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Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

Autor: Patel, Y. T., Daryani, V. M., Patel, P., Zhou, D., Fangusaro, J., Carlile, D. J., Martin, P. D., Aarons, L., Stewart, C. F.

Publikováno v: Patel, Y T, Daryani, V M, Patel, P, Zhou, D, Fangusaro, J, Carlile, D J, Martin, P D, Aarons, L & Stewart, C F 2017, ' Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas ', CPT: Pharmacometrics and Systems Pharmacology . https://doi.org/10.1002/psp4.12175

Selumetinib (AZD6244, ARRY-142886), a mitogen activated protein kinases (MEK1 and 2) inhibitor, has been granted orphan drug designation for differentiated thyroid cancer. The primary aim of this analysis was to characterize the population pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::6f86f595cb3a4f93aca81cfc4106890c
https://research.manchester.ac.uk/en/publications/830df0bb-ecd4-45cb-9598-1d83ddcf1bd9

Implications and consequences of enzyme induction on preclinical and clinical drug development.

Autor: Worboys, P. D., Carlile, D. J.

Publikováno v: Xenobiotica. Aug/Sept2001, Vol. 31 Issue 8/9, p539-556. 18p. 1 Chart, 5 Graphs.

GLOFITAMAB STEP‐UP DOSING: UPDATED EFFICACY DATA SHOW HIGH COMPLETE RESPONSE RATES IN HEAVILY PRETREATED RELAPSED/REFRACTORY (R/R) NON‐HODGKIN LYMPHOMA (NHL) PATIENTS.

Autor: Carlo‐Stella, C, Hutchings, M, Offner, F. C, Morschhauser, F, Bachy, E, Crump, M, Sureda, A, Iacoboni, G, Haioun, C, Perez‐Callejo, D, Lundberg, L, Relf, J, Clark, E, Carlile, D, Piccione, E, Belousov, A, Humphrey, K, Dickinson, M. J

Publikováno v: Hematological Oncology; Jun2021 Supplement S2, Vol. 39, p1-3, 3p

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