Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Carlo Pergola"'
Autor:
Donatello Laera, Camilla Scarpellini, Simona Tavarini, Barbara Baudner, Agnese Marcelli, Carlo Pergola, Malte Meppen, Derek T. O’Hagan
Publikováno v:
Vaccines, Vol 11, Iss 1, p 155 (2023)
Although aluminium-based vaccines have been used for almost over a century, their mechanism of action remains unclear. It is established that antigen adsorption to the adjuvant facilitates delivery of the antigen to immune cells at the injection site
Externí odkaz:
https://doaj.org/article/bde4b3d88f134f58a8bbf43e489a53f6
Autor:
Domenico Rizzo, Linda Cerofolini, Stefano Giuntini, Luisa Iozzino, Carlo Pergola, Francesca Sacco, Angelo Palmese, Enrico Ravera, Claudio Luchinat, Fabio Baroni, Marco Fragai
Publikováno v:
Journal of the American Chemical Society
Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins designed to bind pharmacological targets are covalently linked or expressed as fusion proteins to increase both therapeutic efficacy and safety. Epitope mappi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24109ed6388f9fe18820c8f85cca229
https://doi.org/10.1021/jacs.2c03232
https://doi.org/10.1021/jacs.2c03232
Autor:
Elisa Lipari, Simona Saporiti, Ivano Eberini, Luigia Massimo, Enrico Mazzarella, Giulia Anderloni, Mara Rossi, Fabio D'Amici, Carlo Pergola, Wolf Palinsky, Cosimo Walter D'Acunto, Fabio Centola
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 42(6)
Interferon beta (IFNβ) is a well-known cytokine, belonging to the type I family, that exerts antiviral, immunomodulatory, and antiproliferative activity. It has been reported that the artificially deamidated form of recombinant IFNβ-1a at Asn25 pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a988915455d8c225945d33f14c281c7f
https://pubmed.ncbi.nlm.nih.gov/35527626
https://pubmed.ncbi.nlm.nih.gov/35527626
Publikováno v:
The Scientific World Journal, Vol 7, Pp 56-74 (2007)
The leukotrienes (LTs) are metabolic products of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. The biological activities of LTs suggest that they are mediators of acute inflammatory and immediate hypersensitivity responses. In particular, t
Externí odkaz:
https://doaj.org/article/9c7bafbca4c94fa68c99dcc110513301
Autor:
Ivano Eberini, Fabio Centola, Carlo Pergola, Chiara Parravicini, S. Saporiti, Uliano Guerrini, Mara Rossi
Publikováno v:
Biophys J
Currently, monoclonal antibodies (mAbs) are the most used biopharmaceuticals for human therapy. One of the key aspects in their development is the control of effector functions mediated by the interaction between fragment crystallizable (Fc) and Fcγ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ed047332f0cde6ce4cae282cd5d163
https://pubmed.ncbi.nlm.nih.gov/34710380
https://pubmed.ncbi.nlm.nih.gov/34710380
Autor:
Alessandra Pistacchio, Fabio Baroni, Irene Cecchini, Roberta Verani, Mariano Stornaiuolo, Angelo Palmese, Carlo Pergola
Publikováno v:
European Journal of Pharmaceutical Sciences. 172:106139
A key aspect that must be supervised during the development of a biotherapeutic is the presence of elemental impurities in the final drug product: they must be quantified as to ensure that their concentrations does not affect patients’ safety. Regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4d8631c0bcc92f2eed4592fd601e14
https://doi.org/10.1016/j.ejps.2022.106139
https://doi.org/10.1016/j.ejps.2022.106139
Autor:
Roshan Goswami, Barbara Baudner, Derek T. O'Hagan, Roberto Adamo, Ilaria Ferlenghi, Francesco Berti, Simona Gallorini, Alessandra Bonci, Marianna Taccone, Despo Chatzikleanthous, Gustavo Lou, Michela Brazzoli, Fabiola Giusti, Carlo Pergola
Publikováno v:
ACS Infectious Diseases
Mannosylation of Lipid Nanoparticles (LNP) can potentially enhance uptake by Antigen Presenting Cells, which are highly abundant in dermal tissues, to improve the potency of Self Amplifying mRNA (SAM) vaccines in comparison to the established unmodif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b66e0acb38cb0d3086a8ad5a9ac5e7
https://pubmed.ncbi.nlm.nih.gov/31290323
https://pubmed.ncbi.nlm.nih.gov/31290323
Autor:
Anna Czapka, Stefanie König, Alexios-Leandros Skaltsounis, Carlo Pergola, Oliver Werz, Konstantina Vougogiannopoulou, Christian Grune, Dagmar Fischer
Publikováno v:
Biochemical Pharmacology. 180:114170
Indirubin is a natural bis-indole alkaloid contained as active ingredient in the traditional Chinese remedy Danggui Longhui Wan. Indirubin and its 3′-oxime derivatives exhibit anti-cancer and anti-inflammatory properties and they inhibit glycogen s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3e81c9ec39f57b128b5dd28dc05f83
https://doi.org/10.1016/j.bcp.2020.114170
https://doi.org/10.1016/j.bcp.2020.114170
Autor:
Jutta Haunschild, Katja Wosikowski, Carlo Pergola, Jan Seibel, Martin D. Lehner, Oliver Werz, Kirill Kryshen
Publikováno v:
Phytomedicine. 22:1172-1177
Background/purpose Acute bronchitis (AB) is a common lung condition characterized by inflammation of the large bronchi in response to infection. Bronchipret® syrup (BRO), a fixed combination of thyme and ivy extracts has been effectively used for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95feb16ca6cd41f14708da3744b6c8f3
https://doi.org/10.1016/j.phymed.2015.09.001
https://doi.org/10.1016/j.phymed.2015.09.001
Autor:
Eirini Kouloura, Antonietta Rossi, Lidia Sautebin, Alexios-Leandros Skaltsounis, Simona Pace, Ulrike Garscha, Carlo Pergola, Verena Krauth, Oliver Werz, Maria Halabalaki, Nicolas Gaboriaud-Kolar, Alexandra Svouraki
Publikováno v:
Journal of natural products. 80(3)
Among the pathways responsible for the development of inflammatory responses, the cyclooxygenase and lipoxygenase pathways are among the most important ones. Two key enzymes, namely, 5-LO and mPGES-1, are involved in the biosynthesis of leukotrienes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998d28c345f86427dacb785f74374da0
https://pubmed.ncbi.nlm.nih.gov/28240894
https://pubmed.ncbi.nlm.nih.gov/28240894