Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Carlos Costas-Insua"'
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Autor:
Carlos Costas-Insua, Alba Hermoso-López, Estefanía Moreno, Carlos Montero-Fernández, Alicia Álvaro-Blázquez, Irene B Maroto, Andrea Sánchez-Ruiz, Rebeca Diez-Alarcia, Cristina Blázquez, Paula Morales, Enric I Canela, Vicent Casadó, Leyre Urigüen, Gertrudis Perea, Luigi Bellocchio, Ignacio Rodríguez-Crespo, Manuel Guzmán
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 755-783 (2024)
Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that
Externí odkaz:
https://doaj.org/article/5c7b69f9446144719e20ce1f4a631547
Autor:
Irene B. Maroto, Carlos Costas-Insua, Coralie Berthoux, Estefanía Moreno, Andrea Ruiz-Calvo, Carlos Montero-Fernández, Andrea Macías-Camero, Ricardo Martín, Nuria García-Font, José Sánchez-Prieto, Giovanni Marsicano, Luigi Bellocchio, Enric I. Canela, Vicent Casadó, Ismael Galve-Roperh, Ángel Núñez, David Fernández de Sevilla, Ignacio Rodríguez-Crespo, Pablo E. Castillo, Manuel Guzmán
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The type-1 cannabinoid receptor (CB1R) is widely expressed in excitatory and inhibitory nerve terminals, and by suppressing neurotransmitter release, its activation modulates neural circuits and brain function. While the interaction of CB1R
Externí odkaz:
https://doaj.org/article/de2f897065d34da0933b217db4f53983
Autor:
Alba Hermoso-López, Carlos Costas-Insua, Carlos Montero-Fernández, Estefanía Moreno, Alicia Álvaro-Blázquez, David Martín-Gutiérrez, Irene B. Maroto-Martínez, Rebeca Diez-Alarcia, Leyre Urigüen, Vicent Casadó, Ignacio Rodríguez-Crespo, Manuel Guzmán
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S848- (2023)
Externí odkaz:
https://doaj.org/article/b668f7103ab240249d28d67435c8975d
The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice
Autor:
Marc Espina, Nadia Di Franco, Martina Brañas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzmán, Silvia Ginés
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106225- (2023)
Increasing evidence indicates that a key factor in neurodegenerative diseases is the activation of the unfolded protein response (UPR) caused by an accumulation of misfolded proteins in the endoplasmic reticulum (ER stress). Particularly, in Huntingt
Externí odkaz:
https://doaj.org/article/ede8d1825f004ae789741daebb76f3ed
Autor:
Marta Gómez-Almería, Sonia Burgaz, Carlos Costas-Insua, Carmen Rodríguez-Cueto, Irene Santos-García, Ignacio Rodríguez-Crespo, Concepción García, Manuel Guzmán, Eva de Lago, Javier Fernández-Ruiz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12533 (2021)
In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS
Externí odkaz:
https://doaj.org/article/0596c9acd46f48c0a93625dc3145c5b7
Autor:
Irene Maroto, Carlos Costas-Insua, Coralie Berthoux, Estefania Moreno, Andrea Ruiz-Calvo, Carlos Montero-Fernández, Andrea Macías-Camero, Ricardo Martín, Nuria García-Font, José Sánchez-Prieto, Giovanni Marsicano, Luigi Bellocchio, Enric Canela, Vicent Casado, Ismael Galve-Roperh, David Fernandez de Sevilla, Ignacio Rodríguez-Crespo, Pablo Castillo, Manuel Guzmán
The type-1 cannabinoid receptor (CB1R) is widely expressed in both excitatory and inhibitory nerve terminals, and its activation, by suppressing neurotransmitter release, modulates neural circuits and brain function. While the interaction of CB1R wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbe7ee7b82e20f34c072bc9d419c1894
https://doi.org/10.21203/rs.3.rs-2128033/v1
https://doi.org/10.21203/rs.3.rs-2128033/v1
Autor:
Carlos Costas-Insua, Marta Seijo-Vila, Cristina Blázquez, Sandra Blasco-Benito, Francisco Javier Rodríguez-Baena, Giovanni Marsicano, Eduardo Pérez-Gómez, Cristina Sánchez, Berta Sánchez-Laorden, Manuel Guzmán
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2439
Melanoma is one of the deadliest forms of cancer. Most melanoma deaths are caused by distant metastases in several organs, especially the brain, the so-called melanoma brain metastases (MBMs). However, the precise mechanisms that sustain the growth o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e4eac2cbce34e80ed3974f44dd536f
https://doi.org/10.3390/cancers15092439
https://doi.org/10.3390/cancers15092439
Autor:
Carlos Costas-Insua, Manuel Guzmán
Publikováno v:
E-Prints Complutense. Archivo Institucional de la UCM
Universidad Europea (UEM)
Universidad Europea (UEM)
High-grade gliomas constitute the most frequent and aggressive form of primarybrain cancer in adults. These tumors express cannabinoid CB1and CB2receptors, aswell as other elements of the endocannabinoid system. Accruing preclinical evidencesupports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd6d15daf5e30b6d9522a3e53bbc18d
https://eprints.ucm.es/id/eprint/72624/
https://eprints.ucm.es/id/eprint/72624/
Autor:
Eva de Lago, Carlos Costas-Insua, Concepción García, Javier Fernández-Ruiz, Irene Santos-García, Marta Gómez-Almería, Carmen Rodríguez-Cueto, Ignacio Rodríguez-Crespo, Sonia Burgaz, Manuel Guzmán
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12533, p 12533 (2021)
E-Prints Complutense. Archivo Institucional de la UCM
instname
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12533, p 12533 (2021)
E-Prints Complutense. Archivo Institucional de la UCM
instname
Volume 22
Issue 22
In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bc1bfd855af5e80951c7965f9221ce
https://eprints.ucm.es/id/eprint/71672/
https://eprints.ucm.es/id/eprint/71672/
Autor:
David Martín-Gutiérrez, Ignacio Rodríguez-Crespo, Giovanni Marsicano, Joaquin Botta, Leyre Urigüen, José Sánchez-Prieto, Marc Espina, Rebeca Diez-Alarcia, Irene B. Maroto, Carlos Costas-Insua, Nuria García-Font, Raquel Bajo-Grañeras, Peter J. McCormick, Roser Cortés, Vicent Casadó, Andrea Ruiz-Calvo, Manuel Guzmán, Enric I. Canela, M. Teresa Vilaró, Ismael Galve-Roperh, Estefanía Moreno, Silvia Ginés, Guadalupe Mengod, Luigi Bellocchio, Ricardo Martín
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2021, 41 (38), pp.7924-7941. ⟨10.1523/JNEUROSCI.0821-21.2021⟩
Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Neuroscience, Society for Neuroscience, 2021, 41 (38), pp.7924-7941. ⟨10.1523/JNEUROSCI.0821-21.2021⟩
Addi. Archivo Digital para la Docencia y la Investigación
instname
Digital.CSIC. Repositorio Institucional del CSIC
Dipòsit Digital de la UB
Universidad de Barcelona
Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1 cannabinoid receptor (CB1R). Accruing evidence supports that cannabinoid action relies on context-dependent factors, such as the biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37fb9bb32a834bae66d420b7820be79
http://hdl.handle.net/2445/181159
http://hdl.handle.net/2445/181159