Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Carlo, Tacchetti"'
Autor:
Matteo Sorge, Giulia Savoré, Andrea Gallo, Davide Acquarone, Mauro Sbroggiò, Silvia Velasco, Federica Zamporlini, Saveria Femminò, Enrico Moiso, Giampaolo Morciano, Elisa Balmas, Andrea Raimondi, Gabrielle Nattenberg, Rachele Stefania, Carlo Tacchetti, Angela Maria Rizzo, Paola Corsetto, Alessandra Ghigo, Emilia Turco, Fiorella Altruda, Lorenzo Silengo, Paolo Pinton, Nadia Raffaelli, Nathan J Sniadecki, Claudia Penna, Pasquale Pagliaro, Emilio Hirsch, Chiara Riganti, Guido Tarone, Alessandro Bertero, Mara Brancaccio
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2450-2484 (2024)
Abstract Defining the molecular mechanisms underlying cardiac resilience is crucial to find effective approaches to protect the heart. A physiologic level of ROS is produced in the heart by fatty acid oxidation, but stressful events can boost ROS and
Externí odkaz:
https://doaj.org/article/fbbe12027f6940b5871e50bcfc957a2f
Autor:
Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114970- (2024)
Externí odkaz:
https://doaj.org/article/b2ea199df0684449960748dac3c283bb
Autor:
Deborah Mesa, Elisa Barbieri, Andrea Raimondi, Stefano Freddi, Giorgia Miloro, Gorana Jendrisek, Giusi Caldieri, Micaela Quarto, Irene Schiano Lomoriello, Maria Grazia Malabarba, Arianna Bresci, Francesco Manetti, Federico Vernuccio, Hind Abdo, Giorgio Scita, Letizia Lanzetti, Dario Polli, Carlo Tacchetti, Paolo Pinton, Massimo Bonora, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract One open question in the biology of growth factor receptors is how a quantitative input (i.e., ligand concentration) is decoded by the cell to produce specific response(s). Here, we show that an EGFR endocytic mechanism, non-clathrin endocyt
Externí odkaz:
https://doaj.org/article/1aea93372b324f868e8be4a452c68516
Autor:
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1324-1351 (2024)
Abstract Clear-cell renal cell carcinoma (ccRCC), the major subtype of RCC, is frequently diagnosed at late/metastatic stage with 13% 5-year disease-free survival. Functional inactivation of the wild-type p53 protein is implicated in ccRCC therapy re
Externí odkaz:
https://doaj.org/article/943d98c6d7a140ae919de5ddf5a741fd
Autor:
Matteo Mazzocca, Alessia Loffreda, Emanuele Colombo, Tom Fillot, Daniela Gnani, Paola Falletta, Emanuele Monteleone, Serena Capozi, Edouard Bertrand, Gaelle Legube, Zeno Lavagnino, Carlo Tacchetti, Davide Mazza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple factors explore chromatin, combining live-cell single-molecule tracking with multifoca
Externí odkaz:
https://doaj.org/article/ad0df2d97361490abffab1918d47a1fd
Autor:
Massimo Venturini, Rosanna Mezzapelle, Salvatore La Marca, Laura Perani, Antonello Spinelli, Luca Crippa, Anna Colarieti, Anna Palmisano, Paolo Marra, Andrea Coppola, Federico Fontana, Giulio Carcano, Carlo Tacchetti, Marco Bianchi, Antonio Esposito, Massimo P. Crippa
Publikováno v:
European Radiology Experimental, Vol 6, Iss 1, Pp 1-10 (2022)
Abstract Background Malignant mesothelioma (MM) is an aggressive tumor, with a poor prognosis, usually unresectable due to late diagnosis, mainly treated with chemotherapy. BoxA, a truncated form of “high mobility group box 1” (HMGB1), acting as
Externí odkaz:
https://doaj.org/article/1c92f0702dae449bbc1c7a4e43556191
Autor:
Marco Toselli, Antonio Esposito, Anna Palmisano, Davide Vignale, Valeria Nicoletti, Riccardo Leone, Chiara Gnasso, Alberto Monello, Arif A. Khokhar, Alessandra Laricchia, Andrea Biagi, Piergiorgio Turchio, Marcello Petrini, Guglielmo Gallone, Francesco De Cobelli, Francesco Ponticelli, Gianni Casella, Carlo Tacchetti, Antonio Colombo, Francesco Giannini
Publikováno v:
Anatolian Journal of Cardiology, Vol 25, Iss 6, Pp 376-379 (2021)
Externí odkaz:
https://doaj.org/article/c2983ae58d174330b1b19f95915193d2
Autor:
Mara Biasin, Sergio Strizzi, Andrea Bianco, Alberto Macchi, Olga Utyro, Giovanni Pareschi, Alessia Loffreda, Adalberto Cavalleri, Manuela Lualdi, Daria Trabattoni, Carlo Tacchetti, Davide Mazza, Mario Clerici
Publikováno v:
Journal of Photochemistry and Photobiology, Vol 10, Iss , Pp 100107- (2022)
We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose
Externí odkaz:
https://doaj.org/article/444914365f58414288189e28588b0183
Autor:
Claudio Fenizia, Silvia Galbiati, Claudia Vanetti, Riccardo Vago, Mario Clerici, Carlo Tacchetti, Tiziana Daniele
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 1 (2022)
ABSTRACT In December 2019, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started spreading worldwide causing the coronavirus disease 2019 (COVID-19) pandemic. The hyperactivation of the immune system has been proposed to account
Externí odkaz:
https://doaj.org/article/349d049ec28d41efa190626428dee691
Autor:
Samuel Zambrano, Alessia Loffreda, Elena Carelli, Giacomo Stefanelli, Federica Colombo, Edouard Bertrand, Carlo Tacchetti, Alessandra Agresti, Marco E. Bianchi, Nacho Molina, Davide Mazza
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101529- (2020)
Summary: Nuclear factor (NF)-κB controls the transcriptional response to inflammatory signals by translocating into the nucleus, but we lack a single-cell characterization of the resulting transcription dynamics. Here we show that upon tumor necrosi
Externí odkaz:
https://doaj.org/article/6e8e669d5ae54817b3343b02e8876ff9