Neural Androgen Receptor Deletion Impairs the Temporal Processing of Objects and Hippocampal CA1-Dependent Mechanisms.

Autor: Marie Picot, Jean-Marie Billard, Carlos Dombret, Christelle Albac, Nida Karameh, Stéphanie Daumas, Hélène Hardin-Pouzet, Sakina Mhaouty-Kodja

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148328 (2016)

We studied the role of testosterone, mediated by the androgen receptor (AR), in modulating temporal order memory for visual objects. For this purpose, we used male mice lacking AR specifically in the nervous system. Control and mutant males were gona

Externí odkaz: https://doaj.org/article/bc26a2aabf214b059cf623b2ce71d509

Systems genetic analysis of osteoblast-lineage cells.

Autor: Gina Calabrese, Brian J Bennett, Luz Orozco, Hyun M Kang, Eleazar Eskin, Carlos Dombret, Olivier De Backer, Aldons J Lusis, Charles R Farber

Publikováno v: PLoS Genetics, Vol 8, Iss 12, p e1003150 (2012)

The osteoblast-lineage consists of cells at various stages of maturation that are essential for skeletal development, growth, and maintenance. Over the past decade, many of the signaling cascades that regulate this lineage have been elucidated; howev

Externí odkaz: https://doaj.org/article/ef00689e5bc74a559b69dc28c528c1a2

Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations

Autor: Christoph J. Mache, Bodo B. Beck, Malte P. Bartram, Janine Altmüller, Thomas Benzing, L. K. Duin, Mathieu J.M. Bertrand, Markus M. Rinschen, Sung Sen Yang, Sicco A. Scherjon, Kamel Laghmani, Olivier De Backer, Tom J. de Koning, Björn Reusch, Holger Thiele, Shih-Hua Lin, Sylvie Demaretz, Hannsjörg W. Seyberth, Karl P. Schlingmann, Elena Levtchenko, Albert Timmer, Günter Klaus, Heike Göbel, Gökhan Yigit, Andrea Wenzel, Martin Kömhoff, Carlos Dombret, Elie Seaayfan, Helga Vitzthum, Klasien Bergmann, Martin Konrad, Dario Priem, Peter Nürnberg

Publikováno v: Laghmani, K, Beck, B B, Yang, S S, Seaayfan, E, Wenzel, A, Reusch, B, Vitzthum, H, Priem, D, Demaretz, S, Bergmann, K, Duin, L K, Gobel, H, Mache, C, Thiele, H, Bartram, M P, Dombret, C, Altmuller, J, Nurnberg, P, Benzing, T, Levtchenko, E, Seyberth, H W, Klaus, G, Yigit, G, Lin, S H, Timmer, A, De Koning, T J, Scherjon, S A, Schlingmann, K P, Bertrand, M J M, Rinschen, M M, De Backer, O, Konrad, M & Komhoff, M 2016, ' Polyhydramnios, transient antenatal bartter's syndrome, and MAGED2 mutations ', New England Journal of Medicine, vol. 374, no. 19, pp. 1853-1863 . https://doi.org/10.1056/NEJMoa1507629
New England Journal of Medicine, 374(19), 1853-1863. MASSACHUSETTS MEDICAL SOC

Background Three pregnancies with male offspring in one family were complicated by severe polyhydramnios and prematurity. One fetus died; the other two had transient massive salt-wasting and polyuria reminiscent of antenatal Bartter's syndrome. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684551e17fe107b0bbd21eea4a0badf0
https://doi.org/10.1056/NEJMoa1507629

Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus

Autor: Olivier Schakman, Carlos Dombret, Hélène Hardin-Pouzet, Tuan Nguyen, Olivier De Backer, Mathieu J.M. Bertrand, Jacques L. Michaud

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2012, 21 (21), pp.4703-4717. ⟨10.1093/hmg/dds310⟩
Human Molecular Genetics, 2012, 21 (21), pp.4703-4717. ⟨10.1093/hmg/dds310⟩

International audience; MAGED1, NECDIN and MAGEL2 are members of the MAGE gene family. The latter two of these genes have been involved in PraderWilli syndrome (PWS), which includes hyperphagia, repetitive and compulsive behaviors, and cognitive impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b20a9038dd866f0e7be6b9cd2373286
https://hal.archives-ouvertes.fr/hal-01542831

Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice.

Autor: Dombret, Carlos¹, Naulé, Lydie¹, Trouillet, Anne-Charlotte¹, Parmentier, Caroline¹, Hardin-Pouzet, Hélène¹, Mhaouty-Kodja, Sakina¹ sakina.mhaouty-kodja@upmc.fr

Publikováno v: Scientific Reports. 4/10/2020, Vol. 10 Issue 1, p1-14. 14p.