Soluble epoxide hydrolase inhibition enhances Specialized Pro-resolving Lipid Mediator production and promotes macrophage plasticity

Autor: Henrique B, Abdalla, Carla, Alvarez, Yu-Chiao, Wu, Paola, Rojas, Bruce D, Hammock, Krishna R, Maddipati, Carlos Antonio, Trindade-da-Silva, Mariana Q S, Soares, Juliana T, Clemente-Napimoga, Alpdogan, Kantarci, Marcelo H, Napimoga, Thomas E, Van Dyke

Publikováno v: British journal of pharmacology.

Epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFA) are lipid mediators that are rapidly inactivated by soluble epoxide hydrolase. Uncontrolled and chronic inflammatory disorders fail to sufficiently activate endogenous regulatory pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7ca77ed6d704b6b86f4798cb08f628b
https://pubmed.ncbi.nlm.nih.gov/36508312

The Modulatory Effect of 15d-PGJ2 in Dendritic Cells

Autor: Antonio José de Pinho, Thais S. Farnesi-de-Assunção, Marcelo Henrique Napimoga, Vanessa Carregaro, Carlos Antonio Trindade da Silva

Publikováno v: Nuclear Receptor Research, Vol 1, Pp 1-7 (2014)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The PPAR-γ ligands, in special 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2), negatively regulate the cells of innate and adaptative immune system and present excellent results in different models of inflammatory diseases. These findings support the notion that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2b85a9ffef57e3f15a29d520088041
http://www.kenzpub.com/journals/nurr/2014/101083/

Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis

Autor: Kin Sing Stephen Lee, Marcelo Henrique Napimoga, Bruce D. Hammock, Fawaz G. Haj, Donald A. Bruun, Bora Inceoglu, Carlos Antonio Trindade-da-Silva, Ahmed Bettaieb, Sumanta Kumar Goswami, Carlos Ueira-Vieira

Publikováno v: The Journal of pharmacology and experimental therapeutics, vol 361, iss 3

Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid derived from the cytochrome P450 enzymes, are mainly metabolized by soluble epoxide hydrolase (sEH) to their corresponding diols. EETs but not their diols, have anti-inflammatory prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0f209da056337cf74807d8346053e1
https://pubmed.ncbi.nlm.nih.gov/28356494

PPAR-γ agonists, mainly 15d-PGJ2, reduce eosinophil recruitment following allergen challenge

Autor: Fernando Q. Cunha, Claudiney F. Alves, Jhony Robison de Oliveira, Vanessa Carregaro, Thais S. Farnesi-de-Assunção, Marcelo Henrique Napimoga, Carlos Antonio Trindade da Silva, Alessandra B. Cheraim

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

We evaluate the immunomodulation of Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists 15d-PGJ(2) and rosiglitazone (RGZ) in a model of chronic eosinophilia. 15d-PGJ(2) and RGZ significantly reduce eosinophil migration into the peritone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e0afc2d4a7535ad0254a2e4e591902
https://doi.org/10.1016/j.cellimm.2011.11.010

Interleukin-6, tumor necrosis factor-α, C-reactive protein, and hematological parameters in experimental periodontal disease after β-adrenergic blockade

Autor: Wellington Francisco Rodrigues, Camila Botelho Miguel, Javier Emilio Lazo-Chica, Carlos Antônio Trindade da Silva, Carlos Ueira Vieira, Juliana Trindade Clemente-Napimoga, Carlo José Freire Oliveira, Marcelo Henrique Napimoga

Publikováno v: Journal of Indian Society of Periodontology, Vol 23, Iss 6, Pp 511-516 (2019)

Background: Changes in the levels of C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) observed during periodontal disease were linked with vascular manifestations. Recent studies showed that the beta-blocker propr

Externí odkaz: https://doaj.org/article/d0b4078655bc49dfb548c1552d803d9e