Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Carlo Bonchi"'
Autor:
Valentina Gentile, Emanuela Frangipani, Carlo Bonchi, Fabrizia Minandri, Federica Runci, Paolo Visca
Publikováno v:
Pathogens, Vol 3, Iss 3, Pp 704-719 (2014)
Acinetobacter baumannii is an emerging nosocomial pathogen, responsible for infection outbreaks worldwide. The pathogenicity of this bacterium is mainly due to its multidrug-resistance and ability to form biofilm on abiotic surfaces, which facilitate
Externí odkaz:
https://doaj.org/article/9a39bf74701748cabcebdc5ca1ca13c9
Biofilm-associated infections caused by Acinetobacter baumannii are extremely recalcitrant to antibiotic treatment. We report that A. baumannii develops a mature biofilm when grown in complement-free human serum (HS). We demonstrate that 16 μM galli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcbc34d0aefe1323b915379ba1f1b04
https://hdl.handle.net/11576/2664929
https://hdl.handle.net/11576/2664929
Autor:
Emanuela Frangipani, Andrea Ugolini, Chiara Battocchio, Carlo Meneghini, Carlo Bonchi, Giovanni Polzonetti, Paolo Visca, Francesco Porcaro
Pyochelin (PCH) is a siderophore (extracellural chelator) produced by the pathogenic bacterium Pseudomonas aeruginosa (PAO). PCH is implicated in Iron (Fe3+) transport to PAO, and is crucial for its metabolism and pathogenicity. Due to chemical simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b99c15752e8d60b735c5118aeb61088
https://hdl.handle.net/11576/2664935
https://hdl.handle.net/11576/2664935
Publikováno v:
Future Microbiology. 9:379-397
ABSTRACT: Gallium has a long history as a diagnostic and chemotherapeutic agent. The pharmacological properties of Ga(III) rely on chemical mimicry; when Ga(III) is exogenously supplied to living cells it can replace Fe(III) within target molecules,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45dffaa96d8128ab9eca0ef67da9399
https://doi.org/10.2217/fmb.14.3
https://doi.org/10.2217/fmb.14.3
Publikováno v:
BioFactors. 40:303-312
While the occurrence and spread of antibiotic resistance in bacterial pathogens is vanishing current anti-infective therapies, the antibiotic discovery pipeline is drying up. In the last years, the repurposing of existing drugs for new clinical appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::281e34038b04a50eba93425c6b4a9d99
https://doi.org/10.1002/biof.1159
https://doi.org/10.1002/biof.1159
Autor:
Marcella Facchini, Fabrizia Minandri, Paolo Pasquali, Alessandra Bragonzi, Francesco Imperi, Emanuela Frangipani, Carlo Bonchi, Paolo Visca, Daniela Visaggio
Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and chronic lung infections in cystic fibrosis patients. Iron is essential for bacterial growth, and P. aeruginosa expresses multiple iron uptake systems, whose role in lung inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c6a18e26bb4d5a0311768766dcf1cd
http://hdl.handle.net/11573/928791
http://hdl.handle.net/11573/928791
Autor:
Carlo Bonchi, Maurizio Sanguinetti, Stefania Sanfilippo, Silvia D'Arezzo, Giorgio Maccari, Maurizio Botta, Dominique Sanglard, Francesca Bugli, Davide Deodato, Filomena De Luca, Patrick Vandeputte, Alexandru Casian, Brunella Posteraro, Paolo Visca, Jean Denis Docquier, Riccardo Martini
We recently identified a novel family of macrocyclic amidinoureas showing potent antifungal activity against Candida spp. In this study, we demonstrate the fungicidal effect of these compounds as well as their killing activity in a dose-dependent man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58c5ecc90b5d2bffa98d10522fb857d
http://hdl.handle.net/10807/73657
http://hdl.handle.net/10807/73657
Gallium is an iron mimetic which has recently been repurposed as an antibacterial agent due to its capability to disrupt bacterial iron metabolism. In this study, the antibacterial activity of gallium nitrate [Ga(NO 3 ) 3 ] was investigated in comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caad0e29514823b6e60440e766915bc5
https://hdl.handle.net/11590/287287
https://hdl.handle.net/11590/287287
Autor:
Paolo Visca, Carlo Bonchi, Fabrizia Minandri, Valentina Gentile, Emanuela Frangipani, Federica Runci
Publikováno v:
Pathogens, Vol 3, Iss 3, Pp 704-719 (2014)
Pathogens; Volume 3; Issue 3; Pages: 704-719
Pathogens
Pathogens; Volume 3; Issue 3; Pages: 704-719
Pathogens
Acinetobacter baumannii is an emerging nosocomial pathogen, responsible for infection outbreaks worldwide. The pathogenicity of this bacterium is mainly due to its multidrug-resistance and ability to form biofilm on abiotic surfaces, which facilitate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b2db6e3b10e6f0a8350af8ccfb84c1
https://hdl.handle.net/11590/122402
https://hdl.handle.net/11590/122402
Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa , the effect of complexation with a variety of siderophores and synthetic chela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94016e3ba0feb28cb40554551f1bce58
https://hdl.handle.net/11590/134136
https://hdl.handle.net/11590/134136