Výsledky vyhledávání - "Carlos D. Martins"

Data from HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging

Autor: Gabriela Kramer-Marek, Graham Smith, Wim J.G. Oyen, Kevin J. Harrington, Louis Allott, Daniela M. Ciobota, Rhodri Smith, Thomas A. Burley, Chiara Da Pieve, Carlos D. Martins

Purpose: Recent studies have highlighted a role of HER3 in HER2-driven cancers (e.g., breast cancer), implicating the upregulation of the receptor in resistance to HER-targeted therapies and Hsp90 inhibitors (e.g., AUY922). Therefore, we have develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::319e1decfc82bee5d18d838c987f213f
https://doi.org/10.1158/1078-0432.c.6525815.v1

Zobrazit plný text záznamu

Supporting Materials from HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging

Autor: Gabriela Kramer-Marek, Graham Smith, Wim J.G. Oyen, Kevin J. Harrington, Louis Allott, Daniela M. Ciobota, Rhodri Smith, Thomas A. Burley, Chiara Da Pieve, Carlos D. Martins

Materials and Methods Fig. S1. Time course of AUY922 treatment in BT-474 and MCF-7 cells. Fig. S2. Effects of AUY922 and PPP treatment in low and high HER2-expressing breast cancer cell lines. Fig. S3. Effect of HRG stimulation in AUY922 and PPP trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bbae65be7548e00f5e6357352e0f7a2
https://doi.org/10.1158/1078-0432.22464815.v1

Zobrazit plný text záznamu

MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer

Autor: Joanne Edwards, Somaieh Hedayat, Claudio Murgia, Owen J. Sansom, Gabriela Kramer-Marek, Luciano Cascione, Elisa Fontana, Pierluigi Gasparini, Jens C. Hahne, Carlo M. Croce, Matteo Fassan, Carlos D. Martins, Andrea Lampis, Paul G. Horgan, Georgios Vlachogiannis, L. Terracciano, Chiara Braconi, Nicola Valeri

Publikováno v: Cell Death and Differentiation

Junctional adhesion molecules (JAMs) play a critical role in cell permeability, polarity and migration. JAM-A, a key protein of the JAM family, is altered in a number of conditions including cancer; however, consequences of JAM-A dysregulation on car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f505631a7b9ad2c414dd03cc099b6aab
http://europepmc.org/articles/PMC8481293

Zobrazit plný text záznamu

18F-meta-fluorobenzylguanidine (18F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models

Autor: Thomas C. Wilson, Gabriela Kramer-Marek, Véronique Gouverneur, Stephen Turnock, Louis Chesler, David R Turton, Carlos D. Martins, Graham Smith

Publikováno v: Scientific Reports

Targeted radiotherapy with 131I-mIBG, a substrate of the human norepinephrine transporter (NET-1), shows promising responses in heavily pre-treated neuroblastoma (NB) patients. Combinatorial approaches that enhance 131I-mIBG tumour uptake are of subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a2ab6ba248530a79f3354c5804e298
https://ora.ox.ac.uk/objects/uuid:15779b9f-d389-4f4a-9835-8e95a054eaa9

Zobrazit plný text záznamu

Affibody-Based PET Imaging to Guide EGFR-Targeted Cancer Therapy in Head and Neck Squamous Cell Cancer Models

Autor: Louis Allott, Thomas A Burley, Gabriela Kramer-Marek, Daniela M. Ciobota, Chiara Da Pieve, Graham Smith, Kevin J. Harrington, Carlos D. Martins, Wim J.G. Oyen

Publikováno v: Journal of Nuclear Medicine

In head and neck squamous cell cancer, the human epidermal growth factor receptor 1 (EGFR) is the dominant signaling molecule among all members of the family. So far, cetuximab is the only approved anti-EGFR monoclonal antibody used for the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac636b7224c59e4fa38aff178a3a19ad
https://doi.org/10.2967/jnumed.118.216069

Zobrazit plný text záznamu

Radioimmunotherapy for delivery of cytotoxic radioisotopes: current status and challenges

Autor: Gabriela Kramer-Marek, Carlos D. Martins, Wim J.G. Oyen

Publikováno v: Expert opinion on drug delivery. 15(2)

Introduction: Radioimmunotherapy (RIT) with monoclonal antibodies and their fragments labelled with radionuclides emitting alpha-particles, beta-particles or Auger electrons have been used for many years in the development of anticancer strategies. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d60cdea35f7559ea749ca86b012499
https://pubmed.ncbi.nlm.nih.gov/28893110

Zobrazit plný text záznamu

Efficient [(18)F]AlF Radiolabeling of ZHER3:8698 Affibody Molecule for Imaging of HER3 Positive Tumors

Autor: Carlos D. Martins, Graham Smith, Gabriela Kramer-Marek, Andrew Vardon, Louis Allott, Daniela M. Ciobota, Chiara Da Pieve

Publikováno v: Bioconjugate chemistry. 27(8)

The human epidermal growth factor receptor 3 (HER3) is overexpressed in several cancers, being linked to a more resistant phenotype and hence leading to poor patient prognosis. Imaging HER3 is challenging owing to the modest receptor number (50000 re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c344f151f95c86005cacca8aa9a9f2
https://pubmed.ncbi.nlm.nih.gov/27357023

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání