sean J. Hoehn, Danillo Valverde, Leonardo M. F. Oliveira, Antonio Carlos Borin, Carlos E. Crespo‐Hernández
Publikováno v:
Photochemistry and Photobiology. 99:693-705
The guanine derivative, 5-aza-7-deazaguanine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612d4e2eb928ac60104ddd87426dd637
https://doi.org/10.1111/php.13688
https://doi.org/10.1111/php.13688
Autor:
Naishka E. Caldero-Rodríguez, Luis A. Ortiz-Rodríguez, Andres A. Gonzalez, Carlos E. Crespo-Hernández
Publikováno v:
Physical Chemistry Chemical Physics. 24:4204-4211
Ultraviolet radiation (UVR) from the sun is essential for the prebiotic syntheses of nucleotides, but it can also induce photolesions such as the cyclobutane pyrimidine dimers (CPDs) to RNA or DNA oligonucleotide in prebiotic Earth. 2,6-Diaminopurine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c489197914e62559f84a1ed7e5946c
https://doi.org/10.1039/d1cp05269a
https://doi.org/10.1039/d1cp05269a
Sunlight is the primary source of energy to promote change on Earth. In this context, ultraviolet radiation can be thought as a catalyst of chemical change to refine chemical feedstocks and facilitate their transformations into the building blocks of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf3848ce588c54977f9098f121ccdf3
https://doi.org/10.31219/osf.io/63bvg
https://doi.org/10.31219/osf.io/63bvg
