Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Carlos A. Velázquez-Martínez"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5067 (2024)
Ovarian cancer is the deadliest gynecologic malignancy. The majority of patients diagnosed with advanced ovarian cancer will relapse, at which point additional therapies can be administered but, for the most part, these are not curative. As such, a n
Externí odkaz:
https://doaj.org/article/7fdff170fa594c8389d87770cf1cccf0
Autor:
César Sebastian Huerta-García, David J. Pérez, Carlos A. Velázquez-Martínez, Seyed Amirhossein Tabatabaei Dakhili, Antonio Romo-Mancillas, Rafael Castillo, Alicia Hernández-Campos
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 283 (2022)
We report synthesis, characterization, biological evaluation, and molecular-docking studies of 18 thieno[2,3-b]pyridines with a phenylacetamide moiety at position 2, which is disubstituted with F, Cl, Br, or I at position 4, and with electron-withdra
Externí odkaz:
https://doaj.org/article/9b1f37ab697c41fdbe4b1250007097b7
Autor:
Carlos A. Velázquez-Martínez, Guoshun Luo, Guolong Li, Antonio Vega-Medina, Hua Xiang, Hanlin Wei, Maoxu Xiao, Xin Lin
Publikováno v:
Journal of Medicinal Chemistry. 64:17098-17114
The transcription factor FOXM1 that regulates multiple proliferation-related genes through selective protein-DNA and protein-protein interactions is now considered an attractive oncotarget. There are several small-molecule inhibitors that indirectly
Autor:
Sergey Gusarov, Norio Yoshida, Alexander E. Kobryn, Yutaka Maruyama, Carlos A. Velázquez-Martínez
The angiotensin-converting enzyme 2 (ACE2) protein is a cell gate receptor for the SARS-CoV-2 virus, responsible for the development of symptoms associated with the Covid-19 disease. Pharmacological inhibition of the SARS-CoV-2 spike receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a2f9e2850bd2c11f795fd39ae7e636
https://nrc-publications.canada.ca/eng/view/object/?id=358edb87-168d-4c46-b833-e5015e314a27
https://nrc-publications.canada.ca/eng/view/object/?id=358edb87-168d-4c46-b833-e5015e314a27
Autor:
Lindsey Y.K. Suh, Lusine Tonoyan, S. Amirhossein Tabatabaei-Dakhili, Arno G. Siraki, Andrew G.M. Morgan, Randy M. Whittal, Béla Reiz, Dinesh Babu, Carlos A. Velázquez-Martínez
Publikováno v:
Free Radical Biology and Medicine. 143:422-432
Edaravone is considered to be a potent antioxidant drug known to scavenge free radical species and prevent free radical-induced lipid peroxidation. In this study, we investigated the effect of edaravone on the myeloperoxidase (MPO) activity, an enzym
Autor:
Jennifer Dufour, Seyed Amirhossein Tabatabaei Dakhili, Melinda Wuest, Frank Wuest, David J. Pérez, Carlos A. Velázquez-Martínez, Cody Bergman, Freimut D Juengling
Publikováno v:
ChemMedChem. 16(24)
The FOXM1 protein controls the expression of essential genes related to cancer cell cycle progression, metastasis, and chemoresistance. We hypothesize that FOXM1 inhibitors could represent a novel approach to develop 18 F-based radiotracers for Posit
Autor:
Eder Arredondo Espinoza, Eugenio Hernández-Fernández, Verónica M. Rivas-Galindo, Erika L. Loredo-Calderón, Carlos A. Velázquez-Martínez, Mónica A. Ramírez-Cabrera, Susana T. López-Cortina
Publikováno v:
Medicinal Chemistry Research. 28:2067-2078
The synthesis of two series of α-aminophosphonates was achieved by Microwave Irradiation (MW), using the one-pot Kabachnik–Fields reaction. Based on a green chemistry approach, the reactions were carried out using ethanol as the only solvent and w
Autor:
Khosrow Kashfi, Moinul Haque, Seyed Amirhossein Tabatabaei Dakhili, Keshav Gopal, John R. Ussher, David J. Pérez, Carlos A. Velázquez-Martínez
Publikováno v:
European journal of medicinal chemistry. 209
This research article describes an approach to modify the thiazolidinedione scaffold to produce test drugs capable of binding to, and inhibit, the in vitro transcriptional activity of the oncogenic protein FOXM1. This approach allowed us to obtain FO
Autor:
Jason R.B. Dyck, Fahad S. Aldawsari, Basil P. Hubbard, Yoke Wong, Carlos A. Velázquez-Martínez, Evan Kerek, Khushwant S. Bhullar, Vrajesh Pandya, Robyn Losch, Joe Ou, Mohamed Salla, Aducio Thiesen, Shairaz Baksh
Publikováno v:
Molecules
Volume 25
Issue 17
Molecules, Vol 25, Iss 3849, p 3849 (2020)
Volume 25
Issue 17
Molecules, Vol 25, Iss 3849, p 3849 (2020)
Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It is one of the most promising natural molecules in the prevention and treatment of chronic diseases and autoimmun
Autor:
Carlos Alberto Velázquez Martínez, Seyed Amirhossein Tabatabaei Dakhili, John R. Ussher, Keshav Gopal, David J. Pérez
Publikováno v:
Proceedings, Vol 22, Iss 1, p 58 (2019)
The Forkhead boX M1 (FOXM1) is an essential transcription factor for normal activation of the cell cycle and cell replication. However, increasing evidence suggests that overexpression of this protein correlates with cancer development and poor patie