Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Carli L. Roulston"'
Autor:
Carli L. Roulston, Sarah K. McCann
Publikováno v:
Brain Sciences, Vol 3, Iss 2, Pp 561-598 (2013)
Oxidative stress caused by an excess of reactive oxygen species (ROS) is known to contribute to stroke injury, particularly during reperfusion, and antioxidants targeting this process have resulted in improved outcomes experimentally. Unfortunately t
Externí odkaz:
https://doaj.org/article/1ed62108cfe04465b7eb6a0fd24a07ee
Publikováno v:
Brain Sciences, Vol 3, Iss 1, Pp 294-317 (2013)
NADPH oxidases contribute to brain injury, yet they may also have a role in brain repair, particularly in vascular signaling and angiogenesis. This study determined the temporal and spatial profile of NADPH oxidase subunit expression/activity concurr
Externí odkaz:
https://doaj.org/article/e69c0d42353b4ef3a5a1ffa2252cd5e5
Publikováno v:
Stroke Research and Treatment, Vol 2013 (2013)
NADPH oxidase is a major source of superoxide anion following stroke and reperfusion. This study evaluated the effects of apocynin, a known antioxidant and inhibitor of Nox2 NADPH, on neuronal injury and cell-specific responses to stroke induced in t
Externí odkaz:
https://doaj.org/article/5cfe927aaad1496d985858ecd1171cea
Autor:
S. Sadia Ameen, Nane Griem-Krey, Antoine Dufour, M. Iqbal Hossain, Ashfaqul Hoque, Sharelle Sturgeon, Harshal Nandurkar, Dominik F. Draxler, Robert L. Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S. Lucet, Michael G. Leeming, Dazhi Liu, Amardeep Dhillon, Jet Phey Lim, Faiza Basheer, Hong-Jian Zhu, Laita Bokhari, Carli L. Roulston, Prasad N. Paradkar, Oded Kleifeld, Andrew N. Clarkson, Petrine Wellendorph, Giuseppe D. Ciccotosto, Nicholas A. Williamson, Ching-Seng Ang, Heung-Chin Cheng
Publikováno v:
Ameen, S S, Griem-Krey, N, Dufour, A, Hossain, M I, Hoque, A, Sturgeon, S, Nandurkar, H, Draxler, D F, Medcalf, R L, Kamaruddin, M A, Lucet, I S, Leeming, M G, Liu, D, Dhillon, A, Lim, J P, Basheer, F, Zhu, H J, Bokhari, L, Roulston, C L, Paradkar, P N, Kleifeld, O, Clarkson, A N, Wellendorph, P, Ciccotosto, G D, Williamson, N A, Ang, C S & Cheng, H C 2023, ' N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection ', Molecular & cellular proteomics : MCP, vol. 22, no. 5, 100543 . https://doi.org/10.1016/j.mcpro.2023.100543
Molecular & cellular proteomics : MCP, vol 22, iss 5
Molecular & cellular proteomics : MCP, vol 22, iss 5
Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicity, the ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a980e6e528169653b1b0ed50175569
https://curis.ku.dk/ws/files/357280187/1_s2.0_S1535947623000531_main.pdf
https://curis.ku.dk/ws/files/357280187/1_s2.0_S1535947623000531_main.pdf
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1717
Multiple methods exist to model permanent and transient ischemia under anesthesia in animals, however most human strokes occur while conscious. The use of endothelin-1 as a vasoconstrictor applied to the perivascular surface of the middle cerebral ar
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975242
Multiple methods exist to model permanent and transient ischemia under anesthesia in animals, however most human strokes occur while conscious. The use of endothelin-1 as a vasoconstrictor applied to the perivascular surface of the middle cerebral ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2a47d56bbf7e7b874b810cd1aa08658
https://doi.org/10.1007/978-1-4939-7526-6_10
https://doi.org/10.1007/978-1-4939-7526-6_10
Autor:
Donald J. Fujita, Heung-Chin Cheng, Gregory J. Dusting, Andrew F. Hill, Carli L Roulston, Nicholas A. Williamson, Jeffrey D. Bjorge, Steve N. Cheung, M. Aizuddin Kamaruddin, Tung O. Chan, M. Iqbal Hossain, Dominic C.H. Ng, Percy W.Y. Chu
Publikováno v:
Journal of Biological Chemistry. 288:9696-9709
Excitotoxicity resulting from overstimulation of glutamate receptors is a major cause of neuronal death in cerebral ischemic stroke. The overstimulated ionotropic glutamate receptors exert their neurotoxic effects in part by overactivation of calpain
Autor:
Sarah K. McCann, Carli L Roulston
Publikováno v:
Brain Sciences
Brain Sciences, Vol 3, Iss 2, Pp 561-598 (2013)
Brain Sciences, Vol 3, Iss 2, Pp 561-598 (2013)
Oxidative stress caused by an excess of reactive oxygen species (ROS) is known to contribute to stroke injury, particularly during reperfusion, and antioxidants targeting this process have resulted in improved outcomes experimentally. Unfortunately t
Publikováno v:
Brain Sciences, Vol 3, Iss 1, Pp 294-317 (2013)
Brain Sciences
Brain Sciences; Volume 3; Issue 1; Pages: 294-317
Brain Sciences
Brain Sciences; Volume 3; Issue 1; Pages: 294-317
NADPH oxidases contribute to brain injury, yet they may also have a role in brain repair, particularly in vascular signaling and angiogenesis. This study determined the temporal and spatial profile of NADPH oxidase subunit expression/activity concurr
Publikováno v:
International Journal of Molecular Sciences
Stroke is a common and serious condition, with few therapies. Whilst previous focus has been directed towards biochemical events within neurons, none have successfully prevented the progression of injury that occurs in the acute phase. New targeted t