Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Carlos Alberto Montanari"'
Autor:
Daniel Ken Inaoka, Maiko Iida, Toshiyuki Tabuchi, Teruki Honma, Nayoung Lee, Satoshi Hashimoto, Shigeru Matsuoka, Takefumi Kuranaga, Kazuhito Sato, Tomoo Shiba, Kimitoshi Sakamoto, Emmanuel Oluwadare Balogun, Shigeo Suzuki, Takeshi Nara, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Akiko Tanaka, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167078 (2016)
Many open form (OF) structures of drug targets were obtained a posteriori by analysis of co-crystals with inhibitors. Therefore, obtaining the OF structure of a drug target a priori will accelerate development of potent inhibitors. In addition to its
Externí odkaz:
https://doaj.org/article/3a23ea416020435288da3735a0f01c84
Autor:
Láuris Lucia da Silva, Claudio Luis Donnici, Júlio César Dias Lopes, Marília Oliveira Fonseca Goulart, Fabiane Caxico de Abreu, Francine Santos de Paula, Carlos E. Salas Bravo, Marcelo Matos Santoro, Ângelo Márcio Leite Denadai, Alexandre Martins Costa Santos, Carlos Alberto Montanari
Publikováno v:
Química Nova, Vol 35, Iss 7, Pp 1318-1324 (2012)
Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases. Two new biscationic compounds (bis-α,ω-S-thioureido, amino and sulfide analogues) were synthesized in good yields and fully ch
Externí odkaz:
https://doaj.org/article/167023fba63640db9a804bdb638d2eeb
Autor:
Ryunosuke Yoshino, Nobuaki Yasuo, Daniel Ken Inaoka, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Tomoo Shiba, Shigeharu Harada, Teruki Honma, Emmanuel Oluwadare Balogun, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Kiyoshi Kita, Masakazu Sekijima
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125829 (2015)
Chagas disease, caused by the parasite Trypanosoma cruzi, is a neglected tropical disease that causes severe human health problems. To develop a new chemotherapeutic agent for the treatment of Chagas disease, we predicted a pharmacophore model for T.
Externí odkaz:
https://doaj.org/article/4b0bac0f018a4bb7a714642595f2c480
Autor:
Vera Lúcia de Almeida, Andrei Leitão, Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Míriam Teresa Paz Lopes
Publikováno v:
Química Nova, Vol 28, Iss 1, Pp 118-129 (2005)
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthe
Externí odkaz:
https://doaj.org/article/9641afe022344144b65ee19de0a11289
Publikováno v:
Química Nova, Vol 25, Iss suppl 1, Pp 39-44 (2002)
Externí odkaz:
https://doaj.org/article/aa61f2966bcc4458b49d77c0d33eec0f
Publikováno v:
Química Nova, Vol 25, Iss 3, Pp 439-448 (2002)
The process of building mathematical models in quantitative structure-activity relationship (QSAR) studies is generally limited by the size of the dataset used to select variables from. For huge datasets, the task of selecting a given number of varia
Externí odkaz:
https://doaj.org/article/030c96f0ff2949cd8e858cae7fca6e27
Autor:
Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Izaura Cirino Nogueira Diógenes, Ícaro de Sousa Moreira
Publikováno v:
Química Nova, Vol 25, Iss 1, Pp 5-9 (2002)
Externí odkaz:
https://doaj.org/article/b3bd876fbd23495aaf794f143430fb0e
Publikováno v:
Química Nova, Vol 24, Iss 1, Pp 105-111 (2001)
Externí odkaz:
https://doaj.org/article/761662b807504c6081549a9c1348a87c
Autor:
Maria Luiza C. Montanari, Carlos Alberto Montanari, Dorila Piló-Veloso, A. E. Beezer, J. C. Mitchell
Publikováno v:
Química Nova, Vol 21, Iss 4, Pp 470-476 (1998)
Drug delivery system controls the distribution of drugs for optimal therapeutic efficacy. The complex of higly active drugs with macromolecular carriers seems to offer a promising way to optimize their delivery. Dendrimers can be used as drug deliver
Externí odkaz:
https://doaj.org/article/2ce2c36c2a854cdc93b18409f48465f3
Publikováno v:
Journal of computer-aided molecular design. 16(4)
The interest in the non-nucleoside inhibitors (NNIs) to the reverse transcriptase (RT) as anti-AIDS agents has grown in the last ten years. The compound 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) is the precursor of the most studied cla