Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Carlo Sensenhauser"'
Autor:
Shannon Dallas, Thomas Wilde, Avijit Ghosh, Jianyao Wang, Yawei Dong, Gaochao Tian, Daohong Liao, Xueliang Li, Lawrence Szewczuk, Peter King, David C. Evans, Yifan Shi, Kurtis E. Bachman, Javier Suarez, Beth Pietrak, James P. Edwards, Carlo Sensenhauser, Hao Chen, Vineet Pande, Peter J. Connolly, Karen DiLoreto, William G Bonnette, Shefali Patel, Zhuming Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:11570-11596
Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of
Publikováno v:
Drug Metabolism and Disposition. 47:9-14
Imetelstat, a 13-base oligonucleotide (5'-TAGGGTTAGACAA-3'), is a potent, investigational telomerase inhibitor in clinical development for the treatment of hematologic myeloid malignancies. Modifications to imetelstat oligonucleotide chemistry includ
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:15-27
Domperidone is a dopamine receptor antagonist and a substrate of CYP3A4, hence there is a potential for CYP3A inhibition-based drug-drug interactions (DDI). A physiologically based pharmacokinetic model was developed to describe DDIs between domperid
Autor:
Shannon Dallas, Jose Silva, Xin Hong, Yinghua Qu, Rashidah Binte Sakban, N. Singh, Carlo Sensenhauser, Sylvia Zhao, Heng-Keang Lim, Hanry Yu, Michael McMillian, Lei Xia
Publikováno v:
Journal of Applied Toxicology. 36:320-329
Cytochrome P450 (CYP) induction is a key risk factor of clinical drug-drug interactions that has to be mitigated in the early phases of drug discovery. Three-dimensional (3D) cultures of hepatocytes in vitro have recently emerged as a potentially bet
Autor:
Jan Snoeys, Ellen Scheers, David C. Evans, Carlo Sensenhauser, Heng-Keang Lim, Laurent Leclercq, Peter Verboven, Shannon Dallas, Michael F. Kelley, Mark D. Johnson, Filip Cuyckens, Rao N.V.S. Mamidi
Aims Canagliflozin is a recently approved drug for use in the treatment of type 2 diabetes. The potential for canagliflozin to cause clinical drug-drug interactions (DDIs) was assessed. Methods DDI potential of canagliflozin was investigated using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2c9abf5fb872c233c8c45485ac3e9b
https://europepmc.org/articles/PMC5401984/
https://europepmc.org/articles/PMC5401984/
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S52
Autor:
Johan Monbaliu, James Jiao, Caly Chien, Hans Stieltjes, Johan W. Smit, Inneke Wynant, Martha Gonzalez, Carlo Sensenhauser, Jan Snoeys, Apexa Bernard
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(10)
Abiraterone acetate, the prodrug of the cytochrome P450 C17 inhibitor abiraterone, plus prednisone is approved for treatment of metastatic castration-resistant prostate cancer. We explored whether abiraterone interacts with drugs metabolized by CYP2C
Autor:
Cindy Zakszewski, Rao N.V.S. Mamidi, Michael McMillia, Chao Han, Monica Singer, Carlo Sensenhauser, Shannon Dallas, Ameesha Batheja, Honghui Zhou, Jose Silva, Maria Markowska
Publikováno v:
Current Drug Metabolism. 13:923-929
Inflammatory diseases such as rheumatoid arthritis and psoriasis are characterized by increases in circulating cytokines, which play an important role in modulation of the disease state. Several marketed bio-therapeutics target cytokines and act as e
Autor:
Jose Silva, Heng-Keang Lim, Vedwatee Gopaul, Tynisha Thomas, Rhys Salter, Paul F. Jackson, Kevin Cook, Kenneth J. Rhodes, Carlo Sensenhauser, Stefanie Rassnick, David C. Evans, Chen Jie, Robert Preston, Brian C. Shook
Publikováno v:
Chemical Research in Toxicology. 24:1012-1030
2-Amino-4-phenyl-8-pyrrolidin-1-ylmethyl-indeno[1,2-d]pyrimidin-5-one (1) is a novel and potent selective dual A(2A)/A(1) adenosine receptor antagonist from the arylindenopyrimidine series that was determined to be genotoxic in both the Ames and Mous
Publikováno v:
Rapid Communications in Mass Spectrometry. 22:1295-1311
A need still exists for a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method that can detect broad classes of glutathione (GSH) conjugates and provide characterization of their structures. We now describe the development of a method tha