How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease

Autor: Jayron J. Habibe, Maria P. Clemente-Olivo, Carlie J. de Vries

Publikováno v: Cells, Vol 10, Iss 10, p 2611 (2021)

Susceptibility to complex pathological conditions such as obesity, type 2 diabetes and cardiovascular disease is highly variable among individuals and arises from specific changes in gene expression in combination with external factors. The regulatio

Externí odkaz: https://doaj.org/article/9cbbba4e6f494da7a8261404702b43b5

Nuclear receptor Nur77 deficiency alters dendritic cell function

Autor: Carlie J. de Vries, Hiroshi Ichinose, Marleen Ansems, Nina Tel-Karthaus, Esther D. Kers-Rebel, Maaike W. G. Looman

Publikováno v: Frontiers in immunology, 9(AUG):1797. Frontiers Media S.A.
Frontiers in Immunology, 9
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)

Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. Proper function of DCs is crucial to elicit an effective immune response against pathogens and to induce antitumor immunity. Different members of the nuclear re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e97019cb7bb42c2a9939c42790fe18
https://pure.amc.nl/en/publications/nuclear-receptor-nur77-deficiency-alters-dendritic-cell-function(5d5c2cc2-0940-4411-b49d-935f16899776).html

Abstract 480: Aortic Microcalcification Associates With Aortic Elastin Fragmentation in Marfan Syndrome

Autor: Shaynah Wanga, Stijntje Hibender, Yanto Ridwan, Cindy van Roomen, Mariska Vos, Ingeborg van der Made, Nicole van Vliet, Romy Franken, Maarten Groenink, Aeilko H Zwinderman, Barbara J Mulder, Carlie J de Vries, Jeroen Essers, Vivian de Waard

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 37

Marfan syndrome (MFS) is a genetic connective tissue disorder, in which aortic rupture is the major cause of death. MFS patients with an aortic diameter below the advised limit for prophylactic surgery (C1039G/+ MFS aortic SMCs, ALP mRNA and activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::623773232d65cdf115fa02ed38b8455e
https://doi.org/10.1161/atvb.37.suppl_1.480

Abstract 322: Azathioprine Reduces Endothelial Cell Activation via Inhibition of GTPase Rac1

Autor: Goran Marinkovic, Mark Hoogenboezem, Jaap van Buul, Carlie J de Vries, Vivian de Waard

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 33

Objective Azathioprine (AZA) and its active metabolite 6-mercaptopurine (6-MP) are well established immunosuppressive drugs. Common understanding of its immunosuppressive properties is largely limited to immune cells. However, 6-MP also has a potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd1990b51353db5ed4e6e51114b36116
https://doi.org/10.1161/atvb.33.suppl_1.a322

Abstract 62: Azathioprine Is Protective in Aneurysm Formation and Progression

Autor: Goran Marinkovic, Stijntje Hibender, Carlie J de Vries, Vivian de Waard

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 32

Objective: An aortic aneurysm is a dilatation of the arterial wall caused by destruction of its integrity, which results in often lethal vessel ruptures. Currently, only surgical treatment is available for patients with growing aortic aneurysms, ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7655b105d24b94d0ae9bcc30795a2c0d
https://doi.org/10.1161/atvb.32.suppl_1.a62