Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae.

Autor: Jen-Feng Lai, Carlene L Zindl, Lynn B Duffy, T Prescott Atkinson, Yong Woo Jung, Nico van Rooijen, Ken B Waites, Duncan C Krause, David D Chaplin

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14417 (2010)

Mycoplasma pneumoniae (Mp), a common cause of pneumonia, is associated with asthma; however, the mechanisms underlying this association remain unclear. We investigated the cellular immune response to Mp in mice. Intranasal inoculation with Mp elicite

Externí odkaz: https://doaj.org/article/03cff92743aa40d28504c5fac909abc3

TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity

Autor: Trenton R. Schoeb, Min Gao, Steven Witte, Casey T. Weaver, Robin D. Hatton, Stacey N. Harbour, Gareth W. Jones, Daniel DiToro, Simon Arnett Jones, Carlene L. Zindl

Publikováno v: Harbour, S N, Ditoro, D F, Witte, S J, Zindl, C L, Gao, M, Schoeb, T R, Jones, G W, Jones, S A, Hatton, R D & Weaver, C T 2020, ' TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity ', Science Immunology, vol. 5, no. 49, pp. eaaw2262 . https://doi.org/10.1126/sciimmunol.aaw2262

Acting in concert with TGF-β, interleukin-6 (IL-6) signaling induces T helper 17 (TH17) cell development by programming TH17-related genes via signal transducers and activators of transcription 3 (STAT3). A role for IL-6 signaling beyond the inducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4870736a8c82b2f69caac28662df31
https://research-information.bris.ac.uk/ws/files/243826821/aaw2262_CombinedPDF.pdf

Citrobacter rodentium: a model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunity

Autor: Daniel J. Silberger, Casey T. Weaver, Carlene L. Zindl

Publikováno v: Mucosal Immunology. 10:1108-1117

Citrobacter rodentium is a natural murine intestinal pathogen that shares a core set of virulence factors with the related human pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC). C. rodentium is now the most wid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17253885964d09e690bef3e0bd0058a1
https://doi.org/10.1038/mi.2017.47

T

Autor: Stacey N, Harbour, Daniel F, DiToro, Steven J, Witte, Carlene L, Zindl, Min, Gao, Trenton R, Schoeb, Gareth W, Jones, Simon A, Jones, Robin D, Hatton, Casey T, Weaver

Publikováno v: Sci Immunol

Acting in concert with TGF-β, IL-6 signaling induces Th17 cell development by programming Th17-related genes via STAT3. A role for IL-6 signaling beyond the inductive phase of Th17 cell development has not been defined, as IL-23 signaling downstream

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::696f0bf818689221f7ba3bc680e6f0c2
https://pubmed.ncbi.nlm.nih.gov/32680955

IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription

Autor: Anand Balasubramani, Carlene L. Zindl, Ranjan Sen, Robin D. Hatton, Sarah K. Whitley, Casey T. Weaver, Gregory E. Crawford, Nathaniel M. Weathington, Yoichiro Shibata

Interleukin (IL)-1β plays a critical role in IL-6β– and transforming growth factor β (TGFβ)–initiated Th17 differentiation and induction of Th17-mediated autoimmunity. However, the means by which IL-1 regulates various aspects of Th17 develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780dc73a80637263b555037d48b25e7d
https://europepmc.org/articles/PMC6187645/