Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Carles FABREGAT"'
Autor:
Margherita Rimini, Carles Fabregat-Franco, Valentina Burgio, Sara Lonardi, Monica Niger, Mario Scartozzi, Ilario Giovanni Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract IDH1-mutated cholangiocarcinomas (CCAs) are an interesting group of neoplasia with particular behavior and therapeutic implications. The aim of the present work is to highlight the differences characterizing IDH1m and IDH1wt CCAs in terms of
Externí odkaz:
https://doaj.org/article/49008ad5b7a4484585f1c9926745098f
Autor:
Margherita Rimini, Carles Fabregat-Franco, Mara Persano, Valentina Burgio, Francesca Bergamo, Monica Niger, Mario Scartozzi, Ilario Giovanni Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Publikováno v:
Targeted Oncology. 18:139-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dd0a0ff138ea097b1150a0c8e2737c
https://doi.org/10.1007/s11523-022-00933-7
https://doi.org/10.1007/s11523-022-00933-7
Autor:
Margherita Rimini, Eleonora Loi, Carles Fabregat-Franco, Valentina Burgio, Sara Lonardi, Monica Niger, Mario Scartozzi, Ilario G. Raposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Mario Rizzato, Federico Nichetti, Eleonora Lai, Alessandro Cappetta, Teresa Macarulla, Matteo Fassan, Filippo De Braud, Andrea Pretta, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Patrizia Zavattari, Andrea Casadei-Gardini
Publikováno v:
European Journal of Cancer. 175:299-310
IDH1-mutated intrahepatic cholangiocarcinomas (IDH1m iCCAs) could be treated with anti-IDH1 drugs, although the high heterogeneity in this class of tumours could limit treatment efficacy.We selected 125 IDH1m iCCAs that were treated as resectable, lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d869e3d71a0efdccee4c287b69a11a13
https://doi.org/10.1016/j.ejca.2022.08.026
https://doi.org/10.1016/j.ejca.2022.08.026
Autor:
Margherita Rimini, Teresa Macarulla, Valentina Burgio, Sara Lonardi, Monica Niger, Mario Scartozzi, Ilario G. Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Floriana Nappo, Federico Nichetti, Eleonora Lai, Martina Valgiusti, Alessandro Cappetta, Carles Fabregat-Franco, Matteo Fassan, Filippo De Braud, Marco Puzzoni, Giovanni L. Frassineti, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Publikováno v:
European Journal of Cancer. 171:232-241
Biliary tract cancers are rare malignancies with a poor prognosis and scarce therapeutic strategies. The significance of BRCAness in this setting is already unknown.Tissue specimens of BTC patients treated with platinum-based chemotherapy have been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d864b18b61a20d7788fec000dd64d79
https://doi.org/10.1016/j.ejca.2022.05.004
https://doi.org/10.1016/j.ejca.2022.05.004
Autor:
Tian V. Tian, Teresa Macarulla, Sandra Peiró, Josep Tabernero, Joaquín Arribas, Violeta Serra, Marta Melé, Ana Vivancos, Paolo G. Nuciforo, Josep M. Miquel, Óscar J. Pozo, Francis J. Giles, Noemí Haro, Cristina Bernadó-Morales, Enrique J. Arenas, Marta Escorihuela, Carmen Escudero-Iriarte, Carles Fabregat-Franco, Florian Castet, Mariana Yáñez-Bartolomé, Jessica Querol, Joan Frigola, Cindy Neuzillet, Anthony Turpin, Maria Vila-Casadesús, Cristina Molina, Alba Llop-Guevara, Núria Lupión-Garcia, Winona Oliveros, Helena Verdaguer, Queralt Serra-Camprubí
Information of patients underwent the biopsy procedures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c01603d143aabc99513a7d81963a854
https://doi.org/10.1158/1078-0432.22488986.v1
https://doi.org/10.1158/1078-0432.22488986.v1
Autor:
Tian V. Tian, Teresa Macarulla, Sandra Peiró, Josep Tabernero, Joaquín Arribas, Violeta Serra, Marta Melé, Ana Vivancos, Paolo G. Nuciforo, Josep M. Miquel, Óscar J. Pozo, Francis J. Giles, Noemí Haro, Cristina Bernadó-Morales, Enrique J. Arenas, Marta Escorihuela, Carmen Escudero-Iriarte, Carles Fabregat-Franco, Florian Castet, Mariana Yáñez-Bartolomé, Jessica Querol, Joan Frigola, Cindy Neuzillet, Anthony Turpin, Maria Vila-Casadesús, Cristina Molina, Alba Llop-Guevara, Núria Lupión-Garcia, Winona Oliveros, Helena Verdaguer, Queralt Serra-Camprubí
Evaluation of RAD51 scores in CCA_PDXs and CCA patients. (A) RAD51 scores of CCA_PDXs and their matched originating biopsy samples. (B) RAD51 scores evaluated in PDX85 (IDH1mut) treated as for Figure 4C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a82f369826c036fa8fd57e381e4cec
https://doi.org/10.1158/1078-0432.22488992.v1
https://doi.org/10.1158/1078-0432.22488992.v1
Autor:
Tian V. Tian, Teresa Macarulla, Sandra Peiró, Josep Tabernero, Joaquín Arribas, Violeta Serra, Marta Melé, Ana Vivancos, Paolo G. Nuciforo, Josep M. Miquel, Óscar J. Pozo, Francis J. Giles, Noemí Haro, Cristina Bernadó-Morales, Enrique J. Arenas, Marta Escorihuela, Carmen Escudero-Iriarte, Carles Fabregat-Franco, Florian Castet, Mariana Yáñez-Bartolomé, Jessica Querol, Joan Frigola, Cindy Neuzillet, Anthony Turpin, Maria Vila-Casadesús, Cristina Molina, Alba Llop-Guevara, Núria Lupión-Garcia, Winona Oliveros, Helena Verdaguer, Queralt Serra-Camprubí
Purpose:Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffad5473b6ac95e115576bc8c4bb844
https://doi.org/10.1158/1078-0432.c.6532853.v1
https://doi.org/10.1158/1078-0432.c.6532853.v1
Autor:
Queralt Serra-Camprubí, Helena Verdaguer, Winona Oliveros, Núria Lupión-Garcia, Alba Llop-Guevara, Cristina Molina, Maria Vila-Casadesús, Anthony Turpin, Cindy Neuzillet, Joan Frigola, Jessica Querol, Mariana Yáñez-Bartolomé, Florian Castet, Carles Fabregat-Franco, Carmen Escudero-Iriarte, Marta Escorihuela, Enrique J. Arenas, Cristina Bernadó-Morales, Noemí Haro, Francis J. Giles, Óscar J. Pozo, Josep M. Miquel, Paolo G. Nuciforo, Ana Vivancos, Marta Melé, Violeta Serra, Joaquín Arribas, Josep Tabernero, Sandra Peiró, Teresa Macarulla, Tian V. Tian
Publikováno v:
Scientia
Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A/B, BAP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4099d028372bc61fdb08354764a3e7a4
https://pubmed.ncbi.nlm.nih.gov/36374558
https://pubmed.ncbi.nlm.nih.gov/36374558
Autor:
Carles Fabregat-Franco, Changhoon Yoo, Bruno Sangro, Camilla Qvortrup, Hyung-Don Kim, Teresa Macarulla, Mariano Ponz-Sarvisé, Chia-Chi Lin, Do-Youn Oh, Thomas Yau, Juliana Bessa, Petra C. Schwalie, Steffen Dettling, Ramona Schlenker, Natascha Riede, Elia Hall, Felix Lichtenegger, Nicole Kratochwil, Thomas Pöschinger, Zhiwen Jiang, Tianyi Jiang, Christina Godfried Sie, Audrey Yeo Te-Ying, Christina Schiff, Sabine Hoves, Michael Cannarile
Publikováno v:
Cancer Research. 83:2342-2342
Background: It is hypothesized that TLR7 agonists reprogram myeloid cells in the TME, which may lead to activation of antitumor CD8 T effector cells and subsequently tumor cell death. The orally available TLR7 agonist prodrug RO7119929 is mainly conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575178c144cf7c416c0b8b1675a1d0f0
https://doi.org/10.1158/1538-7445.am2023-2342
https://doi.org/10.1158/1538-7445.am2023-2342
Autor:
Margherita Rimini, Teresa Macarulla, Valentina Burgio, Sara Lonardi, Monica Niger, Mario Scartozzi, Ilario G. Rapposelli, Giuseppe Aprile, Francesca Ratti, Federica Pedica, Helena Verdaguer, Floriana Nappo, Federico Nichetti, Eleonora Lai, Martina Valgiusti, Alessandro Cappetta, Carles Fabregat-Franco, Matteo Fassan, Filippo De Braud, Marco Puzzoni, Giovanni L. Frassineti, Francesca Simionato, Francesco De Cobelli, Luca Aldrighetti, Lorenzo Fornaro, Stefano Cascinu, Andrea Casadei-Gardini
Publikováno v:
European Journal of Cancer. 177:206-207
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b941b2a9a294196d210c5622470273c8
https://doi.org/10.1016/j.ejca.2022.09.019
https://doi.org/10.1016/j.ejca.2022.09.019