Výsledky vyhledávání - "Carlic Huynh"

Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases

Autor: Pankaj Chopra, Carlic Huynh, Jyoti Patel, Tadas S. Vasaitis, Lalji K. Gediya, Jhalak Mehta, Aashvini Belosay, Vincent C. O. Njar, Aakanksha Khandelwal, Puranik Purushottamachar

Publikováno v: Bioorganicmedicinal chemistry. 14(13)

The naturally occurring retinoids and their synthetic analogs play a key role in differentiation, proliferation, and apoptosis, and their use/potential in oncology, dermatology and a variety of diseases are well documented. This review focuses on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ad4c7fcd2da3b686d44f2609a6e6ee
https://pubmed.ncbi.nlm.nih.gov/16530416

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Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice

Autor: Angela Brodie, Olga Goloubeva, Jyoti Patel, Vincent C. O. Njar, Lalji K. Gediya, Carlic Huynh, Dianne Robert Soprano, Ivo P. Nanne, Venkatesh D. Handratta, Omoshile O. Clement

Publikováno v: Journal of medicinal chemistry. 47(27)

Novel retinoic acid metabolism blocking agents (RAMBAs) have been synthesized and characterized. The synthetic features include introduction of nucleophilic ligands at C-4 of all-trans-retinoic acid (ATRA) and 13-cis-retinoic acid, and modification o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10aefd8f34d4d8412ae1d481fd7c2c4
https://pubmed.ncbi.nlm.nih.gov/15615521

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