Iron deficiency, elevated erythropoietin, fibroblast growth factor 23, and mortality in the general population of the Netherlands: A cohort study.

Autor: Michele F Eisenga, Maarten A De Jong, Peter Van der Meer, David E Leaf, Gerwin Huls, Ilja M Nolte, Carlo A J M Gaillard, Stephan J L Bakker, Martin H De Borst

Publikováno v: PLoS Medicine, Vol 16, Iss 6, p e1002818 (2019)

BackgroundEmerging data in chronic kidney disease (CKD) patients suggest that iron deficiency and higher circulating levels of erythropoietin (EPO) stimulate the expression and concomitant cleavage of the osteocyte-derived, phosphate-regulating hormo

Externí odkaz: https://doaj.org/article/aebb6109169b46568c9d687a6be506ec

Nutritional Status in Nocturnal Hemodialysis Patients - A Systematic Review with Meta-Analysis.

Autor: Karin J R Ipema, Simone Struijk, Annet van der Velden, Ralf Westerhuis, Cees P van der Schans, Carlo A J M Gaillard, Wim P Krijnen, Casper F M Franssen

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0157621 (2016)

BACKGROUND:Hemodialysis patients experience an elevated risk of malnutrition associated with increased morbidity and mortality. Nocturnal hemodialysis (NHD) results in more effective removal of waste products and fluids. Therefore, diet and fluid res

Externí odkaz: https://doaj.org/article/8ac9a7403bc24d16b569adb4689ad897

Relation between Red Cell Distribution Width and Fibroblast Growth Factor 23 Cleaving in Patients with Chronic Kidney Disease and Heart Failure.

Autor: Fenna van Breda, Mireille E Emans, Karien van der Putten, Branko Braam, Frans J van Ittersum, Rob J Kraaijenhagen, Martin H de Borst, Marc Vervloet, Carlo A J M Gaillard

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128994 (2015)

In chronic kidney disease (CKD), both anemia and deregulated phosphate metabolism are common and predictive of adverse outcome. Previous studies suggest that iron status influences phosphate metabolism by modulating proteolytic cleavage of FGF23 into

Externí odkaz: https://doaj.org/article/fd3b7d3ef256421a99ac2af43a9fa732

Effect of Intravenous Ferric Carboxymaltose on Exercise Capacity After Kidney Transplantation (EFFECT-KTx): rationale and study protocol for a double-blind, randomised, placebo-controlled trial

Autor: Joanna SJ Vinke, Michele F Eisenga, Jan-Stephan F Sanders, Stefan P Berger, Jacoba M Spikman, Wayel H Abdulahad, Stephan JL Bakker, Carlo A J M Gaillard, Arjan D van Zuilen, P van der Meer, Martin H de Borst

Publikováno v: BMJ Open, 13(3):e065423. BMJ PUBLISHING GROUP

IntroductionIron deficiency (ID) is common and has been associated with an excess mortality risk in kidney transplant recipients (KTRs). In patients with chronic heart failure and ID, intravenous iron improves exercise capacity and quality of life. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea520fee689d37cc0cb969183174dc6
https://research.rug.nl/en/publications/5cb6f8f2-f5bd-48d7-a234-ad6b2f2ebe11

Interplay of erythropoietin, fibroblast growth factor 23, and erythroferrone in patients with hereditary hemolytic anemia

Autor: Stephanie van Straaten, Stephan J. L. Bakker, Michele F Eisenga, Richard van Wijk, Martin H. de Borst, Andreas Glenthøj, Annelies J. Van Vuren, Carlo A. J. M. Gaillard, Eduard J. van Beers

Publikováno v: van Vuren, A J, Eisenga, M F, van Straaten, S, Glenthøj, A, Gaillard, C A J M, Bakker, S J L, de Borst, M H, van Wijk, R & van Beers, E J 2020, ' Interplay of erythropoietin, fibroblast growth factor 23, and erythroferrone in patients with hereditary hemolytic anemia ', Blood advances, vol. 4, no. 8, pp. 1678-1682 . https://doi.org/10.1182/bloodadvances.2020001595
Blood, 4(8), 1678-1682. AMER SOC HEMATOLOGY

Recently, erythropoietin (EPO) was identified as regulator of fibroblast growth factor 23 (FGF23). Proteolytic cleavage of biologically active intact FGF23 (iFGF23) results in the formation of C-terminal fragments (cFGF23). An increase in cFGF23 rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca45755baf1eec5e044c495f788e2da
https://doi.org/10.1182/bloodadvances.2020001595