Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Carlos E Orozco-Barrios"'
Autor:
David Reyes-Corona, Nallely Vázquez-Hernández, Lourdes Escobedo, Carlos E Orozco-Barrios, Jose Ayala-Davila, Mario Gil Moreno, Miriam E Amaro-Lara, Yazmin M Flores-Martinez, Armando J Espadas-Alvarez, Manuel A Fernandez-Parrilla, Juan A Gonzalez-Barrios, M E Gutierrez-Castillo, Ignacio González-Burgos, Daniel Martinez-Fong
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188239 (2017)
The structural effect of neurturin (NRTN) on the nigrostriatal dopaminergic system in animals remains unknown, although NRTN has been shown to be effective in Parkinson's disease animal models. Herein, we aimed to demonstrate that NRTN overexpression
Externí odkaz:
https://doaj.org/article/4fadb68ef0c849c2811bd905f3dc57f3
Autor:
Juan U. Mascotte-Cruz, Arturo Vera, Lorenzo Leija, Francisco E. Lopez-Salas, Michael Gradzielski, Joachim Koetz, Bismark Gatica-García, C. P. Rodríguez-Oviedo, Irais E. Valenzuela-Arzeta, Lourdes Escobedo, David Reyes-Corona, ME. Gutierrez-Castillo, Minerva Maldonado-Berny, Armando J. Espadas-Alvarez, Carlos E. Orozco-Barrios, Daniel Martinez-Fong
Publikováno v:
Discover Nano, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Neurotensin-polyplex nanoparticles provide efficient gene transfection of nigral dopaminergic neurons when intracerebrally injected in preclinical trials of Parkinson’s disease because they do not cross the blood–brain barrier (BBB). The
Externí odkaz:
https://doaj.org/article/50dc39fbb81043508cc35ba8c82dfc8a
Autor:
Irais E. Valenzuela-Arzeta, Luis O. Soto-Rojas, Yazmin M. Flores-Martinez, Karen M. Delgado-Minjares, Bismark Gatica-Garcia, Juan U. Mascotte-Cruz, Porfirio Nava, Omar Emiliano Aparicio-Trejo, David Reyes-Corona, Irma A. Martínez-Dávila, M. E. Gutierrez-Castillo, Armando J. Espadas-Alvarez, Carlos E. Orozco-Barrios, Daniel Martinez-Fong
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4628 (2023)
Whether neuroinflammation leads to dopaminergic nigrostriatal system neurodegeneration is controversial. We addressed this issue by inducing acute neuroinflammation in the substantia nigra (SN) with a single local administration (5 µg/2 µL saline s
Externí odkaz:
https://doaj.org/article/f6d9298c367a44d4b2fcd57e39ed6e6e
Autor:
Ximena Freyermuth-Trujillo, Julia J. Segura-Uribe, Hermelinda Salgado-Ceballos, Carlos E. Orozco-Barrios, Angélica Coyoy-Salgado
Publikováno v:
Cells, Vol 11, Iss 17, p 2692 (2022)
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that generate beneficial outcomes and have no side effects are urgently needed. SCI may be treatable if intervention is initiated promptly. Therefore, several t
Externí odkaz:
https://doaj.org/article/bf48304983c14040b2f499fbe894626b
Autor:
Daniel Martinez-Fong, Carlos E. Orozco-Barrios, Rasajna Nadella, Rosana Fiorentino-Pérez, Minerva Maldonado-Berny, David Reyes-Corona, Bismark Gatica-Garcia, Francisco E. Lopez-Salas, Moreno Mario Gil, Ubaldo García, Maria L. Escobedo-Sanchez, Maria E. Gutierrez-Castillo, Manuel A. Fernandez-Parrilla
Publikováno v:
Molecular pharmaceutics. 17(12)
Neurotensin (NTS)-polyplex is a multicomponent nonviral vector that enables gene delivery via internalization of the neurotensin type 1 receptor (NTSR1) to dopaminergic neurons and cancer cells. An approach to improving its therapeutic safety is repl
Autor:
Maria Guadalupe Olayo, Vinnitsa Buzoianu-Anguiano, Guillermo J. Cruz, Araceli Diaz-Ruiz, Laura Alvarez-Mejia, Stephanie Sánchez-Torres, Hermelinda Salgado-Ceballos, Camilo Ríos, Cristian González-Ruiz, Rodrigo Mondragón-Lozano, Roberto Olayo, Omar Fabela-Sánchez, Pablo Damián-Matsumura, Juan Morales, Sandra Orozco-Suárez, Axayacatl Morales-Guadarrama, Carlos E. Orozco-Barrios, Angélica Coyoy-Salgado
Publikováno v:
Journal of materials science. Materials in medicine. 31(7)
Traumatic spinal cord injury (TSCI) can cause paralysis and permanent disability. Rehabilitation (RB) is currently the only accepted treatment, although its beneficial effect is limited. The development of biomaterials has provided therapeutic possib
Autor:
Jose Ayala-Davila, Lourdes Escobedo-Sanchez, Guadalupe Soto-Rodriguez, Daniel Martinez-Fong, M. Eugenia Gutierrez-Castillo, Carlos E. Orozco-Barrios, Michael J. Bannon, Armando J. Espadas-Alvarez, David Reyes-Corona, V. Escamilla-Rivera, America Padilla-Viveros, Andrea De Vizcaya-Ruiz
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 13:1363-1375
The human glial-cell derived neurotrophic factor (hGDNF) gene transfer by neurotensin (NTS)-polyplex nanoparticles functionally restores the dopamine nigrostriatal system in experimental Parkinson's disease models. However, high levels of sustained e
Autor:
Sandra Orozco-Suárez, Carlos E. Orozco-Barrios, Christian Guerra-Araiza, Hermelinda Salgado-Ceballos, Juan Manuel Gallardo, Angélica Coyoy-Salgado, Iris A. Feria-Romero, Julia J. Segura-Uribe
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Patients with spinal cord injury (SCI) face devastating health, social, and financial consequences, as well as their families and caregivers. Reducing the levels of reactive oxygen species (ROS) and oxidative stress are essential strategies for SCI t
Autor:
Eduardo Brambila, Jorge Cebada, Constantino Tomas-Sanchez, Maricela Torres-Soto, Carlos E. Orozco-Barrios, Lourdes Millan-PerezPeña, Ana-Karina Aguilar-Peralta, Guadalupe Soto-Rodriguez, Bertha Alicia León-Chávez, Ilhuicamina Daniel Limón, Juan-Antonio Gonzalez-Barrios, Daniel Martinez-Fong, Alejandro Gonzalez-Vazquez, Victor-Manuel Blanco-Alvarez
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
In the cerebral hypoxia-ischemia rat model, the prophylactic administration of zinc can cause either cytotoxicity or preconditioning effect, whereas the therapeutic administration of selenium decreases the ischemic damage. Herein, we aimed to explore
Autor:
Teresa Mejia-Castillo, Patricia Forgez, Yazmin M. Flores-Martinez, Jose Ayala-Davila, Daniel Hernandez-Baltazar, Lenin Pavón, Víctor M. Tellez-Lopez, Hector Rubio, Jesus D. Rembao, Rosa Angélica Castillo-Rodríguez, Daniel Martinez-Fong, Aurora Sánchez-García, Martha L. Arango-Rodríguez, María Eugenia Hernández, Carlos E. Orozco-Barrios
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 10:745-754
Neurotensin (NTS)-polyplex is a gene nanocarrier that has potential nanomedicine-based applications for the treatment of Parkinson's disease and cancers of cells expressing NTS receptor type 1. We assessed the acute inflammatory response to NTS-polyp