Autophagy is Activated In Vivo during Trimethyltin-Induced Apoptotic Neurodegeneration: A Study in the Rat Hippocampus

Autor: Aurora Del Fa, Ornella Parolini, Carlo Gangitano, Sabrina Ceccariglia, Fabrizio Michetti, Alessandra Alvino

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 1
International Journal of Molecular Sciences, Vol 21, Iss 1, p 175 (2019)

Trimethyltin (TMT) is an organotin compound known to produce significant and selective neuronal degeneration and reactive astrogliosis in the rodent central nervous system. Autophagy is the main cellular mechanism for degrading and recycling protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277b7fc6a9c971ea9a002aade69c16db

Increased expression of Aquaporin 4 in the rat hippocampus and cortex during trimethyltin-induced neurodegeneration

Autor: Marta Barba, Andrea Silvestrini, Sabrina Ceccariglia, A. Del Fa, Carlo Gangitano, Anna D'Altocolle, Fabrizio Pizzolante, Fabrizio Michetti, Andrea Repele

Publikováno v: Neuroscience. 274:273-288

Trimethyltin chloride (TMT) is a neurotoxicant producing neuronal degeneration and reactive astrogliosis in the mammalian central nervous system, especially the hippocampus. A previous magnetic resonance imaging investigation in TMT-treated rats evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac466269f5dbbb64b5071ba50c74d0c
https://doi.org/10.1016/j.neuroscience.2014.05.047

Expression of the neurokinin 1 receptor in the mouse retina

Autor: Luigi Bosco, Carlo Gangitano, Elisabetta Catalani, Giovanni Casini

Publikováno v: Neuroscience. 128:519-530

Previous studies have revealed that the expression pattern of the neurokinin 1 receptor (the preferred receptor for substance P, SP) varies in different mammalian retinas. We investigated NK1 receptor expression in the mouse retina to provide backgro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42b1c95c601912a88dbc2a41246f3a8
https://doi.org/10.1016/j.neuroscience.2004.07.004

Cathepsin D plays a crucial role in the trimethyltin-induced hippocampal neurodegeneration process

Autor: F. Pizzolante, A. Del Fa, Carlo Gangitano, Fabrizio Michetti, Anna D'Altocolle, Sabrina Ceccariglia, E. Caccia

Publikováno v: Neuroscience. 174

Trimethyltin chloride (TMT) is known to produce neuronal damage in the rat hippocampus, especially in the CA 1 /CA 3 subfields, together with reactive astrogliosis. Previous studies indicate that in cultured rat hippocampal neurons the Ca 2+ cytosoli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb0f3ced3a2b898b4f8682b8436cb3e
https://pubmed.ncbi.nlm.nih.gov/21111789

In vivo morphological changes in animal models of amyotrophic lateral sclerosis and Alzheimer's-like disease: MRI approach

Autor: Pavle R. Andjus, Goran Bačić, Charles Nicaise, Carlo Gangitano, Greetje Vanhoutte, Dinko Mitrečić, Annemie Van der Linden, Danijela Bataveljic, Fabrice Gankam Kengne, Fabrizio Pizzolante, Fabrizio Michetti, Roland Pochet, Nevena Djogo

Publikováno v: The anatomical record: advances in integrative anatomy and evolutionary biology

NMR imaging approach was used to show specific pathological changes in the brain tissue during development of Alzheimer and ALS diseases. Magnetic resonance imaging (MRI) is the only noninvasive technique that provides structural information on both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd9ea7c14a9cd7606fff8f955385dd3
http://hdl.handle.net/10807/5452