Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Carlos, Buesa"'
Autor:
Fernando Cavalcanti, Elena Gonzalez-Rey, Mario Delgado, Clara P. Falo, Leyre Mestre, Carmen Guaza, Francisco O’Valle, Michele M. P. Lufino, Jordi Xaus, Cristina Mascaró, Serena Lunardi, Natalia Sacilotto, Paola Dessanti, David Rotllant, Xavier Navarro, Mireia Herrando-Grabulosa, Carlos Buesa, Tamara Maes
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1420 (2022)
Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of
Externí odkaz:
https://doaj.org/article/df089ff6678843aa91f71f1d603fc7ce
Autor:
Tamara Maes, Cristina Mascaró, David Rotllant, Michele Matteo Pio Lufino, Angels Estiarte, Nathalie Guibourt, Fernando Cavalcanti, Christian Griñan-Ferré, Mercè Pallàs, Roser Nadal, Antonio Armario, Isidro Ferrer, Alberto Ortega, Nuria Valls, Matthew Fyfe, Marc Martinell, Julio César Castro Palomino, Carlos Buesa Arjol
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233468 (2020)
Transcription disequilibria are characteristic of many neurodegenerative diseases. The activity-evoked transcription of immediate early genes (IEGs), important for neuronal plasticity, memory and behavior, is altered in CNS diseases and governed by e
Externí odkaz:
https://doaj.org/article/f203ca35d63f4f55a0c4e2960580662d
Autor:
Olga Salamero, Tim C.P Somervaille, Antonieta Molero, Evelyn Acuña-Cruz, Jose A. Perez-Simon, Rosa Coll, Montserrat Arnan, Brayan Merchan, Ana Perez, Isabel Cano, Rebeca Rodríguez-Veiga, Mabel Arevalo, Sonia Gutierrez, Carlos Buesa, Douglas V Faller, Francesc Bosch, Pau Montesinos
Publikováno v:
Blood. 140:1711-1713
Autor:
Alberto Ortega, Tamara Maes, Alejandra Rodríguez-Gimeno, Natalia Sacilotto, Michele Matteo Pio Lufino, Cristina Mascaró, Robert Soliva, Carlos Buesa, Paola Dessanti, Jordi Salas
Publikováno v:
ACS Pharmacology & Translational Science. 4:1818-1834
Publikováno v:
Informe Gepec, Vol 21, Iss 1 (2017)
Há um debate considerável sobre a forma de como devem ser os métodos de ensino adaptados em uma sociedade que entra em sua quarta revolução industrial. Na área da formação a tecnologia é um aspecto a considerar ao projetar materiais educativ
Externí odkaz:
https://doaj.org/article/04c96fe65464456684db27c7b7e84f05
Autor:
Juan Manuel Ferrero-Cafiero, Rosa M. Antonijoan, Cesar Molinero, Tamara Maes, Maria Isabel Arevalo, Montse Puntes, Cristina Mascaró, Jimena Coimbra, Joan Martínez-Colomer, Carlos Buesa
Publikováno v:
CNS Drugs
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
CNS DRUGS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
CNS DRUGS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Background Vafidemstat, an inhibitor of the histone lysine-specific demethylase KDM1A, corrects cognition deficits and behavior alterations in rodent models. Here, we report the results from the first-in-human trial of vafidemstat in healthy young an
Autor:
Natalia, Sacilotto, Paola, Dessanti, Michele M P, Lufino, Alberto, Ortega, Alejandra, Rodríguez-Gimeno, Jordi, Salas, Tamara, Maes, Carlos, Buesa, Cristina, Mascaró, Robert, Soliva
Publikováno v:
ACS pharmacologytranslational science. 4(6)
Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates. In addition to its enzymati
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 265-273 (2006)
Parkinson disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein and ubiquitin in protein aggregates conforming Lewy bodies and Lewy neurites. Ubiquitin C-terminal hydrolase-1 (UCHL-1) disassem
Externí odkaz:
https://doaj.org/article/173e45ca6321487eb519d74dd94e841f
Autor:
Michele M.P. Lufino, Serena Lunardi, Natalia Sacilotto, Tamara Maes, Mireia Herrando-Grabulosa, David Rotllant, Carlos Buesa, Jordi Xaus, Paola Dessanti, Carmen Guaza, Xavier Navarro, Elena Gonzalez-Rey, Cristina Mascaró, Mario Delgado, F. L. Cavalcanti, Leyre Mestre
Background Vafidemstat (ORY-2001) is a clinical stage inhibitor of the Lysine Specific Demethylase KDM1A in development for treatment of neurodegenerative and psychiatric diseases. KDM1A demethylates H3K4me1/2 and together with the histone deacetylas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc502a6fe4bd89e62039ecf96871e3e
https://doi.org/10.21203/rs.3.rs-114482/v4
https://doi.org/10.21203/rs.3.rs-114482/v4
Publikováno v:
Alzheimer's & Dementia. 16