Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Carlo Sala"'
Autor:
Rikesh M Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S Harris, Orjona S Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S H Danial, Matthew Swire, Marcus Lloyd, Tatiana A Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002727 (2024)
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are the main source of pathogenic Aβ is untested. Here, we challenge this prevailing belief by demonstrat
Externí odkaz:
https://doaj.org/article/2e71a01aa3f9400c837e535979db6d83
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract We study the role of contingent convertible bonds (CoCos) in a complex network of interconnected banks. By studying the system’s phase transitions, we reveal that the structure of the interbank network is of fundamental importance for the
Externí odkaz:
https://doaj.org/article/c0dc16a1434348e3a094315983dd297c
Autor:
Jessica Pagano, Silvia Landi, Alessia Stefanoni, Gabriele Nardi, Marica Albanesi, Helen F. Bauer, Enrico Pracucci, Michael Schön, Gian Michele Ratto, Tobias M. Boeckers, Carlo Sala, Chiara Verpelli
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Background Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and autistic-like behaviors and is primarily caused by haploinsufficiency of SHANK3 gene. Currently,
Externí odkaz:
https://doaj.org/article/cabd6c068e5d4c2c8d133798df3ee23c
Autor:
Stefania Beretta, Laura Gritti, Luisa Ponzoni, Paolo Scalmani, Massimo Mantegazza, Mariaelvina Sala, Chiara Verpelli, Carlo Sala
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-22 (2022)
Abstract Background Dravet Syndrome is a severe childhood pharmaco-resistant epileptic disorder mainly caused by mutations in the SCN1A gene, which encodes for the α1 subunit of the type I voltage-gated sodium channel (NaV1.1), that causes imbalance
Externí odkaz:
https://doaj.org/article/2d0036ea25774692aeaf9f3bcfa30cad
Autor:
Katy Phelan, Luigi Boccuto, Craig M. Powell, Tobias M. Boeckers, Conny van Ravenswaaij-Arts, R. Curtis Rogers, Carlo Sala, Chiara Verpelli, Audrey Thurm, William E. Bennett, Christopher J. Winrow, Sheldon R. Garrison, Roberto Toro, Thomas Bourgeron
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-4 (2022)
Abstract Phelan-McDermid syndrome (PMS) was initially called the 22q13 deletion syndrome based on its etiology as a deletion of the distal long arm of chromosome 22. These included terminal and interstitial deletions, as well as other structural rear
Externí odkaz:
https://doaj.org/article/399efd35b13d49aca4c80ce2e31e1dfa
Autor:
Francesco Trovato, Riccardo Parra, Enrico Pracucci, Silvia Landi, Olga Cozzolino, Gabriele Nardi, Federica Cruciani, Vinoshene Pillai, Laura Mosti, Andrzej W. Cwetsch, Laura Cancedda, Laura Gritti, Carlo Sala, Chiara Verpelli, Andrea Maset, Claudia Lodovichi, Gian Michele Ratto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Genetic mosaicism is frequently present in monogenic diseases of the central nervous system. Here the authors design a dual-colour reporter system that can be used to tune the degree of mosaicism in mouse models.
Externí odkaz:
https://doaj.org/article/1c4e916eb6864c37acafbefd423dd53f
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Externí odkaz:
https://doaj.org/article/61861fefd64d43b88b472a506d41981c
Autor:
Matteo Marcatili, Carlo Sala, Antonios Dakanalis, Fabrizia Colmegna, Armando D’Agostino, Orsola Gambini, Bernardo Dell’Osso, Beatrice Benatti, Luciano Conti, Massimo Clerici
Publikováno v:
Therapeutic Advances in Psychopharmacology, Vol 10 (2020)
Approximately 30% of Major Depressive Disorder (MDD) patients develop treatment-resistant depression (TRD). Among the different causes that make TRD so challenging in both clinical and research contexts, major roles are played by the inadequate under
Externí odkaz:
https://doaj.org/article/5c66001891c54713b1ed607ae3e3e979
Autor:
Ilaria Ferrari, Chiara Verpelli, Arianna Crespi, Carlo Sala, Diego Fornasari, Grazia Pietrini
Publikováno v:
Communicative & Integrative Biology, Vol 11, Iss 3, Pp 1-7 (2018)
We here investigated the effects of overexpressed superoxide dismutase (SOD)1 and amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants G93A and G147S in Neuro 2A (N2A) cell lines, and found a three-fold increase in lamellipodia either in cells cul
Externí odkaz:
https://doaj.org/article/1fe0291991664da3922fcd7716b4b1f8
Autor:
Jonathan Zapata, Edoardo Moretto, Saad Hannan, Luca Murru, Anna Longatti, Davide Mazza, Lorena Benedetti, Matteo Fossati, Christopher Heise, Luisa Ponzoni, Pamela Valnegri, Daniela Braida, Mariaelvina Sala, Maura Francolini, Jeffrey Hildebrand, Vera Kalscheuer, Francesca Fanelli, Carlo Sala, Bernhard Bettler, Silvia Bassani, Trevor G. Smart, Maria Passafaro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiet
Externí odkaz:
https://doaj.org/article/4624279b47d64159ad6a26ab96fc80e0