Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Carlo, Condello"'
Autor:
Ujjayini Ghosh, Eric Tse, Hyunjun Yang, Marie Shi, Christoffer D. Caro, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth, Carlo Condello
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Down syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among their complex clinical features, including musculoskeletal, neurological, and cardiovascular disabilities, individuals with DS have an increased risk
Externí odkaz:
https://doaj.org/article/aac87a63fb79463b9e1a637cad62d4a9
Autor:
Noah R. Johnson, Peng Yuan, Erika Castillo, T. Peter Lopez, Weizhou Yue, Annalise Bond, Brianna M. Rivera, Miranda C. Sullivan, Masakazu Hirouchi, Kurt Giles, Atsushi Aoyagi, Carlo Condello
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Tau-mediated neurodegeneration is driven by disease-activated microglia and suppressed by their pharmacological blockade. The authors identified drug dose- and sex-dependent residual microglial phenotypes, neuronal excitotoxicity, and animal survival
Externí odkaz:
https://doaj.org/article/b48523c2ca3f4e85a7a80f256c64823a
Autor:
Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.
Externí odkaz:
https://doaj.org/article/1f855da0da7c4c2995106bb45af63b8f
Autor:
Alison M. Maxwell, Peng Yuan, Brianna M. Rivera, Wilder Schaaf, Mihovil Mladinov, Vee P. Prasher, Andrew C. Robinson, William F. DeGrado, Carlo Condello
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Amyloid beta (Aβ) is thought to play a critical role in the pathogenesis of Alzheimer’s disease (AD). Prion-like Aβ polymorphs, or “strains”, can have varying pathogenicity and may underlie the phenotypic heterogeneity of the disease
Externí odkaz:
https://doaj.org/article/dce996dec328498197f03187eecb924c
Autor:
Carlo Condello, Jan Stöehr
Publikováno v:
Neurobiology of Disease, Vol 109, Iss , Pp 191-200 (2018)
The progressive nature of Alzheimer's disease (AD) is thought to occur, at least in part, by the self-replication and spreading of Aβ and Tau aggregates through a prion mechanism. Evidence now exists that structural variants of Aβ prions can propag
Externí odkaz:
https://doaj.org/article/625fbbf1ef944a2084b0bae8b00326c8
Autor:
T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson, Stanley B. Prusiner
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-14 (2017)
Abstract The larger brain of the rat enables a much greater repertoire of complex behaviors than mice, likely making rats preferential for investigating neurodegeneration. Because molecular tools for specific expression of transgenes in the rat brain
Externí odkaz:
https://doaj.org/article/4d2ddaa7092d4483846eb34d52edf9b7
Autor:
Gayani Wijegunawardena, Erika Castillo, Brandy Henrickson, Regan Davis, Carlo Condello, Haifan Wu
Publikováno v:
ACS Chemical Neuroscience.
Mutations in a microglia-associated geneTREM2increase the risk of Alzheimer’s disease. Currently, structural and functional studies of TREM2 mainly rely on recombinant TREM2 proteins expressed from mammalian cells. However, using this method, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16b4be5f22bbd9bd7e4b58b3448a13e
https://doi.org/10.1021/acschemneuro.3c00257
https://doi.org/10.1021/acschemneuro.3c00257
Autor:
Carlo Condello, Jacob I. Ayers, Clifton L. Dalgard, M. Madhy Garcia Garcia, Brianna M. Rivera, William W. Seeley, Daniel P. Perl, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 13
The amyotrophic lateral sclerosis–parkinsonism dementia complex (ALS-PDC) of Guam is an endemic neurodegenerative disease that features widespread tau tangles, occasional α-synuclein Lewy bodies, and sparse β-amyloid (Aβ) plaques distributed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54ea140606db813bc60784ff7829754
https://doi.org/10.1073/pnas.2220984120
https://doi.org/10.1073/pnas.2220984120
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626542
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0253a384510f6c5440c86b4584df75
https://doi.org/10.1007/978-1-0716-2655-9_16
https://doi.org/10.1007/978-1-0716-2655-9_16
Autor:
Carlo Condello, Alison M. Maxwell, Erika Castillo, Atsushi Aoyagi, Caroline Graff, Martin Ingelsson, Lars Lannfelt, Thomas D. Bird, C. Dirk Keene, William W. Seeley, Daniel P. Perl, Elizabeth Head, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 46
Down syndrome (DS) is caused by the triplication of chromosome 21 and is the most common chromosomal disorder in humans. Those individuals with DS who live beyond age 40 y develop a progressive dementia that is similar to Alzheimer’s disease (AD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be000958ffcf6244782d2540a78a3911
https://pubmed.ncbi.nlm.nih.gov/36343257
https://pubmed.ncbi.nlm.nih.gov/36343257