Self-association of MreC as a regulatory signal in bacterial cell wall elongation

Autor: Alexandre Martins, Carlos Contreras-Martel, Manon Janet-Maitre, Mayara M. Miyachiro, Leandro F. Estrozi, Daniel Maragno Trindade, Caíque C. Malospirito, Fernanda Rodrigues-Costa, Lionel Imbert, Viviana Job, Guy Schoehn, Ina Attrée, Andréa Dessen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

MreC is a membrane-associated protein that modulates the activity of the elongasome, a protein complex that controls cell wall formation in rod-shaped bacteria. Here, the authors use electron cryo-microscopy and X-ray crystallography to determine the

Externí odkaz: https://doaj.org/article/bfd9056a555a4b14acc5e2a6e24d19b1

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

Autor: Cécile Morlot, Daniel Straume, Katharina Peters, Olav A. Hegnar, Nolwenn Simon, Anne-Marie Villard, Carlos Contreras-Martel, Francisco Leisico, Eefjan Breukink, Christine Gravier-Pelletier, Laurent Le Corre, Waldemar Vollmer, Nicolas Pietrancosta, Leiv Sigve Håvarstein, André Zapun

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

The amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, whic

Externí odkaz: https://doaj.org/article/4e8f7d6353d84e29a4d53b28f4a9d9e8

Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system.

Autor: S Peter Howard, Leandro F Estrozi, Quentin Bertrand, Carlos Contreras-Martel, Timothy Strozen, Viviana Job, Alexandre Martins, Daphna Fenel, Guy Schoehn, Andréa Dessen

Publikováno v: PLoS Pathogens, Vol 15, Iss 5, p e1007731 (2019)

The type II secretion system (T2SS) is a cell envelope-spanning macromolecular complex that is prevalent in Gram-negative bacterial species. It serves as the predominant virulence mechanism of many bacteria including those of the emerging human patho

Externí odkaz: https://doaj.org/article/d98db94422e548828023526a1ad86f00

Structural-functional analysis of the oligomeric protein R-phycoerythrin

Autor: JOSÉ MARTÍNEZ-OYANEDEL, CARLOS CONTRERAS-MARTEL, CAROLA BRUNA, MARTA BUNSTER

Publikováno v: Biological Research, Vol 37, Iss 4, Pp 733-745 (2004)

The structure of phycobiliproteins and their spatial organization in the phycobilisome provide the environment for high efficiency in light harvesting and conduction towards photosystem II. This article focuses on the analysis of R-phycoerythrin, a l

Externí odkaz: https://doaj.org/article/1b6b6430ca6a41dca343e23295527ea7

Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin

Autor: Sarah Bonhomme, Carlos Contreras-Martel, Andréa Dessen, Pauline Macheboeuf

Publikováno v: Structure
Structure, 2023, 31 (6), pp.700-712.e4. ⟨10.1016/j.str.2023.03.012⟩
Structure, 2023, pp.S0969-2126(23)00095-3. ⟨10.1016/j.str.2023.03.012⟩

International audience; The genotoxin colibactin produced by Escherichia coli is involved in the development of colorectal cancers. This secondary metabolite is synthesized by a multi-protein machinery, mainly composed of non-ribosomal peptide synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf0e2e799d500a8ffe098b4e7e78776
https://hal.science/hal-04162888