Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Carlos Alberto Manssour, Fraga"'
Autor:
Lucas Silva Franco, Bárbara da Silva Mascarenhas de Jesus, Pedro de Sena Murteira Pinheiro, Carlos Alberto Manssour Fraga
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 742 (2024)
This work examines the current landscape of drug discovery and development, with a particular focus on the chemical and pharmacological spaces. It emphasizes the importance of understanding these spaces to anticipate future trends in drug discovery.
Externí odkaz:
https://doaj.org/article/703dc88bbcd0466e871da476c9008eff
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1157 (2023)
One of the key scientific aspects of small-molecule drug discovery and development is the analysis of the relationship between its chemical structure and biological activity. Understanding the effects that lead to significant changes in biological ac
Externí odkaz:
https://doaj.org/article/2c04062d0231415497e0025725ccaaec
Publikováno v:
Molecules, Vol 28, Iss 2, p 838 (2023)
Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature provides much information about the synthesis, functionalization, p
Externí odkaz:
https://doaj.org/article/23e33ed504cf45f6b97fe0cca4b0ccb6
Autor:
Dayana da Costa Salomé, Rosana Helena Coimbra Nogueira de Freitas, Carlos Alberto Manssour Fraga, Patricia Dias Fernandes
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13562 (2022)
Background: When homeostasis is disturbed it can result in a pathological event named inflammation. The main drugs used in the treatment consist of non-steroidal and steroidal anti-inflammatory drugs. However, the side effects remain an obstacle duri
Externí odkaz:
https://doaj.org/article/aed19dc016b84ce6b3ed99b6a0a8edd8
Autor:
Thayssa Tavares da Silva Cunha, Rafaela Ribeiro Silva, Daniel Alencar Rodrigues, Pedro de Sena Murteira Pinheiro, Thales Kronenberger, Carlos Maurício R. Sant’Anna, François Noël, Carlos Alberto Manssour Fraga
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1112 (2022)
Most neurodegenerative diseases are multifactorial, and the discovery of several molecular mechanisms related to their pathogenesis is constantly advancing. Dopamine and dopaminergic receptor subtypes are involved in the pathophysiology of several ne
Externí odkaz:
https://doaj.org/article/13ab0bb4c89448e6a0ffe44b9807756c
Autor:
Grazielle Fernandes Silva, Jaqueline Soares da Silva, Allan Kardec Nogueira de Alencar, Marina de Moraes Carvalho da Silva, Tadeu Lima Montagnoli, Bruna de Souza Rocha, Rosana Helena Coimbra Nogueira de Freitas, Roberto Takashi Sudo, Carlos Alberto Manssour Fraga, Gisele Zapata-Sudo
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 900 (2022)
Mitogen-activated protein kinase (MAPK) signaling is strongly implicated in cardiovascular remodeling in pulmonary hypertension (PH) and right ventricle (RV) failure. The effects of a newly designed p38 inhibitor, LASSBio-1824, were investigated in e
Externí odkaz:
https://doaj.org/article/240de6e839fb4bd794f614d86133dbcc
Autor:
Natalia de Morais Cordeiro, Rosana H.C.N. Freitas, Carlos Alberto Manssour Fraga, Patricia Dias Fernandes
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 123, Iss , Pp 109739- (2020)
Aims: The main aim of this paper was the synthesis and the evaluation of the anti-inflammatory activity of LASSBio-1828 (an amino-pyridinyl-N-acylhydrazone) and its respective hydrochloride, based on a p38α MAPK inhibitor (LASSBio-1824) previously s
Externí odkaz:
https://doaj.org/article/edb42fb88d51426d8f0fe506a41d82eb
Autor:
Ramon Guerra de Oliveira, Fabiana Sélos Guerra, Cláudia dos Santos Mermelstein, Patrícia Dias Fernandes, Isadora Tairinne de Sena Bastos, Fanny Nascimento Costa, Regina Cely Rodrigues Barroso, Fabio Furlan Ferreira, Carlos Alberto Manssour Fraga
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1181-1193 (2018)
In this study, we synthesized a new congener series of N-sulphonylhydrazones designed as candidate ROCK inhibitors using the molecular hybridization of the clinically approved drug fasudil (1) and the IKK-β inhibitor LASSBio-1524 (2). Among the synt
Externí odkaz:
https://doaj.org/article/d73b148125364d7da3c2636102c54a57
Autor:
Jéssica de Siqueira Guedes, Teiliane Rodrigues Carneiro, Pedro de Sena Murteira Pinheiro, Carlos Alberto Manssour Fraga, Carlos Mauricio R. Sant′Anna, Eliezer J. Barreiro, Lídia Moreira Lima
Publikováno v:
ACS Omega. 7:38752-38765
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379577c4b5a866123e17bc4a39d5b4d0
https://doi.org/10.1021/acsomega.2c04368
https://doi.org/10.1021/acsomega.2c04368
Autor:
Fabiana Sélos Guerra, Daniel Alencar Rodrigues, Carlos Alberto Manssour Fraga, Patricia Dias Fernandes
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 387 (2021)
Background: Prostate cancer is the second most frequently diagnosed malignancy worldwide. Here, the cytotoxic and antimetastatic effects of a new HDAC6/8 inhibitor, LASSBio-1911, and a new dual-PI3K/HDAC6 inhibitor, LASSBio-2208, were evaluated again
Externí odkaz:
https://doaj.org/article/4085331ebd6b4373b8834c8d13d55de8