Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Carlo Rinaldi"'
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110373- (2024)
Summary: Homologous recombination is initiated by the nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process. In the short-range step, the MRX (Mre11-Rad50-Xrs2) complex, together with Sae2, incise
Externí odkaz:
https://doaj.org/article/005a8cfcaad84c2196cb2a5f63050469
Autor:
Anna J Kordala, Jessica Stoodley, Nina Ahlskog, Muhammad Hanifi, Antonio Garcia Guerra, Amarjit Bhomra, Wooi Fang Lim, Lyndsay M Murray, Kevin Talbot, Suzan M Hammond, Matthew JA Wood, Carlo Rinaldi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The advent of approved treatments for this devastating condition has significantly changed SMA patients' life expectancy and quality of life. Nevertheless, these a
Externí odkaz:
https://doaj.org/article/0a6be327d14849d1ae2a1fc49bf73886
Autor:
Erika Casari, Paolo Pizzul, Carlo Rinaldi, Marco Gnugnoli, Michela Clerici, Maria Pia Longhese
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113360- (2023)
Summary: DNA damage elicits a checkpoint response depending on the Mec1/ATR kinase, which detects the presence of single-stranded DNA and activates the effector kinase Rad53/CHK2. In Saccharomyces cerevisiae, one of the signaling circuits leading to
Externí odkaz:
https://doaj.org/article/e5a235e7d82741c1906f75bd2f41209b
Autor:
Ramachandran Prakasam, Angela Bonadiman, Roberta Andreotti, Emanuela Zuccaro, Davide Dalfovo, Caterina Marchioretti, Debasmita Tripathy, Gianluca Petris, Eric N. Anderson, Alice Migazzi, Laura Tosatto, Anna Cereseto, Elena Battaglioli, Gianni Sorarù, Wooi Fang Lim, Carlo Rinaldi, Fabio Sambataro, Naemeh Pourshafie, Christopher Grunseich, Alessandro Romanel, Udai Bhan Pandey, Andrea Contestabile, Giuseppe Ronzitti, Manuela Basso, Maria Pennuto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Here, Prakasam and colleagues show that polyQ-expanded androgen receptor toxicity can be attenuated using artificial miRNAs targeting Lsd1 and Prmt6, two AR-co-activators overexpressed in an androgen-dependent manner specifically in skeletal muscle,
Externí odkaz:
https://doaj.org/article/9fd52a5a537f405caa90331491bb84a3
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies. One of the main triggers of replicative senescence is telomere sho
Externí odkaz:
https://doaj.org/article/2ff000631ee54863b1077de7d7a55039
Autor:
Paolo Pizzul, Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Flavio Corallo, Maria Pia Longhese
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Studies performed in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have led the way in defining the DNA damage checkpoint and in identifying most of the proteins involved in this regulatory network, which turned out to have struct
Externí odkaz:
https://doaj.org/article/5f64489a026446b5874afaa79be51d82
Autor:
Audrey M. Winkelsas, Christopher Grunseich, George G. Harmison, Katarzyna Chwalenia, Carlo Rinaldi, Suzan M. Hammond, Kory Johnson, Melissa Bowerman, Sukrat Arya, Kevin Talbot, Matthew J. Wood, Kenneth H. Fischbeck
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 731-742 (2021)
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. All patients have at least one copy of a paralog, SMN2, but a C-to-T transition in this gene results in exon 7 skipping in a maj
Externí odkaz:
https://doaj.org/article/d9d006289a604f67a876744aeacd1ddf
Autor:
Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Paolo Pizzul, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Publikováno v:
Cells, Vol 11, Iss 20, p 3224 (2022)
Early work by Muller and McClintock discovered that the physical ends of linear chromosomes, named telomeres, possess an inherent ability to escape unwarranted fusions. Since then, extensive research has shown that this special feature relies on spec
Externí odkaz:
https://doaj.org/article/79fd461168b14762b39a5c02ee1060b7
Publikováno v:
IJU Case Reports, Vol 5, Iss 4, Pp 254-254 (2022)
Externí odkaz:
https://doaj.org/article/5ea525926045415b9219d45a5612462b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the nascent RNA strongly binds the template DNA strand, l
Externí odkaz:
https://doaj.org/article/69ad709bd68c4433b77b95de79917b07