Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Carley J. S. Heck"'
Autor:
Klarissa D. Jackson, Upendra A. Argikar, Sungjoon Cho, Rachel D. Crouch, James P. Driscoll, Carley J. S. Heck, Lloyd King, Hlaing (Holly) Maw, Grover P. Miller, Herana Kamal Seneviratne, Shuai Wang, Cong Wei, Donglu Zhang, S. Cyrus Khojasteh
Publikováno v:
Drug Metabolism Reviews. 54:246-281
This year's review on bioactivation and reactivity began as a part of the annual review on biotransformation and bioactivation led by Cyrus Khojasteh (see references). Increased contributions from experts in the field led to the development of a stan
Autor:
S. Cyrus Khojasteh, Upendra A. Argikar, Sungjoon Cho, Rachel Crouch, Carley J. S. Heck, Kevin M. Johnson, Amit S. Kalgutkar, Lloyd King, Hlaing (Holly) Maw, Herana Kamal Seneviratne, Shuai Wang, Cong Wei, Donglu Zhang, Klarissa D. Jackson
Publikováno v:
Drug Metabolism Reviews. 54:207-245
Biotransformation field is constantly evolving with new molecular structures and discoveries of metabolic pathways that impact efficacy and safety. Recent review by Kramlinger et al. (2022) nicely captures the future (and the past) of highly impactfu
Publikováno v:
ACS Pharmacology & Translational Science. 3:655-665
Emtricitabine (FTC), tenofovir (TFV), efavirenz (EFV), and rilpivirine (RPV) are currently used as components of HIV combination therapy. Although these drugs are widely used in antiretroviral ther...
Publikováno v:
Journal of Medicinal Chemistry
Cytochrome P450-dependent metabolism of the anti-HIV drug nevirapine (NVP) to 12-hydroxy-NVP (12-OHNVP) has been implicated in NVP toxicities. We investigated the impact of twelfth-position trideuteration (12-D3NVP) on the hepatic metabolism of and r
Publikováno v:
Molecular Pharmacology. 95:183-195
Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates the activation in primary hepatocytes of key cell stress regulators: inositol-requiring 1α
Publikováno v:
ACS Pharmacology & Translational Science
Emtricitabine (FTC), tenofovir (TFV), efavirenz (EFV), and rilpivirine (RPV) are currently used as components of HIV combination therapy. Although these drugs are widely used in antiretroviral therapy, several organ toxicities related to TFV and EFV
Publikováno v:
Molecular pharmacology. 95(2)
Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates the activation in primary hepatocytes of key cell stress regulators: inositol-requiring 1α
Publikováno v:
The FASEB Journal. 32
Publikováno v:
The FASEB Journal. 32
Autor:
Julie M. Lade, Bhargavi Narayanan, Kevin D. Dietz, Herschel Wade, Namandjé N. Bumpus, Carley J. S. Heck
Efavirenz (EFV), an antiretroviral that interacts clinically with co-administered drugs via activation of the pregnane X receptor (PXR), is extensively metabolized by the cytochromes P450. We tested whether its primary metabolite, 8-hydroxyEFV (8-OHE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb96172dfd540c3289c6303ef19bf68b
https://europepmc.org/articles/PMC6081956/
https://europepmc.org/articles/PMC6081956/