Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Carlos A. Elena-Real"'
Autor:
Samuel Naudi-Fabra, Carlos A. Elena-Real, Ida Marie Vedel, Maud Tengo, Kathrin Motzny, Pin-Lian Jiang, Peter Schmieder, Fan Liu, Sigrid Milles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The early phases of clathrin mediated endocytosis are organized through a highly complex interaction network mediated by clathrin associated sorting proteins (CLASPs) that comprise long intrinsically disordered regions (IDRs). AP180 is a CLA
Externí odkaz:
https://doaj.org/article/0a7886336eb3462eb8da4dd6206dfce4
Autor:
Miguel Á. Casado-Combreras, Francisco Rivero-Rodríguez, Carlos A. Elena-Real, Dmitry Molodenskiy, Antonio Díaz-Quintana, Marlène Martinho, Guillaume Gerbaud, Katiuska González-Arzola, Adrián Velázquez-Campoy, Dmitri Svergun, Valérie Belle, Miguel A. De la Rosa, Irene Díaz-Moreno
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3695-3707 (2022)
Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ensemble of complexes, and the phenomenon is essential for the understanding of numerous biological processes. These conforma
Externí odkaz:
https://doaj.org/article/27f0f2e61f964aa7bcdbe731838c1382
Autor:
Anna Morató, Carlos A. Elena-Real, Matija Popovic, Aurélie Fournet, Karen Zhang, Frédéric Allemand, Nathalie Sibille, Annika Urbanek, Pau Bernadó
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1458 (2020)
The high-resolution structural study of huntingtin exon-1 (HttEx1) has long been hampered by its intrinsic properties. In addition to being prone to aggregate, HttEx1 contains low-complexity regions (LCRs) and is intrinsically disordered, ruling out
Externí odkaz:
https://doaj.org/article/d28061e9c75f424491a7f60eaa910fd2
Autor:
Carlos A. Elena-Real, Amin Sagar, Annika Urbanek, Matija Popovic, Anna Morató, Alejandro Estaña, Aurélie Fournet, Christine Doucet, Xamuel L. Lund, Zhen-Dan Shi, Luca Costa, Aurélien Thureau, Frédéric Allemand, Rolf E. Swenson, Pierre-Emmanuel Milhiet, Ramon Crehuet, Alessandro Barducci, Juan Cortés, Davy Sinnaeve, Nathalie Sibille, Pau Bernadó
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2023, 30 (3), pp.309-320. ⟨10.1038/s41594-023-00920-0⟩
Nature Structural and Molecular Biology, 2023, 30 (3), pp.309-320. ⟨10.1038/s41594-023-00920-0⟩
Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin (httex1). The structural changes occurring to the poly-Q when increa
Autor:
Carlos A. Elena-Real, Amin Sagar, Annika Urbanek, Matija Popovic, Anna Morató, Alejandro Estaña, Aurélie Fournet, Xamuel L. Lund, Zhen-Dan Shi, Luca Costa, Aurélien Thureau, Frédéric Allemand, Rolf E. Swenson, Pierre-Emmanuel Milhiet, Alessandro Barducci, Juan Cortés, Davy Sinnaeve, Nathalie Sibille, Pau Bernadó
Huntington’s Disease is a neurodegenerative disorder caused by a CAG expansion of the first exon of theHTTgene, resulting in an extended poly-glutamine (poly-Q) tract in the N-terminus of the protein huntingtin (httex1). The structural changes occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23483e7c4329f6acf67ec4472ca5d101
https://doi.org/10.1101/2022.10.25.513661
https://doi.org/10.1101/2022.10.25.513661
Publikováno v:
Bioinformatics
Bioinformatics, 2022, ⟨10.1093/bioinformatics/btac610⟩
Bioinformatics, 2022, 38 (21), pp.4851-4858. ⟨10.1093/bioinformatics/btac610⟩
Bioinformatics, 2022, ⟨10.1093/bioinformatics/btac610⟩
Bioinformatics, 2022, 38 (21), pp.4851-4858. ⟨10.1093/bioinformatics/btac610⟩
MotivationPoly-alanine (polyA) regions are protein stretches mostly composed of alanines. Despite their abundance in eukaryotic proteomes and their association to nine inherited human diseases, the structural and functional roles exerted by polyA str
Autor:
Katiuska González-Arzola, Antonio Díaz-Quintana, Noelia Bernardo-García, Jonathan Martínez-Fábregas, Francisco Rivero-Rodríguez, Miguel Á. Casado-Combreras, Carlos A. Elena-Real, Alejandro Velázquez-Cruz, Sergio Gil-Caballero, Adrián Velázquez-Campoy, Elzbieta Szulc, María P. Gavilán, Isabel Ayala, Rocío Arranz, Rosa M. Ríos, Xavier Salvatella, José M. Valpuesta, Juan A. Hermoso, Miguel A. De la Rosa, Irene Díaz-Moreno
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2022, 29 (10), pp.1024-1036. ⟨10.1038/s41594-022-00842-3⟩
Nature Structural and Molecular Biology, 2022, 29 (10), pp.1024-1036. ⟨10.1038/s41594-022-00842-3⟩
32 pags., 17 figs., 1 tab.
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet cytochrome c (Cc) migrates to the nucleus and even the nucleolus under stress conditions. Nucleolar li
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet cytochrome c (Cc) migrates to the nucleus and even the nucleolus under stress conditions. Nucleolar li
Autor:
Adrián Velázquez-Campoy, Irene Díaz-Moreno, Carlos A. Elena-Real, Antonio Díaz-Quintana, Crisanto Gutierrez, Miguel A. De la Rosa, Katiuska González-Arzola, Gonzalo Pérez-Mejías, Bénédicte Desvoyes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Universitat Politècnica de Catalunya (UPC)
instname
Universitat Politècnica de Catalunya (UPC)
12 pags., 6 figs.
Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the double role of extra‐mitochondrial cytochrome c in triggering apoptosis and inhibiting survival pathwa
Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the double role of extra‐mitochondrial cytochrome c in triggering apoptosis and inhibiting survival pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09274d5ea4e23ffa3f1d91dca17eb4cd
http://hdl.handle.net/10261/268444
http://hdl.handle.net/10261/268444
Autor:
Carlos A, Elena-Real, Katiuska, González-Arzola, Gonzalo, Pérez-Mejías, Antonio, Díaz-Quintana, Adrián, Velázquez-Campoy, Bénédicte, Desvoyes, Crisanto, Gutiérrez, Miguel A, De la Rosa, Irene, Díaz-Moreno
Publikováno v:
The Plant journal : for cell and molecular biologyREFERENCES. 106(1)
Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the double role of extra-mitochondrial cytochrome c in triggering apoptosis and inhibiting survival pathways is well reported. In p
Autor:
Karen Zhang, Aurélie Fournet, Frédéric Allemand, Carlos A. Elena-Real, Anna Morató, Matija Popovic, Pau Bernadó, Annika Urbanek, Nathalie Sibille
Publikováno v:
Biomolecules, Vol 10, Iss 1458, p 1458 (2020)
Biomolecules
Biomolecules, MDPI, 2020, 10 (10), pp.1458. ⟨10.3390/biom10101458⟩
Volume 10
Issue 10
Biomolecules
Biomolecules, MDPI, 2020, 10 (10), pp.1458. ⟨10.3390/biom10101458⟩
Volume 10
Issue 10
International audience; The high-resolution structural study of huntingtin exon-1 (HttEx1) has long been hampered by its intrinsic properties. In addition to being prone to aggregate, HttEx1 contains low-complexity regions (LCRs) and is intrinsically