Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carlo Giorgio Barracchia"'
Autor:
Carlo Giorgio Barracchia, Roberto Tira, Francesca Parolini, Francesca Munari, Luigi Bubacco, Georgios A. Spyroulias, Mariapina D’Onofrio, Michael Assfalg
Publikováno v:
Molecules, Vol 25, Iss 11, p 2716 (2020)
Background: The intrinsically disordered, amyloidogenic protein Tau associates with diverse classes of molecules, including proteins, nucleic acids, and lipids. Mounting evidence suggests that fatty acid molecules could play a role in the dysfunction
Externí odkaz:
https://doaj.org/article/42e1df25def4428b8a27111e6a65d7aa
Autor:
Carlo Giorgio Barracchia, Francesca Parolini, Angela Volpe, Daniele Gori, Francesca Munari, Stefano Capaldi, Mariapina D’Onofrio, Michael Assfalg
Publikováno v:
Bioconjugate chemistry. 33(7)
Intrinsically disordered proteins (IDPs) are increasingly found to be associated with irreversible neurodegenerative disorders. The protein tau is a prototypical IDP whose abnormal aggregation into insoluble filaments is a major hallmark of Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63cf20c15617568b2c11c9d83f30822
https://pubmed.ncbi.nlm.nih.gov/35686491
https://pubmed.ncbi.nlm.nih.gov/35686491
Autor:
Carlo Giorgio Barracchia, Giuseppe Legname, Michael Assfalg, Rita Grandori, Alessandro Romeo, Roberto Tira, Francesca Munari, Davide Prosperi, Carlo Santambrogio, Elena De Cecco, Valentina Rigamonti
Publikováno v:
International Journal of Biological Macromolecules. 154:206-216
The notion that nanoscale surfaces influence protein conformational transitions stimulates the investigation of fibrillogenic polypeptides adsorbing to nanomaterials. Alpha-synuclein (αS) is a prototypical amyloidogenic protein whose aggregation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd908576201c236f5ea68a316f6259d9
https://doi.org/10.1016/j.ijbiomac.2020.03.118
https://doi.org/10.1016/j.ijbiomac.2020.03.118
Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias
Autor:
Giuditta Dal Cortivo, Carlo Giorgio Barracchia, Valerio Marino, Mariapina D’Onofrio, Daniele Dell’Orco
Calmodulin (CaM), a ubiquitous and highly conserved Ca2+-sensor protein involved in the regulation of over 300 molecular targets, has been recently associated with severe forms of lethal arrhythmia. Here, we investigated how arrhythmia-associated mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ea08d76e191b6fe41df8044bc883fd
http://hdl.handle.net/11562/1057623
http://hdl.handle.net/11562/1057623
Autor:
Giovanna Viola, Carlo Giorgio Barracchia, Roberto Tira, Francesca Parolini, Giulia Leo, Massimo Bellanda, Francesca Munari, Stefano Capaldi, Mariapina D’Onofrio, Michael Assfalg
Understanding the interactions between nanoparticles (NPs) and proteins is crucial for the successful application of NPs in biological contexts. Protein adsorption is dependent on particle size, and protein binding to ultrasmall (1-3 nm) NPs is consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3313a0de7b831443144ce51f25a5738b
https://hdl.handle.net/11562/1077886
https://hdl.handle.net/11562/1077886
Autor:
Francesca Parolini, Roberto Tira, Carlo Giorgio Barracchia, Francesca Munari, Stefano Capaldi, Mariapina D'Onofrio, Michael Assfalg
The formation of biomolecular condensates has emerged as a crucial player both in neuronal physiology and neurodegeneration. Phase separation of the Alzheimer's related protein tau into liquid condensates is facilitated by polyanions and is regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ca7c5597522b86daa019a71db973e0
http://hdl.handle.net/11562/1059160
http://hdl.handle.net/11562/1059160
Autor:
Luigi Bubacco, Francesca Munari, Michael Assfalg, Mariapina D'Onofrio, Carlo Giorgio Barracchia, Francesca Parolini, Roberto Tira
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4400, p 4400 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4400, p 4400 (2020)
Ubiquitin, a protein modifier that regulates diverse essential cellular processes, is also a component of the protein inclusions characteristic of many neurodegenerative disorders. In Alzheimer&rsquo
s disease, the microtubule associated tau pro
s disease, the microtubule associated tau pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa5f3c9339c9a7f25521cec9e1f93b2
Autor:
Giorgio Arrigoni, Michael Assfalg, Alessandro Romeo, Francesca Parolini, Mariapina D'Onofrio, Cinzia Franchin, Carlo Giorgio Barracchia, Francesca Munari, Luigi Bubacco, Stefano Capaldi
Publikováno v:
Angewandte Chemie (International ed. in English). 59(16)
In the brain of individuals with Alzheimer's disease, the regulatory protein ubiquitin is found conjugated to different lysine residues of tau protein assembled into pathological paired helical filaments. To shed light on the hitherto unexplored ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e177d9d9a26284240e33ba2964f5f0
https://pubmed.ncbi.nlm.nih.gov/32022419
https://pubmed.ncbi.nlm.nih.gov/32022419
Autor:
Michael Assfalg, Mariapina D'Onofrio, Serena Zanzoni, Francesca Munari, Carlo Giorgio Barracchia, Andrea Bortot
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1865(9)
Liver fatty acid binding protein (L-FABP) is an abundant cytosolic protein playing a central role in intracellular lipid trafficking. The L-FABP T94A variant, originating from one of the most common polymorphisms in the FABP family, is associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118cefd0a6697d23f2a4545dfd782428
https://pubmed.ncbi.nlm.nih.gov/28668637
https://pubmed.ncbi.nlm.nih.gov/28668637