Comprehensive evaluation of smoking exposures and their interactions on DNA methylationResearch in context

Autor: Thanh T. Hoang, Yunsung Lee, Daniel L. McCartney, Elin T.G. Kersten, Christian M. Page, Paige M. Hulls, Mikyeong Lee, Rosie M. Walker, Charles E. Breeze, Brian D. Bennett, Adam B. Burkholder, James Ward, Anne Lise Brantsæter, Ida H. Caspersen, Alison A. Motsinger-Reif, Marie Richards, Julie D. White, Shanshan Zhao, Rebecca C. Richmond, Maria C. Magnus, Gerard H. Koppelman, Kathryn L. Evans, Riccardo E. Marioni, Siri E. Håberg, Stephanie J. London, Bastiaan Heijmans, Peter ’t Hoen, Joyce van Meurs, Rick Jansen, Lude Franke, Dorret Boomsma, René Pool, Jenny van Dongen, Jouke Hottenga, Marleen van Greevenbroek, Coen Stehouwer, Carla van der Kallen, Casper Schalkwijk, Cisca Wijmenga, Sasha Zhernakova, Ettje Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana Van Heemst, Jan Veldink, Leonard van den Berg, Cornelia van Duijn, Bert Hofman, Aaron Isaacs, André Uitterlinden, P. Mila Jhamai, Michael Verbiest, H. Eka Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha Zhernakova, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Bonder, Freerk van Dijk, Wibowo Arindrarto, Szymon Kielbasa, Morris Swertz, Erik van Zwet

Publikováno v: EBioMedicine, Vol 100, Iss , Pp 104956- (2024)

Summary: Background: Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (

Externí odkaz: https://doaj.org/article/3985b627485b4ff999b2ec073dfaf4e4

P151 Microvascular Dysfunction is Associated with Impaired Beta-cell Function: The Maastricht Study

Autor: Wenjie Li, Alfons Houben, Tos Berendschot, Carroll Webers, Abraham Kroon, Marleen van Greevenbroek, Carla van der Kallen, Ronald Henry, Simone Sep, Pieter Dagnelie, Nicolaas Schaper, Simone Eussen, Casper Schalkwijk, Miranda Schram, Coen Stehouwer

Publikováno v: Artery Research, Vol 25, Iss S1, Pp S188-S188 (2020)

Abstract Background The pathophysiological mechanism underlying beta-cell dysfunction in type 2 diabetes (T2D) is not fully understood. Recent animal studies suggest that microvascular dysfunction (MVD) may lead to insufficient delivery of oxygen and

Externí odkaz: https://doaj.org/article/a4118b97044e4cb6affa5102de05e21d

3.1 PREDIABETES IS ASSOCIATED WITH IMPAIRED RETINAL VASODILATION: THE MAASTRICHT STUDY

Autor: Ben Sörensen, Boy Houben, Tos Berendschot, Jan Schouten, Bram Kroon, Carla van der Kallen, Ronald Henry, Annemarie Koster, Pieter Dagnelie, Nicolaas Schaper, Miranda Schram, Coen Stehouwer

Publikováno v: Artery Research, Vol 12 (2015)

Aim: Type 2 diabetes (DM2) causes microvascular dysfunction (MVD). In addition, MVD can contribute to insulin resistance, predisposing to DM2. This hypothesis predicts that MVD should be present in impaired glucose metabolism (IGM; prediabetes). Howe

Externí odkaz: https://doaj.org/article/95a6baa2ec894ef4994aa4836d9cac1a

(Pre)Diabetes, Greater Glycemia, and Greater Daily Glucose Variability are Associated with Lower Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration and Precursor of Diabetic Retinopathy– The Maastricht Study

Autor: Anke Wesselius, Jan S. A. G. Schouten, Marleen J. van Greevenbroek, Miranda T. Schram, Coen D.A. Stehouwer, Nicolaas C. Schaper, Frank Ct van der Heide, Carroll A.B. Webers, Yuri D. Foreman, Martijn C. G. J. Brouwers, S. Eussen, Carla van der kallen, Abraham A. Kroon, Iris Franken, Ronald M. A. Henry, Tos T. J. M. Berendschot, Casper G. Schalkwijk, Pieter C. Dagnelie

ObjectiveDiabetic retinopathy in type 2 diabetes is preceded by retinal nerve fiber layer (RNFL) thinning, an index of neurodegeneration. We investigated whether glucose metabolism status (GMS), measures of glycemia, and daily glucose variability (GV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5772856bbf51c85afcff9633113e4021
https://doi.org/10.21203/rs.3.rs-970767/v1

GENERALISED MICROVASCULAR DYSFUNCTION IS NONLINEARLY ASSOCIATED WITH HIGHER EXERCISE BLOOD PRESSURE – THE MAASTRICHT STUDY

Autor: Tan Lai Zhou, Abraham Kroon, Alfonsius Houben, Jacobus Jansen, Tos Berendschot, Caroll Webers, Carla Van der Kallen, Miranda Schram, Coen Stehouwer

Publikováno v: Journal of Hypertension. 40:e12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9b03a4cdd7131ae9ce35f698305babb
https://doi.org/10.1097/01.hjh.0000835396.37269.91