Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Carla S. Verissimo"'
Autor:
Lidwien P. Smabers, Emerens Wensink, Carla S. Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, Maarten A. Huismans, Celia Higuera Barón, Mayke Doorn, Liselot B. Valkenburg-van Iersel, Geert A. Cirkel, Anneta Brousali, René Overmeer, Miriam Koopman, Manon N. Braat, Bas Penning de Vries, Sjoerd G. Elias, Robert G. Vries, Onno Kranenburg, Sylvia F. Boj, Jeanine M. Roodhart
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatmen
Externí odkaz:
https://doaj.org/article/42108938a8624e94af5a5620f30c1743
Autor:
Sander Mertens, Maarten A. Huismans, Carla S. Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F. Boj, Hans Clevers, Jeanine M.L. Roodhart, Johannes L. Bos, Hugo J.G. Snippert
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112324- (2023)
Summary: Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify hidden vulnerabilities with
Externí odkaz:
https://doaj.org/article/90d447bcda174d4aba2b71aaf83d4fbd
Autor:
Scott A Jelinsky, Merel Derksen, Eric Bauman, Carla S Verissimo, Wies T M van Dooremalen, Jamie Lee Roos, Celia Higuera Barón, Celia Caballero-Franco, Bryce G Johnson, Michelle G Rooks, Johanna Pott, Bas Oldenburg, Robert G J Vries, Sylvia F Boj, Marion T Kasaian, Farzin Pourfarzad, Charles V Rosadini
Publikováno v:
Inflammatory bowel diseases.
Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by inconsistencies with differentiation and functional characterization. We profiled molecular and cellu
Autor:
Carla S Verissimo, René M Overmeer, Bas Ponsioen, Jarno Drost, Sander Mertens, Ingrid Verlaan-Klink, Bastiaan van Gerwen, Marieke van der Ven, Marc van de Wetering, David A Egan, René Bernards, Hans Clevers, Johannes L Bos, Hugo J Snippert
Publikováno v:
eLife, Vol 5 (2016)
Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and
Externí odkaz:
https://doaj.org/article/7501d8e3fc1b4a42aa7676d2bb0a2f09
Autor:
Carla S. Verissimo, Lidwien Smabers, Emerens Wensink, Esmee Koedoot, Katerina-Chara Pitsa, Mayke Doorn, Inez van Weersch, Hamdy Warda, Celia Higuera Barón, Gerben ten Hag, Robert G. Vries, Jeanine Roodhart, Sylvia F. Boj
Publikováno v:
Cancer Research. 83:151-151
Patient-derived organoids (PDOs) are increasingly adopted in preclinical research. PDOs, or HUB Organoids®, are directly established from patient tissue, faithfully recapitulate patient disease, and effectively bridge the gap between the lab and the
Autor:
Carla S. Verissimo, Lidwien Smabers, Emerens Wensink, Esmee Koedoot, Maarten Huismans, Celia Higuera Barón, Ricardo Korporaal, Emma Teal, Katerina-Chara Pitsa, Edwin van Oosten, Roshni Nair, Liselot Valkenburg, Geert Cirkel, Anneta Brousali, Jorieke Salij, René Overmeer, Manon Braat, Sjoerd Elias, Robert Vries, Onno Kranenburg, Miriam Koopman, Sylvia F. Boj, Jeanine Roodhart
Publikováno v:
Cancer Research. 82:4112-4112
Colorectal cancer (CRC) is the third leading cause of cancer and cancer-related death. A large fraction of the CRC patients diagnosed with de novo metastatic disease do not benefit from the standard of care but still experience substantial side effec
Autor:
Hans Clevers, Esmée J. van Vliet, Anne C. Rios, Jane E. Visvader, Sylvia F. Boj, Carol Piani, Heggert G Rebel, Oded Kopper, Johanna F. Dekkers, Carla S Verissimo, Jennifer M. Rosenbluth, Norman Sachs, Joan S. Brugge, Ellen J. Wehrens
Publikováno v:
Nat Protoc
Nature Protocols, 16(4), 1936-1965. Nature Publishing Group
Nature Protocols, 16(4), 1936-1965. Nature Publishing Group
Organoid technology has revolutionized the study of human organ development, disease and therapy response tailored to the individual. Although detailed protocols are available for the generation and long-term propagation of human organoids from vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bc869d4deafc27f9ee422c5e8cc7bf
https://europepmc.org/articles/PMC8221035/
https://europepmc.org/articles/PMC8221035/
Autor:
Hugo J. Snippert, Marieke van de Ven, Natalie Proost, René M. Overmeer, Carla S Verissimo, Hans Clevers, Johannes L. Bos, Jeanine M.L. Roodhart, Olaf van Tellingen, Harry Begthel, Jeanine Roodhart, Maarten A. Huismans, Bas Ponsioen, Maarten Huismans, Sylvia F. Boj, Sander Mertens
Publikováno v:
SSRN Electronic Journal.
Patient-derived organoids (PDO) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify drugs that enhance the efficacy of com
Autor:
Carla S Verissimo, Rachel Elands, Sou Cheng, Dirk-Jan Saaltink, Judith P ter Horst, Maria N Alme, Chantal Pont, Bob van de Water, Bjarte Håvik, Carlos P Fitzsimons, Erno Vreugdenhil
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75752 (2013)
Doublecortin-like (DCL) is a microtubule-binding protein crucial for neuroblastoma (NB) cell proliferation. We have investigated whether the anti-proliferative effect of DCL knockdown is linked to reduced mitochondrial activity. We found a delay in t
Externí odkaz:
https://doaj.org/article/7c3a58d47ee84c3e830b551ad871b99b
Autor:
Hugo J. Snippert, Marc van de Wetering, Johannes L. Bos, Marieke van der Ven, René M. Overmeer, Jarno Drost, David A. Egan, Bastiaan van Gerwen, Hans Clevers, Carla S Verissimo, René Bernards, Sander Mertens, Ingrid Verlaan-Klink, Bas Ponsioen
Publikováno v:
eLife, Vol 5 (2016)
eLife, 5. eLife Sciences Publications
eLife
eLife, 5. eLife Sciences Publications
eLife
Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and