Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection

Autor: Javier Gutiérrez-Álvarez, José M. Honrubia, Raúl Fernández-Delgado, Li Wang, Carlos Castaño-Rodríguez, Sonia Zúñiga, Isabel Sola, Luis Enjuanes

Publikováno v: mBio, Vol 12, Iss 2 (2021)

The emergence of the new highly pathogenic human coronavirus SARS-CoV-2 that has already infected more than 80 million persons, killing nearly two million of them, clearly indicates the need to design efficient and safe vaccines protecting from these

Externí odkaz: https://doaj.org/article/c01fb9a68b5a453eacd5373a7db07a1d

Viral PDZ Binding Motifs Influence Cell Behavior Through the Interaction with Cellular Proteins Containing PDZ Domains

Autor: Isabel Sola, Carlos Castaño-Rodríguez, Javier Gutiérrez-Álvarez, Luis Enjuanes, José M. Honrubia

Publikováno v: Methods in Molecular Biology ISBN: 9781071611654

Viruses have evolved to interact with their hosts. Some viruses such as human papilloma virus, dengue virus, SARS-CoV, or influenza virus encode proteins including a PBM that interact with cellular proteins containing PDZ domains. There are more than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85a11bbd41b4512ddc86aa3abf74dce5
https://doi.org/10.1007/978-1-0716-1166-1_13

Relevance of coronavirus viroporins and pdz-binding- motifs in virus replication and virulence

Autor: María Queralt-Martín, Luis Enjuanes Sánchez, Vicente M. Aguilella, Raúl Fernandez-Delgado, J. P. Borg, José M. Honrubia, Stanley Perlman, Carmina Verdiá-Báguena, Isabel Solá Gurpegui, Carlos Castaño-Rodríguez, E. Bailly, P. Zimmermann, Francisco J. Gutierrez-Alvarez

Publikováno v: IBJ Plus.

Trabajo presentado en el 37th Annual Meeting American Society for Virology Symposia, celebrado en Maryland (Estados Unidos), del 14 al 18 de julio de 2018

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::745c2c1e42c779df404b3a1403d46d0f
https://doi.org/10.24217/2531-0151.18v1s2.00018

Role of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and pathogenesis

Autor: Grazyna Kochan, Stanley Perlman, Luis Enjuanes, Marta L. DeDiego, Jose L. Nieto-Torres, Vicente M. Aguilella, Raúl Fernandez-Delgado, Jose M. Jimenez-Guardeño, Jose Angel Regla-Nava, Javier Gutiérrez-Álvarez, María Queralt-Martín, José M. Honrubia, Isabel Sola, Carlos Castaño-Rodríguez, Carmina Verdiá-Báguena

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
mBio, Vol 9, Iss 3 (2018)
mBio, Vol 9, Iss 3, p e02325-17 (2018)
Repositori Universitat Jaume I
Universitat Jaume I
mBio

Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis. While many coronaviruses (CoVs) encode two viroporins, severe acute respiratory syndrome CoV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99193b7b54334179c1bb68d94f0c619d
http://hdl.handle.net/10261/204381

Inhibition of NF-κB-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival

Autor: Stanley Perlman, Jose M. Jimenez-Guardeño, Luis Enjuanes, Jose L. Nieto-Torres, Marta L. DeDiego, Jose Angel Regla-Nava, Carlos Castaño-Rodríguez, Craig Fett, Raúl Fernandez-Delgado

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Virology
Journal of Virology; Vol 88

Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV lacking the E gene (SARS-CoV-¿E) is attenuated in several animal model syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817b7bf0e09b396fe7baa53fd4ad4212
https://doi.org/10.1128/jvi.02576-13