Is chimerism associated with cancer across the tree of life?

Autor: Stefania E Kapsetaki, Angelo Fortunato, Zachary Compton, Shawn M Rupp, Zaid Nour, Skyelyn Riggs-Davis, Dylan Stephenson, Elizabeth G Duke, Amy M Boddy, Tara M Harrison, Carlo C Maley, Athena Aktipis

Publikováno v: PLoS ONE, Vol 18, Iss 6, p e0287901 (2023)

Chimerism is a widespread phenomenon across the tree of life. It is defined as a multicellular organism composed of cells from other genetically distinct entities. This ability to 'tolerate' non-self cells may be linked to susceptibility to diseases

Externí odkaz: https://doaj.org/article/25870cd70dd244b2b5291cd0f79717df

Bulk Genotyping of Biopsies Can Create Spurious Evidence for Hetereogeneity in Mutation Content.

Autor: Rumen Kostadinov, Carlo C Maley, Mary K Kuhner

Publikováno v: PLoS Computational Biology, Vol 12, Iss 4, p e1004413 (2016)

When multiple samples are taken from the neoplastic tissues of a single patient, it is natural to compare their mutation content. This is often done by bulk genotyping of whole biopsies, but the chance that a mutation will be detected in bulk genotyp

Externí odkaz: https://doaj.org/article/0d2f21bcfc1c4e3584056c5c1b175035

Solving the puzzle of metastasis: the evolution of cell migration in neoplasms.

Autor: Jun Chen, Kathleen Sprouffske, Qihong Huang, Carlo C Maley

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e17933 (2011)

Metastasis represents one of the most clinically important transitions in neoplastic progression. The evolution of metastasis is a puzzle because a metastatic clone is at a disadvantage in competition for space and resources with non-metastatic clone

Externí odkaz: https://doaj.org/article/59e7f2fc13154b7e974a5cbb615ff2e7

Animal cell differentiation patterns suppress somatic evolution.

Autor: John W Pepper, Kathleen Sprouffske, Carlo C Maley

Publikováno v: PLoS Computational Biology, Vol 3, Iss 12, p e250 (2007)

Cell differentiation in multicellular organisms has the obvious function during development of creating new cell types. However, in long-lived organisms with extensive cell turnover, cell differentiation often continues after new cell types are no lo

Externí odkaz: https://doaj.org/article/e92bc3900cc9476091d166f2981968c2

Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus

Autor: Jens Luebeck, Alvin Wei Tian Ng, Patricia C. Galipeau, Xiaohong Li, Carissa A. Sanchez, Annalise C. Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott M. Lippman, Roel G. W. Verhaak, Carlo C. Maley, Ludmil B. Alexandrov, Brian J. Reid, Rebecca C. Fitzgerald, Thomas G. Paulson, Howard Y. Chang, Sihan Wu, Vineet Bafna, Paul S. Mischel

Publikováno v: Luebeck, J, Ng, A W T, Galipeau, P C, Li, X, Sanchez, C A, Katz-Summercorn, A C, Kim, H, Jammula, S, He, Y, Lippman, S M, Verhaak, R G W, Maley, C C, Alexandrov, L B, Reid, B J, Fitzgerald, R C, Paulson, T G, Chang, H Y, Wu, S, Bafna, V & Mischel, P S 2023, ' Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus ', Nature, vol. 616, no. 7958, pp. 798-805 . https://doi.org/10.1038/s41586-023-05937-5
Nature, 616(7958), 798-805. Nature Publishing Group

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer1–6. At present, it is unclear whether ecDNA is a later manifesta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b79f4c574e7c40779822effa0cc3bcc
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