Different Adaptive Responses to Hypoxia in Normal and Multiple Myeloma Endothelial Cells

Autor: Irene Filippi, Ilaria Saltarella, Carlo Aldinucci, Fabio Carraro, Roberto Ria, Angelo Vacca, Antonella Naldini

Publikováno v: Cellular Physiology and Biochemistry, Vol 46, Iss 1, Pp 203-212 (2018)

Background/Aims: Hypoxia is a powerful stimulator of angiogenesis under physiological as well as pathological conditions. Normal endothelial cells (EC), such as human umbilical vein EC (HUVEC), are relatively affected by hypoxic insult in terms of ce

Externí odkaz: https://doaj.org/article/5b4e4f72cf1b4547ab6fcb002b7cb9cc

Hypoxia shapes autophagy in LPS-activated dendritic cells

Autor: Antonella Naldini, Daniela Rossi, Irene Filippi, Sara Monaci, Fabio Carraro, Silvano Sozzani, Cristina Ulivieri, Giuseppe Marotta, Gaia Giuntini, Carlo Aldinucci

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology

During their lifespan, dendritic cells (DCs) are exposed to different pO2 levels that affect their differentiation and functions. Autophagy is one of the adaptive responses to hypoxia with important implications for cell survival. While the autophagi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c9cc25ee6fc37b4a734e91ea13fff7
http://hdl.handle.net/11573/1475223

Different adaptive responses to hypoxia in normal and multiple myeloma endothelial cells

Autor: Roberto Ria, Fabio Carraro, Ilaria Saltarella, Antonella Naldini, Angelo Vacca, Carlo Aldinucci, Irene Filippi

Publikováno v: Cellular Physiology and Biochemistry, Vol 46, Iss 1, Pp 203-212 (2018)

Background/Aims: Hypoxia is a powerful stimulator of angiogenesis under physiological as well as pathological conditions. Normal endothelial cells (EC), such as human umbilical vein EC (HUVEC), are relatively affected by hypoxic insult in terms of ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1a07433b09b9809fe8ef9c6359f847
http://hdl.handle.net/11365/1035979

Neuroprotective Effects ofCastanea sativaMill. Bark Extract in Human Neuroblastoma Cells Subjected to Oxidative Stress

Autor: Claudia Brizi, Roberta Budriesi, Maria Frosini, Carlo Aldinucci, Matteo Micucci, Chiara Santulli, Alberto Chiarini

Publikováno v: Journal of Cellular Biochemistry. 117:510-520

One of the major features of neurodegenerative disease is the selective vulnerability of different neuronal populations that are affected in a progressive and often stereotyped manner. Despite the susceptible neuronal population varies between diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7450eb53e2161c12bfcde78fe56fd76e
https://doi.org/10.1002/jcb.25302

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress

Autor: Federico Corelli, Stefano Alcaro, Claudia Sticozzi, Vanessa Maestrini, Luciano De Petrocellis, Francesca Aiello, Francesca Guida, Antonella Brizzi, Marco Allarà, Mariateresa Badolato, Anna Artese, Livio Luongo, Vincenzo Di Marzo, Alessia Ligresti, Carlo Aldinucci, Giosuè Costa, Federica Pessina, Aniello Schiano Moriello, Giuseppe Valacchi, Maria Frosini, Sabatino Maione

Publikováno v: ACS chemical neuroscience 7 (2016): 737–748. doi:10.1021/acschemneuro.5b00333
info:cnr-pdr/source/autori:Aiello, Francesca; Badolato, Mariateresa; Pessina, Federica; Sticozzi, Claudia; Maestrini, Vanessa; Aldinucci, Carlo; Luongo, Livio; Guida, Francesca; Ligresti, Alessia; Artese, Anna; Allara, Marco; Costa, Giosue; Frosini, Maria; Moriello, Aniello Schiano; De Petrocellis, Luciano; Valacchi, Giuseppe; Alcaro, Stefano; Maione, Sabatino; Di Marzo, Vincenzo; Corelli, Federico; Brizzi, Antonella/titolo:Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress/doi:10.1021%2Facschemneuro.5b00333/rivista:ACS chemical neuroscience/anno:2016/pagina_da:737/pagina_a:748/intervallo_pagine:737–748/volume:7

4-(Thiophen-2-yl)butanoic acid was identified as a cyclic substitute of the unsaturated alkyl chain of the natural ligand, capsaicin. Accordingly, a new class of amides was synthesized in good yield and high purity and their molecular recognition aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f720baf8466d9b8f758aa3c345f11f
https://pubmed.ncbi.nlm.nih.gov/26942555