Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Carlos B Duarte"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108175 (2014)
Dendritic protein synthesis plays a critical role in several forms of synaptic plasticity, including BDNF (brain-derived neurotrophic factor)-mediated long-term synaptic potentiation (LTP). Dendritic transcripts are typically transported in a repress
Externí odkaz:
https://doaj.org/article/d3b71e8bbdaa45dc91aa895ad345bde8
Autor:
Joana Fernandes, Marta Vieira, Laura Carreto, Manuel A S Santos, Carlos B Duarte, Ana Luísa Carvalho, Armanda E Santos
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99958 (2014)
Transient global cerebral ischemia induces profound changes in the transcriptome of brain cells, which is partially associated with the induction or repression of genes that influence the ischemic response. However, the mechanisms responsible for the
Externí odkaz:
https://doaj.org/article/41418ec81e704b429a92dce15ed2230f
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53793 (2013)
BDNF is a pro-survival protein involved in neuronal development and synaptic plasticity. BDNF strengthens excitatory synapses and contributes to LTP, presynaptically, through enhancement of glutamate release, and postsynaptically, via phosphorylation
Externí odkaz:
https://doaj.org/article/1368c2629e274c7e8971238ab94100df
Autor:
Márcio S Baptista, Carlos V Melo, Mário Armelão, Dennis Herrmann, Diogo O Pimentel, Graciano Leal, Margarida V Caldeira, Ben A Bahr, Mário Bengtson, Ramiro D Almeida, Carlos B Duarte
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10139 (2010)
Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms--GAD65 and GAD67. The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional c
Externí odkaz:
https://doaj.org/article/9513d2b9c41945138b839630244cf091
Autor:
Inês Caramelo, Margarida Coelho, Miguel Rosado, Carla M. P. Cardoso, Alexandra Dinis, Carlos B. Duarte, Mário Grãos, Bruno Manadas
Publikováno v:
World Journal of Pediatrics. 19:505-548
Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement tools. Therefore, this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical pr
Publikováno v:
Molecular Neurobiology. 60:3507-3521
Learned fear is orchestrated by a brain fear network that comprises the amygdala, hippocampus and the medial prefrontal cortex. Synaptic plasticity within this network is critical for the formation of proper fear memories. Known for their role in the
Autor:
Elisa Corti, Carlos B. Duarte
Publikováno v:
Biochemical Society Transactions. 51:315-330
AMPA-type receptors for the neurotransmitter glutamate are very dynamic entities, and changes in their synaptic abundance underlie different forms of synaptic plasticity, including long-term synaptic potentiation (LTP), long-term depression (LTD) and
Publikováno v:
Journal of Molecular Neuroscience. 72:1500-1515
Epilepsy is a neurological disease characterized by abnormal or synchronous brain activity causing seizures, which may produce convulsions, minor physical signs, or a combination of symptoms. These disorders affect approximately 65 million people wor
Autor:
Sara R. Oliveira, João Castelhano, José Sereno, Lorena Petrella, Miguel Castelo-Branco, Helena L. A. Vieira, Carlos B. Duarte
Although stroke is the main cause of brain damage worldwide, stroke therapies are based on blood reperfusion and do not target cerebral parenchyma. Ischemic stroke (representing 87% of all strokes) causes cerebral damage due to oxygen and tissue ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b9777f366f511b09ec175f015461d7
https://doi.org/10.1101/2022.11.10.515956
https://doi.org/10.1101/2022.11.10.515956
Autor:
Carlos B. Duarte, Miguel Castelo-Branco, Sara Oliveira, José Sereno, Helena L. A. Vieira, João Castelhano
Publikováno v:
European Journal of Neuroscience. 52:2771-2780
Previous studies about the modulation of the vasculature by CO were performed exclusively in male or sexually immature animals. Understanding the sex differences regarding systemic drug processing and pharmacodynamics is an important feature for safe