Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Carlo Santambrogio"'
Autor:
Giulia Tomaino, Camilla Pantaleoni, Annalisa D’Urzo, Carlo Santambrogio, Filippo Testa, Matilde Ciprandi, Davide Cotugno, Gianni Frascotti, Marco Vanoni, Paolo Tortora
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6629 (2024)
Vaults are eukaryotic ribonucleoproteins consisting of 78 copies of the major vault protein (MVP), which assemble into a nanoparticle with an about 60 nm volume-based size, enclosing other proteins and RNAs. Regardless of their physiological role(s),
Externí odkaz:
https://doaj.org/article/dd830891f6234f00a1e9aab9e41d6ef3
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 10, p 266 (2023)
Dopaminergic neurons are constantly threatened by the thin boundaries between functional α-synuclein (AS) structural disorder and pathogenic aggregation, and between dopamine (DA) neurotransmitter activity and accumulation of cytotoxic by-products.
Externí odkaz:
https://doaj.org/article/b4157a8772d44a5c833016ca3d9ab6ea
Autor:
Erika Ponzini, Silvia Tavazzi, Giacomo Musile, Franco Tagliaro, Rita Grandori, Carlo Santambrogio
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2188 (2022)
The tear film is a complex matrix composed of several molecular classes, from small metal ions to macromolecules. Contact lens (CL) wear can affect the protein homeostasis of the tear film, by accumulating deposits on the CL surface and/or altering t
Externí odkaz:
https://doaj.org/article/e289160ab6a84775ab0724bbaf24cb3b
Autor:
Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 561 (2022)
Intrinsically disordered proteins (IDPs) are ensembles of interconverting conformers whose conformational properties are governed by several physico-chemical factors, including their amino acid composition and the arrangement of oppositely charged re
Externí odkaz:
https://doaj.org/article/74a6d0439ad1402bb57c97fb37f25c7e
Autor:
Erika Ponzini, Diletta Ami, Alessandro Duse, Carlo Santambrogio, Antonella De Palma, Dario Di Silvestre, Pierluigi Mauri, Fabio Pezzoli, Antonino Natalello, Silvia Tavazzi, Rita Grandori
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10750 (2021)
Lacrimal fluid is an attractive source of noninvasive biomarkers, the main limitation being the small sample amounts typically collected. Advanced analytical methods to allow for proteomics profiling from a few microliters are needed to develop innov
Externí odkaz:
https://doaj.org/article/5aa506c4482b4054974e42d5768430bc
Autor:
Arianna Luise, Elena De Cecco, Erika Ponzini, Martina Sollazzo, PierLuigi Mauri, Frank Sobott, Giuseppe Legname, Rita Grandori, Carlo Santambrogio
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 893 (2021)
The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiologica
Externí odkaz:
https://doaj.org/article/41e57b59baec43a3988a20f7e2618f03
Autor:
Anita Carija, Francisca Pinheiro, Jordi Pujols, Inês C. Brás, Diana Fernandes Lázaro, Carlo Santambrogio, Rita Grandori, Tiago F. Outeiro, Susanna Navarro, Salvador Ventura
Publikováno v:
Redox Biology, Vol 22, Iss , Pp - (2019)
The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated
Externí odkaz:
https://doaj.org/article/1de474bdc01e470880d6ec847b05a0c5
Autor:
Cristina Visentin, Luca Broggini, Benedetta Maria Sala, Rosaria Russo, Alberto Barbiroli, Carlo Santambrogio, Simona Nonnis, Anatoly Dubnovitsky, Martino Bolognesi, Elena Miranda, Adnane Achour, Stefano Ricagno
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3235 (2020)
Neuroserpin (NS) is a member of the serine protease inhibitors superfamily. Specific point mutations are responsible for its accumulation in the endoplasmic reticulum of neurons that leads to a pathological condition named familial encephalopathy wit
Externí odkaz:
https://doaj.org/article/b4f1f4887daf4073bafdfe98de5943d7
Autor:
Roberta Corti, Claudia A. Marrano, Domenico Salerno, Stefania Brocca, Antonino Natalello, Carlo Santambrogio, Giuseppe Legname, Francesco Mantegazza, Rita Grandori, Valeria Cassina
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5181 (2019)
Description of heterogeneous molecular ensembles, such as intrinsically disordered proteins, represents a challenge in structural biology and an urgent question posed by biochemistry to interpret many physiologically important, regulatory mechanisms.
Externí odkaz:
https://doaj.org/article/bb8b51ebef624fe6ae4fd01bb7cf00fa
Autor:
Anna Russo, Pasqualina Liana Scognamiglio, Rolando Pablo Hong Enriquez, Carlo Santambrogio, Rita Grandori, Daniela Marasco, Antonio Giordano, Giacinto Scoles, Sara Fortuna
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165349 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0133571.].
Externí odkaz:
https://doaj.org/article/a3ec5b750ff54f349db6541bbf9ed22b