Zobrazeno 1 - 10
of 465
pro vyhledávání: '"Carlos A. M. Afonso"'
Autor:
Dídia Sousa, Milene A. G. Fortunato, Joana Silva, Mónica Pingo, Alice Martins, Carlos A. M. Afonso, Rui Pedrosa, Filipa Siopa, Celso Alves
Publikováno v:
Marine Drugs, Vol 22, Iss 9, p 408 (2024)
Sphaerococcenol A is a cytotoxic bromoditerpene biosynthesized by the red alga Sphaerococcus coronopifolius. A series of its analogues (1–6) was designed and semi-synthesized using thiol-Michael additions and enone reduction, and the structures of
Externí odkaz:
https://doaj.org/article/8dff4be841094cd1ae26d0ba83fb6121
Autor:
Celso Martins, Diego O. Hartmann, Adélia Varela, Jaime A. S. Coelho, Pedro Lamosa, Carlos A. M. Afonso, Cristina Silva Pereira
Publikováno v:
Microbial Biotechnology, Vol 13, Iss 6, Pp 1983-1996 (2020)
Summary Hydroxymethylfurfural (HMF) is a promising lignocellulosic‐derived source for the generation of diverse chemical building blocks constituting an alternative to fossil fuels. However, it remains unanswered if ubiquitous fungi can ensure thei
Externí odkaz:
https://doaj.org/article/76a846a0980b49b2a1f66e590649d35c
Autor:
Stella Parmaki, Argyro Tsipa, Marlen I. Vasquez, João M. J. Gonçalves, Ioanna Hadjiadamou, Frederico C. Ferreira, Carlos A. M. Afonso, Chrysoulla Drouza, Michalis Koutinas
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-10 (2020)
Abstract Background Lupanine is a plant toxin contained in the wastewater of lupine bean processing industries, which could be used for semi-synthesis of various novel high added-value compounds. This paper introduces an environmental friendly proces
Externí odkaz:
https://doaj.org/article/2d6fd670770d468ab194ab4dfea0896f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3533 (2023)
In this work, the design and synthesis of a series of photochromic gemini diarylethene-based ionic liquids (GDILs) with different cationic motifs is reported. Several synthetic pathways were optimized for the formation of cationic GDILs with chloride
Externí odkaz:
https://doaj.org/article/6d16be8fb92f4b9dbf79128c380a0b94
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 97 (2022)
Nitrogen-containing heterocycles can have several applications in the pharmaceutical industry since they contain a wide spectrum of biological activities. Imidazolidinones have shown activity against leukemia, lung cancer, and metabolic disorders. Th
Externí odkaz:
https://doaj.org/article/ed79344bcecf4238b9fe6e5726cad86f
Autor:
Filipa Siopa, Raquel F. M. Frade, Ana Diniz, Joana M. Andrade, Marisa Nicolai, Ana Meirinhos, Susana D. Lucas, Filipa Marcelo, Carlos A. M. Afonso, Patrícia Rijo
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 17145-17154 (2018)
Externí odkaz:
https://doaj.org/article/2e72d255b9eb499c993fcadb5f2d07fa
Publikováno v:
Molbank, Vol 2021, Iss 2, p M1199 (2021)
Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-(
Externí odkaz:
https://doaj.org/article/5643f6f1217f48c2b605aa0a8fed27e9
Publikováno v:
Molecules, Vol 27, Iss 5, p 1673 (2022)
The presence of sulfur–carbon bonds is transversal to several areas of chemistry, e.g., drug discovery, materials, and chemical biology. However, a lack of efficient and sustainable procedures for the preparation of thioaminals, the N,S-analogues o
Externí odkaz:
https://doaj.org/article/e22e79b594924c8aa6e63752ca068501
Autor:
Catarina Garcia, Vera M. S. Isca, Filipe Pereira, Carlos M. Monteiro, Epole Ntungwe, Francisco Sousa, Jelena Dinic, Suvi Holmstedt, Amílcar Roberto, Ana Díaz-Lanza, Catarina P. Reis, Milica Pesic, Nuno R. Candeias, Ricardo J. Ferreira, Noélia Duarte, Carlos A. M. Afonso, Patrícia Rijo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Cancer is among the leading causes of death worldwide. One of the most challenging obstacles in cancer treatment is multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp) is associated with MDR. The growing incidence of cancer and the de
Externí odkaz:
https://doaj.org/article/e0c57d17a6814473b2b968463276ad86
Autor:
Sara R. Oliveira, Pedro A. Dionísio, Maria M. Gaspar, Maria B. T. Ferreira, Catarina A. B. Rodrigues, Rita G. Pereira, Mónica S. Estevão, Maria J. Perry, Rui Moreira, Carlos A. M. Afonso, Joana D. Amaral, Cecília M. P. Rodrigues
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5289 (2021)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (SN). Necroptosis is a caspase-indepe
Externí odkaz:
https://doaj.org/article/dfc4e03c53f9497a8575c4e31b255f03