Zobrazeno 1 - 10
of 875
pro vyhledávání: '"Carlos, Caldas"'
Autor:
Riccardo Masina, Carlos Caldas
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2065-2069 (2024)
Genomic medicine has transformed the lives of patients with cancer by enabling individualised and evidence‐based clinical decision‐making. Despite this progress, the implementation of precision cancer medicine is limited by its dependence on isol
Externí odkaz:
https://doaj.org/article/327f3120f96046ce894c1f6e0eae1265
Autor:
Shadi Basyuni, Laura Heskin, Andrea Degasperi, Daniella Black, Gene C. C. Koh, Lucia Chmelova, Giuseppe Rinaldi, Steven Bell, Louise Grybowicz, Greg Elgar, Yasin Memari, Pauline Robbe, Zoya Kingsbury, Carlos Caldas, Jean Abraham, Anna Schuh, Louise Jones, PARTNER Trial Group, Personalised Breast Cancer Program Group, Marc Tischkowitz, Matthew A. Brown, Helen R. Davies, Serena Nik-Zainal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Whole genome sequencing (WGS) provides comprehensive, individualised cancer genomic information. However, routine tumour biopsies are formalin-fixed and paraffin-embedded (FFPE), damaging DNA, historically limiting their use in WGS. Here we
Externí odkaz:
https://doaj.org/article/1788544aae364aa680930fe83e4b04ab
Autor:
Jia-Wern Pan, Zi-Ching Tan, Pei-Sze Ng, Muhammad Mamduh Ahmad Zabidi, Putri Nur Fatin, Jie-Ying Teo, Siti Norhidayu Hasan, Tania Islam, Li-Ying Teoh, Suniza Jamaris, Mee-Hoong See, Cheng-Har Yip, Pathmanathan Rajadurai, Lai-Meng Looi, Nur Aishah Mohd Taib, Oscar M. Rueda, Carlos Caldas, Suet-Feung Chin, Joanna Lim, Soo-Hwang Teo
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Triple-negative breast cancers (TNBCs) are a subset of breast cancers that have remained difficult to treat. A proportion of TNBCs arising in non-carriers of BRCA pathogenic variants have genomic features that are similar to BRCA carriers an
Externí odkaz:
https://doaj.org/article/d2857e682b734986b417f18c09ab31e4
Autor:
Cameron C. Young, Katherine Eason, Raquel Manzano Garcia, Richard Moulange, Sach Mukherjee, Suet-Feung Chin, Carlos Caldas, Oscar M. Rueda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract The Integrative Cluster subtypes (IntClusts) provide a framework for the classification of breast cancer tumors into 10 distinct groups based on copy number and gene expression, each with unique biological drivers of disease and clinical pro
Externí odkaz:
https://doaj.org/article/595a682d1e644b7d8c15b2e2fb169490
Autor:
Jia-Wern Pan, Mohana Ragu, Wei-Qin Chan, Siti Norhidayu Hasan, Tania Islam, Li-Ying Teoh, Suniza Jamaris, Mee-Hoong See, Cheng-Har Yip, Pathmanathan Rajadurai, Lai-Meng Looi, Nur Aishah Mohd Taib, Oscar M. Rueda, Carlos Caldas, Suet-Feung Chin, Joanna Lim, Soo-Hwang Teo
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Breast cancer exhibits significant heterogeneity, manifesting in various subtypes that are critical in guiding treatment decisions. This study aimed to investigate the existence of distinct subtypes of breast cancer within the Asian populati
Externí odkaz:
https://doaj.org/article/351360a830af473c9b955d098b6ff1fa
Autor:
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad A. Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc Van de Vijver, Steven Van Laere, Laura van’t Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke T. Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek D. Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, François Richard, Christine Desmedt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC di
Externí odkaz:
https://doaj.org/article/449fce543ad84736bc9d60953aa2df60
Publikováno v:
Project Leadership and Society, Vol 4, Iss , Pp 100092- (2023)
In early project phases, cross-functional collaboration is required to lead a capital project from an investment option to a full definition before its design and construction commenced. Given that many capital projects are large, complex, and take y
Externí odkaz:
https://doaj.org/article/23266aabf39c46b8b994e5e899fa740a
Autor:
Ian G. Cannell, Kirsty Sawicka, Isabella Pearsall, Sophia A. Wild, Lauren Deighton, Sarah M. Pearsall, Giulia Lerda, Fadwa Joud, Showkhin Khan, Alejandra Bruna, Kathryn L. Simpson, Claire M. Mulvey, Fiona Nugent, Fatime Qosaj, Dario Bressan, Caroline Dive, Carlos Caldas, Gregory J. Hannon
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112791- (2023)
Summary: Vasculogenic mimicry (VM) describes the formation of pseudo blood vessels constructed of tumor cells that have acquired endothelial-like properties. VM channels endow the tumor with a tumor-derived vascular system that directly connects to h
Externí odkaz:
https://doaj.org/article/f390fa24956d4ab7a84bdc36669be9b9
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Despite significant progress in breast cancer (BC) therapy, it is globally the most commonly diagnosed cancer and leads to the death of over 650,000 women annually. Androgen receptor (AR) is emerging as a potential new therapeutic target in
Externí odkaz:
https://doaj.org/article/940fa784f7c84843ac92d4cc00f2cffe
Autor:
Filipe Correia Martins, Dominique-Laurent Couturier, Ines de Santiago, Carolin Margarethe Sauer, Maria Vias, Mihaela Angelova, Deborah Sanders, Anna Piskorz, James Hall, Karen Hosking, Anumithra Amirthanayagam, Sabina Cosulich, Larissa Carnevalli, Barry Davies, Thomas B. K. Watkins, Ionut G. Funingana, Helen Bolton, Krishnayan Haldar, John Latimer, Peter Baldwin, Robin Crawford, Matthew Eldridge, Bristi Basu, Mercedes Jimenez-Linan, Andrew W. Mcpherson, Nicholas McGranahan, Kevin Litchfield, Sohrab P. Shah, Iain McNeish, Carlos Caldas, Gerard Evan, Charles Swanton, James D. Brenton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Chromosomal instability is a major challenge to patient stratification and targeted drug development for high-grade serous ovarian carcinoma. Here we show that identification of clonal somatic copy number alterations in frequently amplified cancer ge
Externí odkaz:
https://doaj.org/article/63184752d1ca4e718d39186ab46bf815