Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor.

Autor: Thijs W H Pols, Teresa Puchner, H Inci Korkmaz, Mariska Vos, Maarten R Soeters, Carlie J M de Vries

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0176715 (2017)

Bile acids are established signaling molecules next to their role in the intestinal emulsification and uptake of lipids. We here aimed to identify a potential interaction between bile acids and CD4+ Th cells, which are central in adaptive immune resp

Externí odkaz: https://doaj.org/article/ea3e342f404245548b1732c20e8621b8

Effect of anti-ApoA-I antibody-coating of stents on neointima formation in a rabbit balloon-injury model.

Autor: Aart C Strang, Menno L W Knetsch, Leo H Koole, Robbert J de Winter, Allard C van der Wal, Carlie J M de Vries, Paul P Tak, Radjesh J Bisoendial, Erik S G Stroes, Joris I Rotmans

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0122836 (2015)

Since high-density lipoprotein (HDL) has pro-endothelial and anti-thrombotic effects, a HDL recruiting stent may prevent restenosis. In the present study we address the functional characteristics of an apolipoprotein A-I (ApoA-I) antibody coating in

Externí odkaz: https://doaj.org/article/354191a2f30a4e808cd1418e43f51f8b

The LIM-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells.

Autor: Kondababu Kurakula, Mariska Vos, Iker Otermin Rubio, Goran Marinković, Reinhard Buettner, Lukas C Heukamp, Jan Stap, Vivian de Waard, Claudia M van Tiel, Carlie J M de Vries

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94931 (2014)

The LIM-only protein FHL2, also known as DRAL or SLIM3, has a function in fine-tuning multiple physiological processes. FHL2 is expressed in the vessel wall in smooth muscle cells (SMCs) and endothelial cells and conflicting data have been reported o

Externí odkaz: https://doaj.org/article/26b213cef63945599aa7e3cec543a1a3

Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes

Autor: Jayron J. Habibe, Maria P. Clemente-Olivo, Torsten P. M. Scheithauer, Elena Rampanelli, Hilde Herrema, Mariska Vos, Arnout Mieremet, Max Nieuwdorp, Daniel H. van Raalte, Etto C. Eringa, Carlie J. M. de Vries

Publikováno v: Diabetologia, 65(10):s00125-022-05750-1, 1721-1733. Springer, Cham
Diabetologia, 65(10), 1721-1733. Springer Verlag
Habibe, J J, Clemente-Olivo, M P, Scheithauer, T P M, Rampanelli, E, Herrema, H, Vos, M, Mieremet, A, Nieuwdorp, M, van Raalte, D H, Eringa, E C & de Vries, C J M 2022, ' Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes ', Diabetologia, vol. 65, no. 10, pp. 1721-1733 . https://doi.org/10.1007/s00125-022-05750-1

Aims/hypothesis The general population is ageing, involving an enhanced incidence of chronic diseases such as type 2 diabetes. With ageing, DNA methylation of FHL2 increases, as well as expression of the four and a half LIM domains 2 (FHL2) protein i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1a0b6b39ebcc4c030dcc7270ac9cd3
https://doi.org/10.1007/s00125-022-05750-1

Early adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex

Autor: Maria P, Clemente-Olivo, Miguel, Hernández-Quiles, Rinske, Sparrius, Miesje M, van der Stoel, Vera, Janssen, Jayron, Habibe, Janny, van den Burg, Aldo, Jongejan, Paula Sobrevals, Alcaraz, Robert, van Es, Harmjan, Vos, Eric, Kalkhoven, Carlie J M, de Vries

Publikováno v: Cellular Signalling. 104:110587

The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells towards osteoblast and myocyte phenotypes. We hypothesized that FHL2 may simultaneously interfere with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f596e279469ae781694e1dc398a5e107
https://doi.org/10.1016/j.cellsig.2023.110587