Zobrazeno 1 - 10
of 462
pro vyhledávání: '"Carlos A. M. Afonso"'
Autor:
Dídia Sousa, Milene A. G. Fortunato, Joana Silva, Mónica Pingo, Alice Martins, Carlos A. M. Afonso, Rui Pedrosa, Filipa Siopa, Celso Alves
Publikováno v:
Marine Drugs, Vol 22, Iss 9, p 408 (2024)
Sphaerococcenol A is a cytotoxic bromoditerpene biosynthesized by the red alga Sphaerococcus coronopifolius. A series of its analogues (1–6) was designed and semi-synthesized using thiol-Michael additions and enone reduction, and the structures of
Externí odkaz:
https://doaj.org/article/8dff4be841094cd1ae26d0ba83fb6121
Autor:
Celso Martins, Diego O. Hartmann, Adélia Varela, Jaime A. S. Coelho, Pedro Lamosa, Carlos A. M. Afonso, Cristina Silva Pereira
Publikováno v:
Microbial Biotechnology, Vol 13, Iss 6, Pp 1983-1996 (2020)
Summary Hydroxymethylfurfural (HMF) is a promising lignocellulosic‐derived source for the generation of diverse chemical building blocks constituting an alternative to fossil fuels. However, it remains unanswered if ubiquitous fungi can ensure thei
Externí odkaz:
https://doaj.org/article/76a846a0980b49b2a1f66e590649d35c
Autor:
Stella Parmaki, Argyro Tsipa, Marlen I. Vasquez, João M. J. Gonçalves, Ioanna Hadjiadamou, Frederico C. Ferreira, Carlos A. M. Afonso, Chrysoulla Drouza, Michalis Koutinas
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background Lupanine is a plant toxin contained in the wastewater of lupine bean processing industries, which could be used for semi-synthesis of various novel high added-value compounds. This paper introduces an environmental friendly proces
Externí odkaz:
https://doaj.org/article/2d6fd670770d468ab194ab4dfea0896f
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 97 (2022)
Nitrogen-containing heterocycles can have several applications in the pharmaceutical industry since they contain a wide spectrum of biological activities. Imidazolidinones have shown activity against leukemia, lung cancer, and metabolic disorders. Th
Externí odkaz:
https://doaj.org/article/ed79344bcecf4238b9fe6e5726cad86f
Autor:
Filipa Siopa, Raquel F. M. Frade, Ana Diniz, Joana M. Andrade, Marisa Nicolai, Ana Meirinhos, Susana D. Lucas, Filipa Marcelo, Carlos A. M. Afonso, Patrícia Rijo
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 17145-17154 (2018)
Externí odkaz:
https://doaj.org/article/2e72d255b9eb499c993fcadb5f2d07fa
Publikováno v:
Molbank, Vol 2021, Iss 2, p M1199 (2021)
Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-(
Externí odkaz:
https://doaj.org/article/5643f6f1217f48c2b605aa0a8fed27e9
Publikováno v:
Molecules, Vol 27, Iss 5, p 1673 (2022)
The presence of sulfur–carbon bonds is transversal to several areas of chemistry, e.g., drug discovery, materials, and chemical biology. However, a lack of efficient and sustainable procedures for the preparation of thioaminals, the N,S-analogues o
Externí odkaz:
https://doaj.org/article/e22e79b594924c8aa6e63752ca068501
Autor:
Catarina Garcia, Vera M. S. Isca, Filipe Pereira, Carlos M. Monteiro, Epole Ntungwe, Francisco Sousa, Jelena Dinic, Suvi Holmstedt, Amílcar Roberto, Ana Díaz-Lanza, Catarina P. Reis, Milica Pesic, Nuno R. Candeias, Ricardo J. Ferreira, Noélia Duarte, Carlos A. M. Afonso, Patrícia Rijo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Cancer is among the leading causes of death worldwide. One of the most challenging obstacles in cancer treatment is multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp) is associated with MDR. The growing incidence of cancer and the de
Externí odkaz:
https://doaj.org/article/e0c57d17a6814473b2b968463276ad86
Autor:
Anisha Viswanathan, Aliyu Musa, Akshaya Murugesan, João R. Vale, Carlos A. M. Afonso, Saravanan Konda Mani, Olli Yli-Harja, Nuno R. Candeias, Meenakshisundaram Kandhavelu
Publikováno v:
Cells, Vol 9, Iss 12, p 2631 (2020)
There is an error in the title of the paper [...]
Externí odkaz:
https://doaj.org/article/dd09adfd933a4444ae9d4959ad65db89
Autor:
Isabel Martins, Adélia Varela, Luís M. T. Frija, Mónica A. S. Estevão, Sébastien Planchon, Jenny Renaut, Carlos A. M. Afonso, Cristina Silva Pereira
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 5 (2017)
Plant terpenoids compose a natural source of chemodiversity of exceptional value. Many of these compounds own biological/pharmacological activity, others are regarded as unique chemical skeletons for the synthesis of derivatives with improved propert
Externí odkaz:
https://doaj.org/article/54189eb020de4e1eb08c78e0c5aea49b