Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Carla Sens"'
Autor:
Carla Sens-Albert, Sabrina Weisenburger, Beatrix C. König, Silas F. Melcher, Ulrike A. M. Scheyhing, Karin Rollet, Philippe Lluel, Egon Koch, Martin D. Lehner, Martin C. Michel
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Phytotherapeutics, particularly extracts from Sabal serrulata (saw palmetto) fruit or Urtica dioica (stinging nettle) root, are popular for the treatment of male lower urinary symptoms in many countries, but their mechanism of action is
Externí odkaz:
https://doaj.org/article/f65ae83f53f8473f891ec9ba2c6b715b
Autor:
Eva Altrock, Carla Sens-Albert, Franziska Hofmann, Vladimir Riabov, Nanni Schmitt, Qingyu Xu, Johann-Christoph Jann, Felicitas Rapp, Laurenz Steiner, Alexander Streuer, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Melda Göl, Ali Darwich, Patrick Wuchter, Georgia Metzgeroth, Mohamad Jawhar, Wolf-Karsten Hofmann, Daniel Nowak
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Background Robust and reliable in vitro and in vivo models of primary cells are necessary to study the pathomechanisms of Myelodysplastic Neoplasms (MDS) and identify novel therapeutic strategies. MDS-derived hematopoietic stem and progenito
Externí odkaz:
https://doaj.org/article/3d993a6d3dfe43489fb55296d3d2a803
Autor:
Qingyu Xu, Alexander Streuer, Johann-Christoph Jann, Eva Altrock, Nanni Schmitt, Johanna Flach, Carla Sens-Albert, Felicitas Rapp, Julia Wolf, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Mariia Kuzina, Ahmed Jawhar, Ali Darwich, Cleo-Aron Weis, Alexander Marx, Patrick Wuchter, Victor Costina, Evelyn Jäger, Elena Sperk, Michael Neumaier, Alice Fabarius, Georgia Metzgeroth, Florian Nolte, Laurenz Steiner, Pavel A. Levkin, Mohamad Jawhar, Wolf-Karsten Hofmann, Vladimir Riabov, Daniel Nowak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Hypomethylating agents, such as 5-Azacytidine (5-AZA), are standard of care for patients with myelodysplastic and myeloid malignancies, however response rates are limited and risk of relapses high. Here the authors show that inhibition of lysyl oxida
Externí odkaz:
https://doaj.org/article/91b523f59ac547d99572fb13b46e1d2f
Autor:
Alexandra Sporkova, Taslima Nahar, Mingsi Cao, Subhajit Ghosh, Carla Sens-Albert, Prisca Amayi Patricia Friede, Anika Nagel, Jaafar Al-Hasani, Markus Hecker
Publikováno v:
Cells, Vol 12, Iss 18, p 2315 (2023)
In arteries and arterioles, a chronic increase in blood pressure raises wall tension. This continuous biomechanical strain causes a change in gene expression in vascular smooth muscle cells (VSMCs) that may lead to pathological changes. Here we have
Externí odkaz:
https://doaj.org/article/0678f737277343429382de7a30fecb08
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 385 (2020)
The regulation of the differentiation of the bone-forming cells, the osteoblasts, is complex. Many signaling pathways converge on the master regulator of osteoblast differentiation Runx2. The role of molecules that integrate several signaling pathway
Externí odkaz:
https://doaj.org/article/bbd3f49eae0248f090b9e9bb7fda6a55
Autor:
Anja von Au, Matthaeus Vasel, Sabrina Kraft, Carla Sens, Norman Hackl, Alexander Marx, Philipp Stroebel, Jörg Hennenlotter, Tilman Todenhöfer, Arnulf Stenzl, Sarah Schott, Hans-Peter Sinn, Antoinette Wetterwald, Justo Lorenzo Bermejo, Marco G Cecchini, Inaam A Nakchbandi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 8, Pp 925-938 (2013)
Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation. The relative contribution of local and circulating fibronectin to blood vessel formation in vivo remains
Externí odkaz:
https://doaj.org/article/1bd397fdc23c48fda9dccebf2d503938
Autor:
Stephanie Rossnagl, Eva Altrock, Carla Sens, Sabrina Kraft, Katrin Rau, Michael D Milsom, Thomas Giese, Yvonne Samstag, Inaam A Nakchbandi
Publikováno v:
PLoS Biology, Vol 14, Iss 9, p e1002562 (2016)
Osteoblasts lining the inner surface of bone support hematopoietic stem cell differentiation by virtue of proximity to the bone marrow. The osteoblasts also modify their own differentiation by producing various isoforms of fibronectin (FN). Despite e
Externí odkaz:
https://doaj.org/article/4f2a5c63200e4bb7acb0cf958ac76cb6
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28181 (2011)
Fibrotic tissue in the liver is mainly composed of collagen. Fibronectin, which is also present in fibrotic matrices, is required for collagen matrix assembly in vitro. It also modulates the amount of growth factors and their release from the matrix.
Externí odkaz:
https://doaj.org/article/ec15ff925fd9489cb51764db7b41a69e
Autor:
Eva Altrock, Carla Sens-Albert, Johann-Christoph Jann, Johanna Flach, Vladimir Riabov, Nanni Schmitt, Qingyu Xu, Arwin Mehralivand, Anna Hecht, Laurenz Steiner, Alexander Streuer, Verena Nowak, Julia Obländer, Nadine Weimer, Iris Palme, Ahmed Jawhar, Cleo-Aron Weis, Vanessa Weyer, Florian Nolte, Mohamad Jawhar, Georgia Metzgeroth, Alexander Marx, Christoph Groden, Wolf-Karsten Hofmann, Daniel Nowak
Publikováno v:
Experimental Hematology. 107:38-50
Patient-derived xenograft (PDX) models have emerged as versatile preclinical platforms for investigation of functional pathomechanisms in myelodysplastic syndromes (MDS) and other myeloid neoplasms. However, despite increasingly improved methodology,
Autor:
Qingyu Xu, Alexander Streuer, Johann-Christoph Jann, Eva Altrock, Nanni Schmitt, Johanna Flach, Carla Sens-Albert, Felicitas Rapp, Julia Wolf, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Ahmed Jawhar, Ali Darwich, Cleo-Aron Weis, Alexander Marx, Patrick Wuchter, Victor Costina, Evelyn Jäger, Elena Sperk, Michael Neumaier, Alice Fabarius, Georgia Metzgeroth, Florian Nolte, Laurenz Steiner, Mohamad Jawhar, Wolf-Karsten Hofmann, Vladimir Riabov, Daniel Nowak
Publikováno v:
Blood. 140:3054-3055