Výsledky vyhledávání - "Carleton M. Sherman"

Akademický článek

Mycobacterium tuberculosis sterilizing activity of faropenem, pyrazinamide and linezolid combination and failure to shorten the therapy duration

Autor: Tawanda Gumbo, Carleton M. Sherman, Devyani Deshpande, Jan-Willem Alffenaar, Shashikant Srivastava

Publikováno v: International Journal of Infectious Diseases, Vol 104, Iss , Pp 680-684 (2021)

Background: Faropenem (F), an orally bioavailable β-lactam, kills Mycobacterium tuberculosis (Mtb) without the help of a β-lactamase inhibitor. This study explored the sterilizing effect of adding F once or twice daily to a linezolid (L) plus pyraz

Externí odkaz: https://doaj.org/article/f3407f9be2194bff8b6b6e1f295895fd

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A Long-term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies

Autor: Jotam G. Pasipanodya, Tawanda Gumbo, Kayle N Cirrincione, Shashikant Srivastava, Devyani Deshpande, Carleton M. Sherman, Stephen Shuford, Soumya Swaminathan, Geetha Ramachandran, Howland E. Crosswell

Publikováno v: EBioMedicine

Treatment of disseminated tuberculosis in children ≤ 6 years has not been optimized. The pyrazinamide-containing combination regimen used to treat disseminated tuberculosis in babies and toddlers was extrapolated from adult pulmonary tuberculosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d868ee32c4a72706bde77bfc798840
http://europepmc.org/articles/PMC4856747

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A 'shock and awe' thioridazine and moxifloxacin combination-based regimen for pulmonary Mycobacterium avium-intracellulare complex disease

Autor: Shashikant Srivastava, Devyani Deshpande, Carleton M. Sherman, Tawanda Gumbo

Publikováno v: The Journal of antimicrobial chemotherapy. 72(suppl_2)

Objectives To develop a thioridazine/moxifloxacin-based combination regimen for treatment of pulmonary infection due to Mycobacterium avium-intracellulare complex (MAC) that kills bacteria faster than the standard treatment regimen. Methods Monocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5872527a73a33f9fdb59d32808af71
https://pubmed.ncbi.nlm.nih.gov/28922810

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Linezolid Dose That Maximizes Sterilizing Effect While Minimizing Toxicity and Resistance Emergence for Tuberculosis

Autor: Carleton M. Sherman, Shashikant Srivastava, Thearith Koeuth, Tawanda Gumbo, Jotam G. Pasipanodya, Prithvi Raj, Edward K. Wakeland, Devyani Deshpande, Gesham Magombedze

Publikováno v: Antimicrobial Agents and Chemotherapy

Linezolid has an excellent sterilizing effect in tuberculosis patients but high adverse event rates. The dose that would maximize efficacy and minimize toxicity is unknown. We performed linezolid dose-effect and dose-scheduling studies in the hollow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cea57ebfb6c89c75e6effb0058fd05
http://europepmc.org/articles/PMC5527615

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Amikacin Pharmacokinetics/Pharmacodynamics in a Novel Hollow-Fiber Mycobacterium abscessus Disease Model

Autor: Jakko van Ingen, Dick van Soolingen, Carleton M. Sherman, Jotam G. Pasipanodya, Tawanda Gumbo, Beatriz E. Ferro, Shashikant Srivastava, Johan W. Mouton, Devyani Deshpande

Publikováno v: Antimicrobial Agents and Chemotherapy, 60, 3, pp. 1242-8
Antimicrobial Agents and Chemotherapy, 60, 1242-8
Antimicrobial Agents & Chemotherapy, 60(3), 1242-1248. American Society for Microbiology

The treatment of pulmonary Mycobacterium abscessus disease is associated with very high failure rates and easily acquired drug resistance. Amikacin is the key drug in treatment regimens, but the optimal doses are unknown. No good preclinical model ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d2eb24b6e45a65fc122c82df98c09c
https://hdl.handle.net/2066/171149

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Pharmacokinetic Mismatch Does Not Lead to Emergence of Isoniazid- or Rifampin-Resistant Mycobacterium tuberculosis but to Better Antimicrobial Effect: a New Paradigm for Antituberculosis Drug Scheduling

Autor: Shashikant Srivastava, Richard D. Leff, Claudia Meek, Tawanda Gumbo, Carleton M. Sherman

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:5085-5089

Multidrug resistant-tuberculosis is a pressing problem. One of the major mechanisms proposed to lead to the emergence of drug resistance is pharmacokinetic mismatch. Stated as a falsifiable hypothesis, the greater the pharmacokinetic mismatch between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55621f767190ac3273deadf11b7d1770
https://doi.org/10.1128/aac.00269-11

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A New Aleiodes (=Tetrasphaeropyx) (=A. pilosus Group), with a Host Record from Missouri, U.S.A., Biological Remarks, and Previous Type Depository Corrections

Autor: Carleton M. Sherman, Joseph C. Fortier

Publikováno v: Entomological News. 119:445-453

Aleiodes reisi, a new species of parasitoid wasp with an enlarged, heavily sculptured, carapace-like metasomal tergite IV was reared from the geometrid Macaraia multilineata Packard collected from Eastern Red Cedar (Juniperus virginiana L) in Missour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97087cee4001848e5e6f516568d4bde2
https://doi.org/10.3157/0013-872x-119.5.445

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Rapid drug tolerance and dramatic sterilizing effect of moxifloxacin monotherapy in a novel hollow-fiber model of intracellular Mycobacterium kansasii disease

Autor: Richard D. Leff, Tawanda Gumbo, Shashikant Srivastava, Claudia Meek, Jotam G. Pasipanodya, Carleton M. Sherman

Publikováno v: Antimicrobial agents and chemotherapy. 59(4)

Mycobacterium kansasii is the second most common mycobacterial cause of lung disease. Standard treatment consists of rifampin, isoniazid, and ethambutol for at least 12 months after negative sputum. Thus, shorter-duration therapies are needed. Moxifl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bec56fa581476260b5f2916db7ccbf
https://pubmed.ncbi.nlm.nih.gov/25645830

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Cellular resistance to oxidative stress is accompanied by resistance to cisplatin: The significance of increased catalase activity and total glutathione in hydrogen peroxide-resistant fibroblasts

Autor: Douglas R. Spitz, Phillips Jw, Li Gc, D.T. Adams, Carleton M. Sherman, Deen Df

Publikováno v: Journal of Cellular Physiology. 156:72-79

Studies designed to better understand the involvement of cellular resistance to oxidative stress in mechanisms of cellular resistance to cisplatin were undertaken using H2O2-resistant variants of the HA 1 Chinese hamster fibroblast cell line. H2O2-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b324f5edee1f212621afe00ead798d74
https://doi.org/10.1002/jcp.1041560111

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Efflux-pump-derived multiple drug resistance to ethambutol monotherapy in Mycobacterium tuberculosis and the pharmacokinetics and pharmacodynamics of ethambutol

Autor: Claudia Meek, Tawanda Gumbo, Sandirai Musuka, Shashikant Srivastava, Richard D. Leff, Carleton M. Sherman

Publikováno v: The Journal of infectious diseases. 201(8)

Ethambutol is used for the treatment of tuberculosis in cases where there is isoniazid resistance. We examined the emergence of drug resistance to ethambutol monotherapy in pharmacokinetic-pharmacodynamic studies of a hollow-fiber system.Dose-effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fa01d2d044d14a1bc15374bafeb1c5
https://pubmed.ncbi.nlm.nih.gov/20210628

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