Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity.

Autor: Guilherme D Brand, Marcelo H S Ramada, Júlia R Manickchand, Rafael Correa, Dalila J S Ribeiro, Michele A Santos, Andreanne G Vasconcelos, Fernando Y Abrão, Maura V Prates, André M Murad, José L Cardozo Fh, José Roberto S A Leite, Kelly G Magalhães, Aline L Oliveira, Carlos Bloch

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0220656 (2019)

Following the treads of our previous works on the unveiling of bioactive peptides encrypted in plant proteins from diverse species, the present manuscript reports the occurrence of four proof-of-concept intragenic antimicrobial peptides in human prot

Externí odkaz: https://doaj.org/article/64549cad81a847689e2af27defd9c68c

Release of immunomodulatory peptides at bacterial membrane interfaces as a novel strategy to fight microorganisms

Autor: Thiago Viana de Freitas, Utsa Karmakar, Andreanne G. Vasconcelos, Michele A. Santos, Bianca Oliveira do Vale Lira, Samuel Ribeiro Costa, Eder Alves Barbosa, José Cardozo-Fh, Rafael Correa, Dalila J.S. Ribeiro, Maura Vianna Prates, Kelly G. Magalhães, Marcelo Henrique Soller Ramada, José Roberto de Souza Almeida Leite, Carlos Bloch, Aline Lima de Oliveira, Marc Vendrell, Guilherme Dotto Brand

Publikováno v: Viana de freitas, T, Karmakar, U, Vasconcelos, A, Santos, M, Oliveira do vale lira, B, Costa, S, Barbosa, E, Cardozo-Fh, J, Correa, R, Ribeiro, D S, Prates, M, Magalhães, K, Soller ramada, M, Roberto de souza almeida leite, J, Bloch, C, Lima de oliveira, A, Vendrell, M & Brand, G 2023, ' Release of immunomodulatory peptides at bacterial membrane interfaces as a novel strategy to fight microorganisms ', Journal of Biological Chemistry, vol. 299, no. 4, 103056, pp. 103056 . https://doi.org/10.1016/j.jbc.2023.103056
J Biol Chem

Cationic and amphiphilic peptides can be used as homing devices to accumulate conjugated antibiotics to bacteria-enriched sites and promote efficient microbial killing. However, just as important as tackling bacterial infections, is the modulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7735476505ebb74413df457e6398e567
https://www.pure.ed.ac.uk/ws/files/332308457/PIIS0021925823001886_3_.pdf

A Linear 19-Mer Plant Defensin-Derived Peptide Acts Synergistically with Caspofungin against Candida albicans Biofilms

Autor: Tanne L. Cools, Caroline Struyfs, Jan W. Drijfhout, Soňa Kucharíková, Celia Lobo Romero, Patrick Van Dijck, Marcelo H. S. Ramada, Carlos Bloch, Bruno P. A. Cammue, Karin Thevissen

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is

Externí odkaz: https://doaj.org/article/a3d63a73aff04935be804b82997406db

Probing human proteins for short encrypted antimicrobial peptides reveals Hs10, a peptide with selective activity for gram-negative bacteria

Autor: Michele A. Santos, Fernanda L. Silva, Bianca O.V. Lira, José L. Cardozo Fh, Andreanne G. Vasconcelos, Alyne R. Araujo, André M. Murad, Aisel V. Garay, Sonia M. Freitas, José Roberto S.A. Leite, Carlos Bloch, Marcelo H.S. Ramada, Aline Lima de Oliveira, Guilherme D. Brand

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1867:130265

Some cationic and amphiphilic α-helical segments of proteins adsorb to prokaryotic membranes when synthesized as individual polypeptide sequences, resulting in broad and potent antimicrobial activity. However, amphiphilicity, a determinant physicoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d62df53d8922d7eb55737076613b3e
https://doi.org/10.1016/j.bbagen.2022.130265

Phylloseptin-1 is Leishmanicidal for Amastigotes of Leishmania amazonensis Inside Infected Macrophages

Autor: Gustavo Adolfo Sierra Romero, Tatiana Karla dos Santos Borges, José Roberto S. A. Leite, Luciana M. Leite, Daniel C. Moreira, Selma A S Kuckelhaus, Maura V. Prates, Daniela Sant’Ana de Aquino, Carlos S. Kückelhaus, Maria Imaculada Muniz-Junqueira, Carlos Bloch

Publikováno v: International Journal of Environmental Research and Public Health, Vol 17, Iss 4856, p 4856 (2020)
International Journal of Environmental Research and Public Health
Volume 17
Issue 13
Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA

Leishmania protozoans are the causal agents of neglected diseases that represent an important public health issue worldwide. The growing occurrence of drug-resistant strains of Leishmania and severe side effects of available treatments represent an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f779a3570603845395a593c0d7354366
https://www.mdpi.com/1660-4601/17/13/4856