Výsledky vyhledávání - "Carlo Calacsan"

Optimization, Production, and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen

Autor: John D. Campbell, Holger Kanzler, Carlo Calacsan, Melissa A. Kachura, Bob Milley, Gary Ott, Robert L. Coffman, Radwan Kiwan

Publikováno v: Bioconjugate Chemistry

We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed from an amine-functionalized-Ficoll, a heterobifunctional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481d8a99f550a71eef73bfe35ac8fd4a
http://europepmc.org/articles/PMC4873889

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A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys

Autor: Holger Kanzler, John D. Campbell, Robert Milley, Atul Sathe, Melissa A. Kachura, Sariah A. Kell, Robert L. Coffman, Brian E. Hall, Carlo Calacsan, Gary Ott, Radwan Kiwan, Colin Hickle

Publikováno v: The Journal of Immunology. 196:284-297

Nanoparticulate delivery systems for vaccine adjuvants, designed to enhance targeting of secondary lymphoid organs and activation of APCs, have shown substantial promise for enhanced immunopotentiation. We investigated the adjuvant activity of synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59d57512806485ab21bd54fc166dc94
https://doi.org/10.4049/jimmunol.1501903

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Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

Autor: Robert L. Coffman, Franck J. Barrat, Jean H. Chan, Carlo Calacsan, Emily Damon, Tracy Matray, Cristiana Guiducci, Gary Ott, Kyung Dall Lee

Publikováno v: The Journal of Experimental Medicine

Human plasmacytoid dendritic cells (PDCs) can produce interferon (IFN)-alpha and/or mature and participate in the adaptive immune response. Three classes of CpG oligonucleotide ligands for Toll-like receptor (TLR)9 can be distinguished by different s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f71781998d337cd83c235ad294eff7
https://doi.org/10.1084/jem.20060401

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Abstract 5596: Intratumoral administration of a TLR9-adjuvanted nanoparticle cancer vaccine stimulates more effective immunity in both injected and un-injected tumor sites compared to subcutaneous administration

Autor: Thomas Tüting, Milley Robert J, Robert L. Coffman, Edwina Naik, Stewart D. Chipman, Cristiana Guiducci, Chi Ying, Carlo Calacsan

Publikováno v: Cancer Research. 77:5596-5596

Therapeutic success of a cancer vaccine requires substantial expansion of vaccine-primed CTL and efficient differentiation to polyfunctional T cells capable of migrating from the site of vaccination to metastatic sites. We have evaluated the tumor it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e4a1566dd42723fc3f5a1641e21a2fe
https://doi.org/10.1158/1538-7445.am2017-5596

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