Výsledky vyhledávání - "Carlos D. Gamarra-Luques"

Akademický článek

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors

Autor: Lei Zhang, Maria B. Hapon, Alicia A. Goyeneche, Rekha Srinivasan, Carlos D. Gamarra-Luques, Eduardo A. Callegari, Donis D. Drappeau, Erin J. Terpstra, Bo Pan, Jennifer R. Knapp, Jeremy Chien, Xuejun Wang, Kathleen M. Eyster, Carlos M. Telleria

Publikováno v: Molecular Oncology, Vol 10, Iss 7, Pp 1099-1117 (2016)

The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of different genetic backgrounds

Externí odkaz: https://doaj.org/article/dd087c8833bd49a0b6248a9faae346ec

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Facile Synthesis of a Phototoxic Monofunctionalized Tetraarylporphyrin as Scaffold for Porphyrin-Quinone Conjugates

Autor: Grigoriy Sereda, Carlos D. Gamarra-Luques, Carlos M. Telleria, Ramkumar Moorthy

Publikováno v: Synthetic Communications. 43:182-190

A new carboxy-monofunctionalized tertraarylporphyrin has been tested for cytotoxicity toward OV2008 human ovarian cancer cells. This compound acutely inhibits growth of ovarian cancer cells upon exposure to ambient light while suppresses long-term cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a54dde70851250bcb245db0e992ddb7
https://doi.org/10.1080/00397911.2011.594546

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Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors

Autor: Carlos D. Gamarra-Luques, Carlos M. Telleria, Jeremy Chien, Erin J Terpstra, Bo Pan, Alicia A. Goyeneche, Jennifer R. Knapp, Eduardo Callegari, Kathleen M. Eyster, Rekha Srinivasan, Donis D. Drappeau, Lei Zhang, Xuejun Wang, María Belén Hapon

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af27e9aec7d6844f0c4b11af4cf2d0c
Wiley Online Library

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Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin- induced cytotoxicity

Autor: María Belén Hapon, Carlos M. Telleria, Carlos D. Gamarra-Luques, Alicia A. Goyeneche

Publikováno v: Journal of Ovarian Research
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

BACKGROUND: Antiprogestin compounds have been shown to be effective in blocking the growth of ovarian cancer cells of different genetic backgrounds. Herein we studied the anti-ovarian cancer effect of a series of antiprogestins sharing the chemical b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401be1dd288dd2ad4b892c22f5a274c9
https://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-7-45

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Synergistic Lethality of Mifepristone and LY294002 in Ovarian Cancer Cells

Autor: Stacy L. Wempe, Carlos D. Gamarra-Luques, Carlos M. Telleria

Publikováno v: Cancer Growth and Metastasis, Vol 6 (2013)
Cancer Growth and Metastasis, Vol 2013, Iss 6, Pp 1-13 (2013)
Cancer Growth and Metastasis

We have previously shown that the antiprogestin and antiglucocorticoid mifepristone inhibits the growth of ovarian cancer cells. In this work, we hypothesized that cellular stress caused by mifepristone is limited to cytostasis and that cell killing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72343bd04e9d8d9f017d6849bb5e667
https://doaj.org/article/87a95fef64f349f3a347bb1c4d182959

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Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy

Autor: María Belén Hapon, Carlos D. Gamarra-Luques, Alicia A. Goyeneche, Carlos M. Telleria

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BMC Cancer, Vol 12, Iss 1, p 200 (2012)
BMC Cancer

Background: Advanced ovarian cancer is treated with cytoreductive surgery and combination platinum- and taxane-based chemotherapy. Although most patients have acute clinical response to this strategy, the disease ultimately recurs. In this work we qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f661875d4b0dc877b1a1c88514823f4
https://doi.org/10.1186/1471-2407-12-200

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Abstract A23: Induction of the unfolded protein response in ovarian cancer cells exposed to cytostatic concentrations of antiprogestin/antiglucocorticoid mifepristone

Autor: Carlos D. Gamarra-Luques, Kathleen M. Eyster, María Belén Hapon, Alicia A. Goyeneche, Carlos M. Telleria, Eduardo Callegari

Publikováno v: Clinical Cancer Research. 19:A23-A23

Ovarian cancer is rare; yet, it is the deadliest gynecologic malignancy with a 5-year survival rate that has only improved 9% in the past 30 years and a dismal overall survival rate that has remained stagnant for over 50 years. Although most patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef9e2b1f95b3a95cae2b3641e051e977
https://doi.org/10.1158/1078-0432.ovca13-a23

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Abstract 2098: Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells

Autor: Carlos M. Telleria, Stacy L. Wempe, Carlos D. Gamarra-Luques

Publikováno v: Cancer Research. 73:2098-2098

We have previously shown that the antiprogestin/antiglucocorticoid mifepristone inhibits the growth of ovarian cancer cells. In this work, we hypothesized that cellular stress caused by mifepristone is limited to cytostasis and that cell killing is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a441145d9fe49c04c33a747b7c655268
https://doi.org/10.1158/1538-7445.am2013-2098

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Abstract 363: Antiprogestin mifepristone improves the efficacy of the combination therapy cisplatin/paclitaxel in human ovarian carcinoma cells in vitro

Autor: Carlos D. Gamarra-Luques, Carlos M. Telleria, María Belén Hapon, Alicia A. Goyeneche

Publikováno v: Cancer Research. 71:363-363

Ovarian Cancer (OCa) is the second most common gynecologic malignancy and the leading cause of gynecologic cancer-related deaths in the developed world. The main reason for its poor prognosis is that the majority of cases are diagnosed at advanced st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd9440360c28349932b97dc1b5279e62
https://doi.org/10.1158/1538-7445.am2011-363

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