Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carla Suto"'
Autor:
Anthony D. Sercel, Carla Suto, H. D. Hollis Showalter, Judith Leopold, William L. Elliott, Wilbur R. Leopold, R. Thomas Winters
Publikováno v:
ChemInform. 45
The synthesis of a small series of 2-nitroimidazoles in which the β-amino alcohol side chain was amidated with a range of alkylating/acylating functionality is described. Synthetic methodologies were developed that generally provided for selective N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66731221eaa3c6068ffeefa9fe03f39
https://doi.org/10.1002/chin.201432146
https://doi.org/10.1002/chin.201432146
Autor:
H. D. Hollis Showalter, Anthony D. Sercel, R. Thomas Winters, William L. Elliott, Judith Leopold, Carla Suto, Wilbur R. Leopold
Publikováno v:
Chemicalpharmaceutical bulletin. 62(3)
The synthesis of a small series of 2-nitroimidazoles in which the β-amino alcohol side chain was amidated with a range of alkylating/acylating functionality is described. Synthetic methodologies were developed that generally provided for selective N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9823e138c2f070822c542614ddadfedd
https://pubmed.ncbi.nlm.nih.gov/24583786
https://pubmed.ncbi.nlm.nih.gov/24583786
Autor:
Mark A. Varney, Carla Suto
Publikováno v:
Drug Discovery Today. 5:20-26
Recent research in the area of metabotropic glutamate receptors suggests that subtype-selective modulators of individual family members could be promising candidates for a variety of nervous system disorders including pain, neurodegeneration and nume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e248b86e86a5f9185858177c45a62fb4
https://doi.org/10.1016/s1359-6446(00)01499-9
https://doi.org/10.1016/s1359-6446(00)01499-9
Autor:
Tadimeti S. Rao, P. Adams, Jean Michel Vernier, Lucia Correa, Emily M. Santori, Carla Suto, R. T. Reid, Aida I. Sacaan
Publikováno v:
Brain research. 981(1-2)
SIB-1553A ((+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol HCl) is a neuronal nicotinic acetylcholine receptor (nAChR) ligand which displaced the binding of [3H]nicotine (NIC) to the rat brain nAChRs with an IC(50) value of 110 nM with no appre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3d55d2446687acd128a7d0d2920ff7
https://pubmed.ncbi.nlm.nih.gov/12885429
https://pubmed.ncbi.nlm.nih.gov/12885429
Autor:
Bradley P. Feuston, C. Bayly, Kurtis Berry, Richard Peltier, Jason Cassaday, Carla Suto, Chris Culberson, James Inglese, Berta Strulovici, Nicholas D. P. Cosford, Mark A. Varney, Leo Bleicher, Peter Hodder
Publikováno v:
Analytical biochemistry. 313(2)
Antagonists to the human metabotropic glutamate receptor subtype 5 a (mGluR 5a ) have been implicated as potential therapeutics for the treatment of a variety of nervous system disorders, including pain, anxiety, and Parkinson’s disease. To discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5128daffa6d5aaf088801f15193758e5
https://pubmed.ncbi.nlm.nih.gov/12605861
https://pubmed.ncbi.nlm.nih.gov/12605861
Autor:
Arnold Ow, Mark J. Suto, Lynn J. Ransone, Carla Suto, Anthony M. Manning, Moorthy S. S. Palanki, Paul Erdman, Cheryl Spooner
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(15)
In an effort to identify novel inhibitors of AP-1 and NF-κB mediated transcriptional activation, several analogues of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)pyrimidine-5-carboxylate ( 1 ) were synthesized and tested in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6946340ff06f645111032817c29b3f37
https://pubmed.ncbi.nlm.nih.gov/10937715
https://pubmed.ncbi.nlm.nih.gov/10937715
Autor:
Carla Suto, Tadimeti S. Rao, Ian A. McDonald, Robert Siegel, Jean-Michel Vernier, G. Kenneth Lloyd, Laura E. Chavez-Noriega, Nicholas D. P. Cosford, Leo Bleicher, Mark S. Washburn
Publikováno v:
Pharmaceutica acta Helvetiae. 74(2-3)
Neuronal nicotinic acetylcholine receptors (nAChRs) are a class of ion channels with significant potential as molecular targets for the design of drugs to treat a variety of CNS disorders. The discovery that neuronal nAChRs are further subdivided int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a07d1745fce7ead20c149103f9e299
https://pubmed.ncbi.nlm.nih.gov/10812948
https://pubmed.ncbi.nlm.nih.gov/10812948
Autor:
Nicholas D.P. Cosford, Leo Bleicher, Jean-Michel Vernier, Laura Chavez-Noriega, Tadimeti S. Rao, Robert S. Siegel, Carla Suto, Mark Washburn, G. Kenneth Lloyd, Ian A. McDonald
Publikováno v:
Receptor Chemistry towards the Third Millennium, Proceedings of the 12th Camerino-Noordwijkerhout Symposium ISBN: 9780444504241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e953eae3f441f00b912fb10c7c369118
https://doi.org/10.1016/s0165-7208(00)80008-2
https://doi.org/10.1016/s0165-7208(00)80008-2
Autor:
Nicholas D. P. Cosford, G. Barker, R. T. Reid, Laura E. Chavez-Noriega, Frederique Menzaghi, Ian A. McDonald, G. K. Lloyd, Bruno Bontempi, H. Holsenback, Tadimeti S. Rao, Jean-Michel Vernier, Leo Bleicher, H. El-Abdellaoui, Mark S. Washburn, Carla Suto, Aida I. Sacaan
Publikováno v:
Journal of medicinal chemistry. 42(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8d25bd146174da4b0ead6db51bc9f9
https://pubmed.ncbi.nlm.nih.gov/10346920
https://pubmed.ncbi.nlm.nih.gov/10346920
Autor:
Tadimeti S. Rao, G. Kenneth Lloyd, Jean-Michel Vernier, Nicholas D. P. Cosford, Laura E. Chavez-Noriega, Frédérique Menzaghi, Arturo Urrutia, Carla Suto, Heather Holsenback, Aida I. Sacaan, Ian A. McDonald, Mark S. Washburn, Jeffrey P. Whitten, R. T. Reid
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(16)
A series of conformationally restricted analogues of nicotine has been synthesized and evaluated as agonists of neuronal acetylcholine receptors. Compound 2 (SIB-1663), which selectively activated human recombinant alpha 2 beta 4 and alpha 4 beta 4 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2178f568ace913b70d0f413355174731
https://pubmed.ncbi.nlm.nih.gov/9873508
https://pubmed.ncbi.nlm.nih.gov/9873508