Výsledky vyhledávání - "Carlos AZ Bassetto"

Akademický článek

Isoleucine gate blocks K+ conduction in C-type inactivation

Autor: Werner Treptow, Yichen Liu, Carlos AZ Bassetto, Bernardo I Pinto, Joao Antonio Alves Nunes, Ramon Mendoza Uriarte, Christophe J Chipot, Francisco Bezanilla, Benoit Roux

Publikováno v: eLife, Vol 13 (2024)

Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the sel

Externí odkaz: https://doaj.org/article/33e5fb7e585748c49798626eae8ebd47

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Akademický článek

Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels

Autor: Carlos AZ Bassetto, João Luis Carvalho-de-Souza, Francisco Bezanilla

Publikováno v: eLife, Vol 10 (2021)

In Shaker K+ channels, the S4-S5 linker couples the voltage sensor (VSD) and pore domain (PD). Another coupling mechanism is revealed using two W434F-containing channels: L361R:W434F and L366H:W434F. In L361R:W434F, W434F affects the L361R VSD seen a

Externí odkaz: https://doaj.org/article/4a8f26c6723e401f90ae49dd4e0d2b44

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A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na (+) Channels

Autor: Yichen Liu, Carlos AZ Bassetto, Bernardo I Pinto, Francisco Bezanilla

Publikováno v: bioRxiv

Fast Inactivation in voltage-gated Na+channels plays essential roles in numerous physiological functions. The canonical hinged-lid model has long predicted that a hydrophobic motif in the DIII-DIV linker (IFM) acts as the gating particle that occlude

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c013666c3dc13847521ca9e25e535e03
https://europepmc.org/articles/PMC10168311/

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