Výsledky vyhledávání - "Carlos A. Puyo"

N-Acetylcysteine to Combat COVID-19: An Evidence Review

Publikováno v: Therapeutics and Clinical Risk Management. 16:1047-1055

The novel coronavirus disease (COVID-19) is caused by a virus (SARS-Cov-2) and is known for inducing multisystem organ dysfunction associated with significant morbidity and mortality. Current therapeutic strategies for COVID-19 have failed to effecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c677deb55bf75e3b174ca6e87aae5f9b
https://doi.org/10.2147/tcrm.s273700

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Endotracheal intubation results in acute tracheal damage induced by mtDNA/TLR9/NF‐κB activity

Autor: Michael M. Awad, Carlos A. Puyo, Alexander Earhart, Marin H. Kollef, Nicholas Staten, Colleen Haug, Oliver A. Prince

Publikováno v: Journal of Leukocyte Biology

Tracheitis secondary to placement of an endotracheal tube (ETT) is characterized by neutrophil accumulation in the tracheal lumen, which is generally associated with epithelial damage. Mitochondrial DNA (mtDNA), has been implicated in systemic inflam

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http://europepmc.org/articles/PMC7379990

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Mitochondrial DNA induces Foley catheter related bladder inflammation via Toll-like receptor 9 activation

Autor: Carlos A. Puyo, Alexander Earhart, H. Henry Lai, Ramakrishna Venkatesh, Nicholas Staten, Alana Desai, Yuan Huang

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports

Bladder instrumentation engages the innate immune system via neutrophil activation, promoting inflammation and pain. Elevated levels of mitochondrial DNA (mtDNA) have been associated with tissue damage and organ dysfunction. We hypothesized that loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74697baa4383c63294608a8a31173aa0
http://link.springer.com/article/10.1038/s41598-018-24818-w

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PD38-12 EFFECTS OF DRUG COATED URETERAL STENT ON URETERAL INFLAMMATION AND URINARY INFLAMMATORY MARKERS IN AN IN VIVO PORCINE MODEL

Autor: Ramakrishna Venkatesh, Michael Talcott, Colleen Haug, Suellen Greco, Neel Raval, Nick Staten, Carlos A. Puyo

Publikováno v: Journal of Urology. 201

INTRODUCTION AND OBJECTIVES:The basic mechanisms of ureteral stent morbidity is not well understood. Reducing the inflammatory process associated with a stent may decrease symptoms related to urete...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4694461ea31af623b91bebc796bdafbc
https://doi.org/10.1097/01.ju.0000556380.40007.1e

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Case Report: Use of hydroxychloroquine and N-acetylcysteine for treatment of a COVID-19 patient

Autor: Essam Ansari, Danielle Kreig, Venugopal Saddi, Carlos A Puyo, Oliver A. Prince

Publikováno v: F1000Research. 9:491

There is worldwide concern for lack of specific therapy against the novel Betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This case report presents the results of a pharmacological intervention aimed at modulating the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f1193b2dd831ee3ea499361757dd957
https://doi.org/10.12688/f1000research.23995.2

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Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA

Autor: Daniel Kreisel, Daniela Peruzzi, Evan Roller, Alexander S. Krupnick, Menelaos Karanikolas, Mohsen Ibrahim, Marin H Kollef, Andrew E. Gelman, Carlos A. Puyo, Alexander Earhart

Publikováno v: Molecular Pain

In the absence of infection, the pathophysiology of endotracheal tube-induced sore throat pain is unclear. Activated neutrophils release elastase, reactive oxygen species, and inflammatory cytokines known to contribute to neuropathic pain. Sterile ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de24dc0dce51ef0b0d3f5d72fcafa5cc
http://hdl.handle.net/11573/1017769

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Does a Multimodal No-Compression Suture Technique of the Intercostal Space Reduce Chronic Postthoracotomy Pain? A Prospective Randomized Study

Autor: Carlos A. Puyo, Domenico Massullo, Mohsen Ibrahim, Rossella Baldini, Erino A. Rendina, Antonio D'Andrilli, Giulio Maurizi, Anna Maria Ciccone, Cecilia Menna, Claudio Andreetti, Camilla Vanni, Giammauro Berardi

Publikováno v: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 11(9)

Introduction Chronic postthoracotomy pain is a significant adverse outcome of thoracic surgery. We evaluated with a prospective randomized trial the effect of a multimodal no-compression suture technique of the intercostal space on postoperative pain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98200b44eb5ee81ec8976a20e9e4a3cb
https://pubmed.ncbi.nlm.nih.gov/27282308

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Human Recombinant Apyrase Therapy Protects Against Canine Pulmonary Ischemia-Reperfusion Injury

Autor: Ramsey R. Hachem, Xingan Wang, Alexander S. Krupnick, Alessandro Montecalvo, Cecilia Menna, Andrew E. Gelman, Carlos A. Puyo, Howard J. Huang, Mohsen Ibrahim, Ridong Chen, Daniel Kreisel, Claudio Andreetti, Erino A. Rendina

Background There is accumulating evidence that extracellular adenosine triphosphate (eATP) promotes many of the underlying mechanisms that exacerbate acute lung injury. However, much of these data are from inbred rodent models, indicating the need fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e86f4eae4413bd092241d2f59f909c8
http://hdl.handle.net/11573/617409

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