Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Carlos Henrique Tomich de Paula da Silva"'
Autor:
Eliciane Cevolani Mattos, Lilian Pereira Silva, Clara Valero, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Liliane F. C. Ribeiro, Mark R. Marten, Rafael Silva-Rocha, Cauã Westmann, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft, Narjes Al-Furaiji, Michael Bromley, Uffe H. Mortensen, J. Philipp Benz, Neil Andrew Brown, Gustavo H. Goldman
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The mitogen-activated protein
Externí odkaz:
https://doaj.org/article/e4362aac315c465db4926930d9ce17bc
Publikováno v:
Eclética Química, Vol 33, Iss 4, Pp 13-23 (2018)
Molecular dynamics (MD) is a powerful computational tool used for rational drug design in medicinal chemistry. MD is an extension of Molecular Mechanics, where the dynamic behavior of a molecular system is simulated through numerical integration of t
Externí odkaz:
https://doaj.org/article/90f3cab8200e4a9b93d3bf77e472ca33
Autor:
Elenilson F da Silva, Krist Helen Antunes Fernandes, Denise Diedrich, Jessica Gotardi, Marcia Silvana Freire Franco, Carlos Henrique Tomich de Paula da Silva, Ana Paula Duarte de Souza, Simone Cristina Baggio Gnoatto
Publikováno v:
Beilstein Journal of Organic Chemistry. 18:1524-1531
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing a 1,2,4-triazole-3-carboxamide moiety, is a first-line drug for its treatment, however, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509b1fa7c8fa81998b2caed64ac23442
https://doi.org/10.3762/bjoc.18.161
https://doi.org/10.3762/bjoc.18.161
Autor:
Lorane Izabel da Silva Hage-Melim, Lenir Cabral Correia, Jaderson Vieira Ferreira, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft
Publikováno v:
Current Physical Chemistry. 12:243-256
Background: Alzheimer’s disease (AD) has been characterized by a progressive loss of cognitive functions, especially memory, impacting the daily life and personality of the elderly. In the present study, we performed molecular modeling of methylxan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d868a84565a38f8d0323437e65962ab3
https://doi.org/10.2174/1877946812666220913142810
https://doi.org/10.2174/1877946812666220913142810
Autor:
Lorane Izabel da Silva Hage-Melim, Daniel Castro da Costa, Hueldem Ronam Cristo Teixeira, Raí Campos Silva, Isaque Antonio Galindo Francischini, Carlos Henrique Tomich de Paula da Silva
Publikováno v:
Central Nervous System Agents in Medicinal Chemistry. 22:139-150
Background: Alzheimer's disease is a progressive neurodegenerative process with multifactorial characteristics. This disease follows the natural aging process, affecting mainly people over 65 years. Pharmacotherapeutic treatment currently combats sym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dba4b9e3c467dfee82e92cb274e114
https://doi.org/10.2174/1871524922666220517110606
https://doi.org/10.2174/1871524922666220517110606
Autor:
Suzane Quintana Gomes, Leonardo Bruno Federico, Guilherme Martins Silva, Carla Duque Lopes, Sérgio de Albuquerque, Carlos Henrique Tomich de Paula da Silva
Chagas disease is a well-known Neglected Tropical Disease, mostly endemic in continental Latin America, but that has spread to North America and Europe. Unfortunately, current treatments against such disease are ineffective and produce known and unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548032c619f373abb2e2dd9a3d70a532
Autor:
Ryan da Silva Ramos, Josivan da Silva Costa, Rai Campos Silva, Glauber Vilhena da Costa, Alex Bruno Lobato Rodrigues, Érica de Menezes Rabelo, Raimundo Nonato Picanço Souto, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silva, Joaquín Maria Campos Rosa, Cleydson Breno Rodrigues dos Santos, Williams Jorge da Cruz Macêdo
Publikováno v:
Pharmaceuticals, Vol 12, Iss 1, p 20 (2019)
Aedes aegypti is the main vector of dengue fever transmission, yellow fever, Zika, and chikungunya in tropical and subtropical regions and it is considered to cause health risks to millions of people in the world. In this study, we search to obtain n
Externí odkaz:
https://doaj.org/article/1535fe0d3e664806a963ef4ed543e2cd
Autor:
Karina R. da Silva, Jaderson Vieira Ferreira, Abraão Alves Pinheiro, Carlton A. Taft, Lorane Izabel da Silva Hage-Melim, Madson Ralide Fonseca Gomes, Maiara de Fátima de Brito Brito, Neuziane Dias Conceição, Lucilene R. de Souza, Carlos Henrique Tomich de Paula da Silva
Publikováno v:
Current Physical Chemistry. 11:4-17
Objectives: Carry out an in silico study of chemical substances isolated from the species: Drimys angustifolia and Drimys brasiliensis. Methods: A theoretical study of global reactivity, QSAR descriptors, MEP construction and molecular docking was pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e88800930ce46f983dcbb85fa933a5
https://doi.org/10.2174/1877946810666200124142439
https://doi.org/10.2174/1877946810666200124142439
Autor:
Leonardo B Federico, Amanda de Fraga Dias, Ana Maria Oliveira Battastini, Guilherme Martins Silva, Fabrício Figueiró, Luciano T. Costa, Joaquín Maria Carmpos Rosa, Cleydson B. R. Santos, Carlos Henrique Tomich de Paula da Silva
Publikováno v:
International Journal of Biological Macromolecules. 165:3040-3050
Among several strategies related to cancer therapy targeting the modulation of αβ-tubulin has shown encouraging findings, more specifically when this is achieved by inhibitors located at the colchicine binding site. In this work, we aim to fish new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b1b113da2c8d53a82106fcd44b069f
https://doi.org/10.1016/j.ijbiomac.2020.10.136
https://doi.org/10.1016/j.ijbiomac.2020.10.136
Autor:
Williams Jorge da Cruz Macêdo, Cleydson B. R. Santos, José M Espejo-Román, José Ciríaco Pinheiro, R Silva, Carlos Henrique Tomich de Paula da Silva, Franco Henrique Andrade Leite, E.B. Costa, M.F. de A. Neto, Jorddy Neves Cruz
Publikováno v:
SAR and QSAR in Environmental Research. 31:677-695
A set of 23 steroidal 1,2,4,5-tetraoxane analogues were studied using quantum-chemical method (B3LYP/6-31 G*) and multivariate analyses (PCA, HCA, KNN and SIMCA) in order to calculate the properties and correlate them with antimalarial activity (log
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70d79b05aee241b083a7afbbccf7d8f
https://doi.org/10.1080/1062936x.2020.1803961
https://doi.org/10.1080/1062936x.2020.1803961